A COMPARATIVE STUDY ON CONTRACTILE RESPONSES OF RABBIT AND GUINEA PIG VASA DEFERENTIA TO ELECTRICAL FIELD STIMULATION
スポンサーリンク
概要
- 論文の詳細を見る
Contractile responses of rabbit and guinea pig vasa deferentia to electrical field stimulation (EFS) are compared. A muscarinic receptor blocking agent, 1 μM atropine markedly reduced phasic and tonic contraction induced by EFS (20 Hz, 0.5 msec, 30 V, for 30 sec) in rabbit vas deferens, while it only slightly depressed those in guinea pig vas deferens. Further addition of an adrenergic α1 receptor blocking agent, 1 μM prazosin markedly depressed the second tonic contraction in both rabbit and guinea pig vasa deferentia. In the presence of atropine and prazosin, further addition of a P2X purinoceptor desensitizing agent, 10 μM α,β-methylene ATP (α,β-MeATP) abolished the residual phasic contractile response in guinea pig vas deferens, while it partially depressed that in rabbit vas deferens. The administration of 10 μM α,β-MeATP in the absence of atropine and prazosin markedly potentiated the phasic contractile response of rabbit vas deferens to EFS, while it depressed that of guinea pig vas deferens. Contractile response of rabbit vas deferens to α,β-MeATP was more potent than those of ATP and 2-methylthioATP (2-Me-thioATP), while these nucleotides had almost same potency in guinea pig vas deferens. These findings may indicate that contribution of cholinergic, adrenergic and purinergic neurotransmission to the contractile response of rabbit vas deferens to EFS is different from that of guinea pig vas deferens.
- 福島医学会の論文
著者
-
Ono Tomoyuki
Department Of Pharmacology Fukushima Medical College
-
Nakahata Norimichi
Department Of Cellular Signaling And 21st Century Coe Program Graduate School Of Pharmaceutical Scie
-
Nakanishi Hironori
Department Of Pharmacology Fukushima Medical College
-
Ohkubo Satoko
Department Of Cellular Signaling Graduate School Of Pharmaceutical Sciences
-
Matsuoka Isao
Department Of Anesthesiology Ilikai Medical Inc Kakizoe Hospital
-
OHKUBO SATOKO
Department of Cellular Signaling, Graduate School of Pharmaceutical Science, Tohoku University
関連論文
- Mechanism of Statin-Induced Contractile Dysfunction in Rat Cultured Skeletal Myofibers
- The Effect of Pantothenic Acid Deficiency on Keratinocyte Proliferation and the Synthesis of Keratinocyte Growth Factor and Collagen in Fibroblasts
- Involvement of Adenosine A2a Receptor in Intraocular Pressure Decrease Induced by 2-(1-Octyn-1-yl)adenosine or 2-(6-Cyano-1-hexyn-1-yl)adenosine
- Inhibitory Effects of Isoliquiritigenin and Licorice Extract on Voltage-Dependent K^+ Currents in H9c2 Cells
- Antagonism of Saikosaponin-Induced Prostaglandin E_2 Release by Baicalein in C6 Rat Glioma Cells
- Inhibitory Effect of Ethanol Extract of Piper longum L. on Rabbit Platelet Aggregation through Antagonizing Thromboxane A_2 Receptor(Pharmacology)
- Effects of Sho-saiko-to, San'o-shashin-to and Scutellariae Radix on Intracellular Ca^ Mobilization in C6 Rat Glioma Cells
- The Uterus Sustains Stable Biological Clock during Pregnancy
- Inhibitions of Histamine Release and Prostaglandin E_2 Synthesis by Mangosteen, a Thai Medicinal Plant
- Effects of Anions on ATP-Induced[Ca^]_i Increase in NG108-15 Cells
- Inhibitory Effects of Metals on ATP-Induced Current Through P2X_7 Receptor in NG108-15 Cells
- Characteristics of ATP-Induced Current Through P2X_7 Receptor in NG108-15 Cells : Unique Antagonist Sensitivity and Lack of Pore Formation
- THROMBOXANE A_2 RECEPTORS IN RABBIT CULTURED ASTROCYTES
- Inhibitory Effect of Mao-Bushi-Saishin-to on Prostaglandin E_2 Synthesis in C6 Rat Glioma Cells(Pharmacology)
- Ephedrae herba in Mao-Bushi-Saishin-To Inhibits IgE-Mediated Histamine Release and Increases cAMP Content in RBL-2H3 Cells
- Inhibition of Microtubule Polymerization by SK&F 96365, a Blocker of Receptor-Linked Ca^ Entry
- Hepatocyte Growth Factor (HGF) and C-Met/HGF Receptor Expression in Human and Rat Vascular Tissues with Chronic Limb Ischemia
- Lysophosphatidylcholine Increases Na^+/Ca^ Exchanger Expression via RhoB-Geranylgeranylation in H9c2 Cells
- Na^+-Ca^ Exchanger Expression and Its Modulation(Functional Changes Induced by Long-Term Stimulation of Nicotinic Acetylcholine Receptors)
- Inhibitory Effect of Thiopental on Ultra-rapid Delayed Rectifier K^+ Current in H9c2 Cells
- Effects of a Novel Cardioprotective Drug, JTV-519, on Membrane Currents of Guinea Pig Ventricular Myocytes
- Effects of YT : 146 [2 : (1 : Octyny1) Adenosine], an Adenosine A_ Receptor Agonist, on cAMP Production and Noradrenaline Release in PC12 Cells
- Satratoxin H Generates Reactive Oxygen Species and Lipid Peroxides in PC12 Cells(Pharmacology)
- Contribution of Extracellular Signal-Regulated Kinase to UTP-Induced Interleukin-6 Biosynthesis in HaCaT Keratinocytes
- Correlation Between Adenine Nucleotide-Induced Cyclic AMP Elevation and Extracellular Adenosine Formation in NG108-15 Cells
- ATP-and Adenosine-Mediated Signaling in the Central Nervous System : Adenosine Receptor Activation by ATP Through Rapid and Localized Generation of Adenosine by Ecto-nucleotidases
- Alteration of Adenylyl Cyclase Type 6 Expression in Human Astrocytoma Cells After Exposure to Simulated Microgravity
- Physiological Significance of Thromboxane A_2 Receptor Dimerization
- Different Pathways for Activation of Extracellular Signal-Regulated Kinase through Thromboxane A_2 Receptor Isoforms(Pharmacology)
- Selective Up-regulation of P2X_4-Receptor Gene Expression by Interferon-γ in Vascular Endothelial Cells
- Acidic Preconditioning Inhibits Na^+/H^+ and Na^+/Ca^ Exchanger Interaction via PKCε in Guinea-Pig Ventricular Myocytes
- Mechanism of Na^+/Ca^ Exchanger Activation by Hydrogen Peroxide in Guinea-Pig Ventricular Myocytes
- Chronic Administration of Amiodarone Does Not Affect Na^+/Ca^ Exchange Current in Guinea Pig Cardiac Ventricular Myocytes
- Nerve Growth Factor-Inducing Activity of Hericium erinaceus in 1321N1 Human Astrocytoma Cells(Pharmacology)
- PJ-543 Hydrogen Peroxide Activates Na+/Ca2+ Exchanger through Two Different Signaling Pathways in Guinea-Pig Ventricular Myocytes(Myocardial Ischemia-Reperfusion, Basic and Clinical 3 (M) : PJ91)(Poster Session (Japanese))
- ENDOTHELIN-1 INDUCES INOSITOL PHOSPHATE PRODUCTION IN RAT PREGNANT MYOMETRIUM
- Involvement of Adenosine A_ Receptor in Intraocular Pressure Decrease Induced by 2-(1-Octyn-1-yl)adenosine or 2-(6-Cyano-1-hexyn-1-yl)adenosine
- Flexible Tack for Ventral Hernia Repair
- INHIBITORY EFFECTS OF PROSTAGLANDIN E1 AND E2 ON CHOLINERGIC TRANSMISSION IN ISOLATED CANINE TRACHEAL MUSCLE
- A COMPARATIVE STUDY ON THE CARDIOTOXICITY OF 5-FLUOROURACIL AND FTORAFUR IN RABBITS
- DEPRESSIVE EFFECT OF EPINEPHRINE MEDIATED VIA ADRENERGIC BETA-RECEPTOR IN ISOLATED RAT COLON AND DUODENUM
- Inhibitory Effects of Atractylodis Lanceae Rhizoma and Poria on Collagen- or Thromboxane A2-Induced Aggregation in Rabbit Platelets
- Two Distinct Effects of 12S-Hydroxyeicosatetraenoic Acid on Platelet Aggregation by Zooxanthellatoxin-A and Ionomycin
- Maitotoxin-Induced Phosphoinositide Hydrolysis Is Dependent on Extracellular but Not Intracellular Ca^ in Human Astrocytoma Cells
- JUNCTION POTENTIALS IN RESPONSE TO ORTHO- AND ANTI-DROMIC STIMULATION OF HYPOGASTRIC NERVE IN MOUSE VAS DEFERENS
- EFFECTS OF PROSTAGLANDINS ON EXCITATORY TRANSMISSION IN ISOLATED CANINE TRACHEAL MUSCLE
- Inactivation of Membrane Surface Ecto-5'-nucleotidase by Sodium Nitroprusside in C6 Glioma Cells
- Mechanism of Statin-Induced Contractile Dysfunction in Rat Cultured Skeletal Myofibers
- The Effect of Pantothenic Acid Deficiency on Keratinocyte Proliferation and the Synthesis of Keratinocyte Growth Factor and Collagen in Fibroblasts
- Apoptotic effects of satratoxin H is mediated through DNA double-stranded break in PC12 cells
- QUALITATIVELY DIFFERENT RESPONSE OF ISOLATED RABBIT AORTA TO METHYLENE BLUE ADMINISTERED FROM INTIMAL AND ADVENTITIAL SURFACE
- EFFECTS OF FLUVOXAMINE ON BEHAVIORAL AND PSYCHOLOGICAL SYMPTOMS OF DEMENTIA IN ALZHEIMER'S DISEASE : A REPORT OF THREE CASES
- A COMPARATIVE STUDY ON CONTRACTILE RESPONSES OF RABBIT AND GUINEA PIG VASA DEFERENTIA TO ELECTRICAL FIELD STIMULATION
- THE INHIBITORY EFFECT OF SHAKUYAKUKANZOTO ON K+ CURRENT IN H9c2 CELLS
- Contribution of prostaglandin E2 to bradykinin-induced contraction in rabbit urinary detrusor.