Inhibition of Microtubule Polymerization by SK&F 96365, a Blocker of Receptor-Linked Ca^<2+> Entry
スポンサーリンク
概要
- 論文の詳細を見る
SK&F 96365(1-{β-[3-(4-methoxyphenyl)propoxyl]-4-methoxyphenethyl}-1H-imidazole hydrochloride)is widely used as an effective inhibitor of receptor-linked and capacitative Ca2+ entry.Since this inhibitor has additional effects such as inhibition of voltage-dependent Ca2+ channels, sarco- and endoplasmic reticula Ca2+ pumps and cell proliferation, its molecular mechanism of action remains to be solved.In the present study, we have investigated the effect of SK&F 96365 on microtubule protein isolated from bovine brain in vitro.SK&F 96365 depolymerized the polymerized microtubules in a concentration-dependent manner.This result suggests that SK&F 96365 directly depolymerizes microtubules, an effect that may contribute to the various actions of this compound.
- 社団法人 日本薬理学会の論文
- 2000-03-01
著者
-
OHIZUMI Yasushi
Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku U
-
Nakahata Norimichi
Department of Cellular Signaling, Graduate School of Pharmaceutical Sciences, Tohoku University, Jap
-
Ohizumi Yasushi
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni
-
Nakahata N
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni
-
Nakahata Norimichi
Department Of Cellular Signaling And 21st Century Coe Program Graduate School Of Pharmaceutical Scie
-
MITSUI-SAITO Minori
Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku U
-
Mitsui‐saito M
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni
-
Ohizumi Yasushi
Department Of Pharmaceutical Molecular Biology Faculty Of Pharmaceutical Sciences Tohoku University
-
Ohizumi Yasushi
Department Of Anti-dementia Functional Food Development Graduate School Of Engineering Tohoku Univer
-
Ohizumi Yasushi
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni
関連論文
- Shishihakuhito, a traditional Chinese medicine for atopic dermatitis, inhibits IgE-mediated histamine release from rat RBL-2H3 basophilic leukocyte cells
- The Effect of Pantothenic Acid Deficiency on Keratinocyte Proliferation and the Synthesis of Keratinocyte Growth Factor and Collagen in Fibroblasts
- α-Mangostin Induces Ca^-ATPase-Dependent Apoptosis via Mitochondrial Pathway in PC12 Cells
- Involvement of Adenosine A2a Receptor in Intraocular Pressure Decrease Induced by 2-(1-Octyn-1-yl)adenosine or 2-(6-Cyano-1-hexyn-1-yl)adenosine
- Changes in pH Increase Perfusion Pressure of Coronary Arteries in the Rat
- Antisense-Inhibition of Plasma Membrane Ca^ Pump Induces Apoptosis in Vascular Smooth Muscle Cells
- The Mechanism of Rabbit Platelet Aggregation Induced by 2,5-Di-(tert-butyl)-1,4-benzohydroquinone, an Inhibitor of Endoplasmic Reticulum Ca^-ATPase
- The Mode of Inhibitory Action of α-Mangostin, a Novel Inhibitor, on the Sarcoplasmic Reticulum Ca^-Pumping ATPase from Rabbit Skeletal Muscle
- Two New Monoterpene Peroxide Glycosides from Aster scaber
- Antagonism of Saikosaponin-Induced Prostaglandin E_2 Release by Baicalein in C6 Rat Glioma Cells
- Nobiletin, a Citrus Flavonoid That Improves Memory Impairment, Rescues Bulbectomy-Induced Cholinergic Neurodegeneration in Mice
- Inhibitory Effect of Ethanol Extract of Piper longum L. on Rabbit Platelet Aggregation through Antagonizing Thromboxane A_2 Receptor(Pharmacology)
- Effects of Sho-saiko-to, San'o-shashin-to and Scutellariae Radix on Intracellular Ca^ Mobilization in C6 Rat Glioma Cells
- The Uterus Sustains Stable Biological Clock during Pregnancy
- Effects of a Prostaglandin I_2 Analog Iloprost on Cytoplasmic Ca^ Levels and Muscle Contraction in Isolated Guinea Pig Aorta
- Inhibitions of Histamine Release and Prostaglandin E_2 Synthesis by Mangosteen, a Thai Medicinal Plant
- THROMBOXANE A_2 RECEPTORS IN RABBIT CULTURED ASTROCYTES
- Nardosinone Enhances Nerve Growth Factor-Induced Neurite Outgrowth in a Mitogen-Activated Protein Kinase- and Protein Kinase C-Dependent Manner in PC12D Cells
- Nerve Growth Factor-Potentiating Compounds from Picrorhizae Rhizoma
- Enhancement of the Nerve Growth Factor-Mediated Neurite Outgrowth from PC12D Cells by Chinese and Paraguayan Medicinal Plants
- The Powerful Stimulatory Action of 6-O-Acetyl-9-methyl-7-bromoeudistomin D on the Contractile Protein System of Rabbit Skeletal Muscle
- Inhibitory Effect of Mao-Bushi-Saishin-to on Prostaglandin E_2 Synthesis in C6 Rat Glioma Cells(Pharmacology)
- Ephedrae herba in Mao-Bushi-Saishin-To Inhibits IgE-Mediated Histamine Release and Increases cAMP Content in RBL-2H3 Cells
- Inhibition of Microtubule Polymerization by SK&F 96365, a Blocker of Receptor-Linked Ca^ Entry
- Satratoxin H Generates Reactive Oxygen Species and Lipid Peroxides in PC12 Cells(Pharmacology)
- Structure Activity Relationship and Molecular Modeling Analysis of Nantenine Derivatives in 5-HT_ and α_ Receptor Antagonistic Activities
- Constituents of a Paraguayan Medicinal Plant Verbena littoralis H. B. K.
- The Combination of Rat Mast Cell and Rabbit Aortic Smooth Muscle Is the Simple Bioassay for the Screening of Anti-allergic Ingreditent from Methanolic Extract of Corydalis Tuber(Pharmacognosy)
- Contribution of Extracellular Signal-Regulated Kinase to UTP-Induced Interleukin-6 Biosynthesis in HaCaT Keratinocytes
- Alteration of Adenylyl Cyclase Type 6 Expression in Human Astrocytoma Cells After Exposure to Simulated Microgravity
- Physiological Significance of Thromboxane A_2 Receptor Dimerization
- Different Pathways for Activation of Extracellular Signal-Regulated Kinase through Thromboxane A_2 Receptor Isoforms(Pharmacology)
- Ephedrae herba (Mao) decreased histamine content in RBL-2H3 cells
- Clerodane Diterpenoids and Flavonoids with NGF-Potentiating Activity from the Aerial Parts of Baccharis gaudichaudiana
- Nerve Growth Factor-Inducing Activity of Hericium erinaceus in 1321N1 Human Astrocytoma Cells(Pharmacology)
- Iridoids and Sesquiterpenoids with NGF-Potentiating Activity from the Rhizomes and Roots of Valeriana fauriei
- Application of Physiologically Active Substances Isolated from Natural Resources to Pharmacological Studies
- Imaging of Ca^ Release by Caffeine and 9-Methyl-7-bromoeudistomin D and the Associated Activation of Large Conductance Ca^ -Dependent K^+ Channels in Urinary Bladder Smooth Muscle Cells of the Guinea Pig
- Involvement of Adenosine A_ Receptor in Intraocular Pressure Decrease Induced by 2-(1-Octyn-1-yl)adenosine or 2-(6-Cyano-1-hexyn-1-yl)adenosine
- Sesquiterpene Esters from the Fruits of Celastrus orbiculatus
- Stimulation of Sarcoplasmic Reticulum Ca^-ATPase by Gingerol Analogues
- Cicletanine-Induced Decreases in Cytosolic Ca^ Level and Contraction in Vascular Smooth Muscle
- Effects of Chronic Oral Administration of Isosorbide Dinitrate on In Vitro Contractility of Rat Arterial Smooth Muscle
- Honeybee Royal Jelly and Nobiletin Stimulate CRE-Mediated Transcription in ERK-Independent and -Dependent Fashions, Respectively, in PC12D Cells
- Metronomic scheduling of a cyclic hexapeptide Ra-VII for anti-angiogenesis, tumor vessel maturation and anti-tumor activity
- Carbachol but Not Acetylcholine Inhibits Contraction by the Protein Kinase C-Dependent and -Independent Pathways in the Smooth Muscle of Guinea Pig Taenia Caeci
- Proinsulin C-Peptide Stimulates a PKC/IκB/NF-κB Signaling Pathway to Activate COX-2 Gene Transcription in Swiss 3T3 Fibroblasts
- Shishihakuhito, a Kampo Medicine for Atopic Dermatitis, Prevents Lipopolysaccharide-induced Activation of NF-κB-dependent Transcription in C6 Rat Glioma Cells
- Ephedorae herba Decreases Lipopolysaccharide-Induced Cyclooxgenase-2 Protein Expression and NF-κB-Dependent Transcription in C6 Rat Glioma Cells
- A COMPARATIVE STUDY ON THE CARDIOTOXICITY OF 5-FLUOROURACIL AND FTORAFUR IN RABBITS
- DEPRESSIVE EFFECT OF EPINEPHRINE MEDIATED VIA ADRENERGIC BETA-RECEPTOR IN ISOLATED RAT COLON AND DUODENUM
- Search for Herbal Extracts with the Activity to Stimulate Tyrosine Hydroxylase Gene Transcription in PC12D Cells
- V-1 Enhances PMA-Induced Activation of NF-κB-Dependent Transcription in PC12D cells
- Inhibitory Effects of Atractylodis Lanceae Rhizoma and Poria on Collagen- or Thromboxane A2-Induced Aggregation in Rabbit Platelets
- Two Distinct Effects of 12S-Hydroxyeicosatetraenoic Acid on Platelet Aggregation by Zooxanthellatoxin-A and Ionomycin
- Maitotoxin-Induced Phosphoinositide Hydrolysis Is Dependent on Extracellular but Not Intracellular Ca^ in Human Astrocytoma Cells
- EFFECTS OF PROSTAGLANDINS ON EXCITATORY TRANSMISSION IN ISOLATED CANINE TRACHEAL MUSCLE
- Effects of Chinese and Paraguayan Medicinal Plants on the Duration of Immobility of Mice in the Forced Swimming Test
- Excitatory and Inhibitory Effects of Paraguayan Medicinal Plants Equisetum giganteum, Acanthospermum australe, Allophylus edulis and Cordia salicifolia on Contraction of Rabbit Aorta and Guinea-Pig Left Atrium
- Constituents of a Paraguayan Medicinal Plant Verbena littoralis H.B.K.(Natural Medicine Note)
- Inhibitory Action of Paraguayan Medicinal Plants on 5-Lipoxygenase
- Isolation of Acorane-Type Sesquiterpenes from the Paraguayan Medicinal Plant Elinorus latiflorus Nees(Natural Medicine Note)
- Honeybee Royal Jelly and Nobiletin Stimulate CRE-Mediated Transcription in ERK-Independent and -Dependent Fashions, Respectively, in PC12D Cells
- The Effect of Pantothenic Acid Deficiency on Keratinocyte Proliferation and the Synthesis of Keratinocyte Growth Factor and Collagen in Fibroblasts
- Inhibitory Effects of Citrus Polymethoxyflavones, Nobiletin and its Analogues, on Acetylcholinesterase Activity
- 9-Methyl-7-bromoeudistomin D, a Caffeine Like Ca^ Releaser, Probably Binds to Cytochromes P450 1A1 and 2B in Liver Microsomes
- Apoptotic effects of satratoxin H is mediated through DNA double-stranded break in PC12 cells
- The property of active substance from royal jelly in CRE-mediated transcriptional activity
- QUALITATIVELY DIFFERENT RESPONSE OF ISOLATED RABBIT AORTA TO METHYLENE BLUE ADMINISTERED FROM INTIMAL AND ADVENTITIAL SURFACE
- EFFECTS OF FLUVOXAMINE ON BEHAVIORAL AND PSYCHOLOGICAL SYMPTOMS OF DEMENTIA IN ALZHEIMER'S DISEASE : A REPORT OF THREE CASES
- A COMPARATIVE STUDY ON CONTRACTILE RESPONSES OF RABBIT AND GUINEA PIG VASA DEFERENTIA TO ELECTRICAL FIELD STIMULATION
- Contribution of prostaglandin E2 to bradykinin-induced contraction in rabbit urinary detrusor.
- Upregulation of N-methyl-D-aspartate receptor subunits and c-Fos expressing genes in PC12D cells by nobiletin