Nerve Growth Factor-Potentiating Compounds from Picrorhizae Rhizoma
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概要
- 論文の詳細を見る
A crude methanol extract of Picrorhizae Rhizoma, the dried underground parts of Picrorhiza scrophulariiflora PENNELL, has been shown to potentiate the nerve growth factor (NGF)-induced neurite outgrowth from PC12D cells. The methanol extract was partitioned between ethyl acetate and water. The NGF-potentiating activity was observed in the ethyl acetate fraction. The ethxl acetate solubles were fractionated by silica gel chromatography, monitoring the NGF-potentiating activity to give two iridoid glycosides, picrosides I and II. Picrosides did not exhibit neurotrophic activity but caused a marked enhancement of the NGF-mediated neurite outgrowth from PC12D cells. The pharmacological data suggest that picrosides I and II enhance neurite outgrowth from PC12D cells, probably by amplifying a step in the NGF-receptor-mediated intracellular signaling pathway.
- 公益社団法人日本薬学会の論文
- 2000-07-01
著者
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Matsunaga Keiji
Graduate School Of Pharmaceutical Sciences Kyoto University
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OHIZUMI Yasushi
Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku U
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LI Ping
Department of Cell Biology Institute of Nephrology, Niigata University School of Medicine
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Li Ping
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni
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OHIZUMI Yasushi
Graduate School of Pharmaceutical Sciences, Tohoku University
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MATSUNAGA Kimihiro
Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku U
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Yasushi Ohizumi
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni
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Ohizumi Yasushi
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni
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Matsunaga Kazuhisa
Faculty Of Pharmaceutical Sciences Fukuoka University
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Matsunaga K
Faculty Of Pharmaceutical Sciences Fukuoka University
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Matsunaga Kimihiro
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences
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Li Ping
Department Of Cardiology Nagoya University Gradute School Of Medicine
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Li P
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni
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Ohizumi Yasushi
Department Of Pharmaceutical Molecular Biology Faculty Of Pharmaceutical Sciences Tohoku University
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Matsunaga Kimihiro
Department Of Pharmaceutical Molecular Biology Faculty Of Pharmaceutical Sciences Tohoku University
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Mihashi Kunihide
Faculty Of Pharmaceutical Sciences Fukuoka University
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Ohizumi Yasushi
Department Of Anti-dementia Functional Food Development Graduate School Of Engineering Tohoku Univer
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Ohizumi Yasushi
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni
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Matsunaga Kimihiro
Department of Applied Biological Sciences, Faculty of Agriculture, Saga University
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