The Combination of Rat Mast Cell and Rabbit Aortic Smooth Muscle Is the Simple Bioassay for the Screening of Anti-allergic Ingreditent from Methanolic Extract of Corydalis Tuber(Pharmacognosy)

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概要

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• We have assessed the release of histamine from mast cells by smooth muscle contraction. 0.3 μg/ml compound 48/80 showed no effect on concentration-response relationship of histamine in rabbit aorta. Compound 48/80 induced release of histamine from rat mast cells. When aorta was stimulated by compound 48/80 in the presence of mast cells, contraction was evoked in concentration-dependent manner. This mast cell-dependent contraction was completely blocked by H_1, receptor antagonist, 1 μM diphenhydramine. When mast cells was treated with compound 48/80 inhibitor benzalkonium chloride, mast cell-dependent contraction was inhibited, although benzalkonium chloride itself showed no effect on concentration-response relationship of histamine in rabbit aorta. At high concentration of 10 μg/ml, benzalkonium chloride itself evoked histamine release from mast cells and indeed inhibitory effect of 10μg/ml benzalkonium chloride on mast cell-dependent contraction was lower than that of 3 μg/ml. We have applied this bioassay to search anti-allergic ingredient from a total methanolic extract of Corydalis tuber (Corydalis turtschaninovii BESSER forma yanhusuo Y. H. CHOU et C. C. Hsu). Successively, we have isolated five fractions. The fractions I-IV are identified to be corybulbine (1), tetrahydropalmatine (2), corydaline (3) and yuanhunine (4), respectively. Main component of fraction V is the mixture of 3 and canadine (5). Fractions II and V significantly inhibited mast cell-dependent contraction in rabbit aorta as well as inhibited histamine release from rat mast cells. Furthermore, fractions I, III and V inhibited histamine-induced contraction in rabbit aorta at non-competitive manner. From these results, combination of rat mast cells and rabbit aorta is good bioassay to search the anti-allergic ingredient, and we have obtained effective fractions from Corydalis tuber using this assay.

• 公益社団法人日本薬学会の論文
• 2004-08-01

著者

• TANAKA Masashi

  Department of Cardiovascular Surgery, Saitama Medical Center, Jichi Medical University

• OHIZUMI Yasushi

  Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku U

• Tanaka Muneo

  Research Center Shiseido Ltd.

• 田中 誠

  School Of Pharmaceutical Sciences Kitasato University

• Saito Shin-ya

  Department of Pharmaceutical Molecular Biology, Faculty of Pharmaceutical Sciences, Tohoku Universit

• MATSUNAGA Kimihiro

  Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku U

• Ohizumi Yasushi

  Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni

• Saito Shin-ya

  Department Of Pharmaceutical Molecular Biology Faculty Of Pharmaceutical Sciences Tohoku University

• Matsunaga Kimihiro

  Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences

• Li Y

  Research Department Of Natural Medicine Shenyang Pharmaceutical University

• Saito Shin-ya

  Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni

• Tanaka Masashi

  Department Of Cardiovascular Surgery Saitama Medical Center Jichi Medical University

• LI Yushan

  Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku U

• Matsunaga Kimihiro

  Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni

• Ohizumi Yasushi

  Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni

• Ohizumi Yasushi

  Department Of Pharmaceutical Molecular Biology Faculty Of Pharmaceutical Sciences Tohoku University

• Tanaka Masashi

  Department Of Cardiology Hamamatsu Rosai Hospital

• Tanaka Masashi

  Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni

• Matsunaga Kimihiro

  Department Of Pharmaceutical Molecular Biology Faculty Of Pharmaceutical Sciences Tohoku University

• Ohizumi Yasushi

  Department Of Anti-dementia Functional Food Development Graduate School Of Engineering Tohoku Univer

• Saito Shin-ya

  Department Of Pharmaceutical Molecular Bio1ogy Facu1ry Of Pharmaceutical Sciences Tohoku Universiry

• TANAKA Masashi

  Department of Biology, Faculty of Science, Tokyo Metropolitan University

• Matsunaga Kimihiro

  Department of Applied Biological Sciences, Faculty of Agriculture, Saga University

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