A STUDY ON THE <I>IN VIVO</I> PRODUCTION OF THROMBOSIS IN RAT MESENTERIC ARTERIOLES AND ACTION OF PROSTAGLANDIN (PG) I<SUB>2</SUB> ON THE THROMBOSIS
スポンサーリンク
概要
- 論文の詳細を見る
We have investigated reproducible and quantitative thrombus formation in rat mesenteric arterioles using electrical stimulation under an inverted microscope. <I>In vivo</I> thrombi were formed in arterioles of 30—40 μm diameter by electrical stimulation using a tungsten electrode with a tip of 5 μm diameter. A “threshold” response was defined as one in which platelets adhered to the injured site of vascular wall and formed a white body which flowed away intermittently. The thrombus formations were classified into three stages: stage I, thrombi covering up less than 20% of the vessel lumen; stage II, when 20% to 40% of the lumen was covered; or stage III, when more than 40% was covered. This preparation was demonstrated to be valuable for testing the potency of anti-thrombotic drugs if we performed the experiment within 2 hr after removing the mesentery from the peritoneal cavity which exposed it to air. PGI<SUB>2</SUB>, at a dose of 0.5 μg/100 g intravenously administered, inhibited the growth of the thrombus at stage II and III. PGE<SUB>1</SUB>, PGD<SUB>2</SUB> and PGE<SUB>2</SUB> had no effect at the same dose on these stages. The threshold response was significantly supressed by both PGI<SUB>2</SUB> and PGE<SUB>1</SUB> at doses of 5 μg/100 g.
- 社団法人 日本薬理学会の論文
著者
-
Takano Shizuko
Department of Pharmacology, Fukushima Medical University School of Medicine, Fukushima, 960-1295, Ja
-
SUZUKI Takehiko
Department of Industrial Chemistry, Faculty of Technology, Tokyo Metropolitan University
-
Suzuki Takehiko
Department Of Geography Tokyo Metropolitan University
関連論文
- Serotonin syndrome caused by minimum doses of SSRIS in a patient with spinal cord injury
- New Analytical Chemiluminescence System Using Peroxymonosulfate as Oxidant
- Occurrence Time for Quantum Scattering in the Eikonal Approach
- INHIBITORY EFFECT OF TIARAMIDE ON AGGREGATION IN VIVO AND ON ELECTROPHORESIS OF RABBIT PLATELETS
- INHIBITORY EFFECTS OF PROSTAGLANDIN E1 AND E2 ON CHOLINERGIC TRANSMISSION IN ISOLATED CANINE TRACHEAL MUSCLE
- A COMPARATIVE STUDY ON THE CARDIOTOXICITY OF 5-FLUOROURACIL AND FTORAFUR IN RABBITS
- DEPRESSIVE EFFECT OF EPINEPHRINE MEDIATED VIA ADRENERGIC BETA-RECEPTOR IN ISOLATED RAT COLON AND DUODENUM
- Transfer Angular Distributions in Heavy Ion Collisiions
- A STUDY ON THE IN VIVO PRODUCTION OF THROMBOSIS IN RAT MESENTERIC ARTERIOLES AND ACTION OF PROSTAGLANDIN (PG) I2 ON THE THROMBOSIS
- Modulation Instability of Electron Plasma Wave
- EFFECTS OF PROSTAGLANDINS ON EXCITATORY TRANSMISSION IN ISOLATED CANINE TRACHEAL MUSCLE
- Nonlocal Optical Potential with a Finite Number of Separable Terms
- Time-Dependent Approach to the Interference in Nuclear Scattering
- Effects of Collisions on Temporal Plasma Wave Echose
- Correlation of the Hakkoda-Kokumoto Tephra, a widespread Middle Pleistocene tephra erupted from the Hakkoda Caldera, northeast Japan
- Heavy-Ion Scattering at Energies in the Vicinity of the Barrier Top
- Nonlinear Wave Propagation of Cyclotron Waves in Collisionless Plasmas
- Chemical analysis of volcanic glass by energy dispersive x-ray spectrometry with jeol jed-2001 and jsm-5200 : analytical procedures and application
- A Correction to the Direct Transfer Reaction of Heavy Ion