Mitochondrial DNA Mutations and Disturbances of Energy Metabolism in Myocardium : 54th Annual Scientific Session of the Japanese Circulation Society
スポンサーリンク
概要
- 論文の詳細を見る
Since mitochondria occupy a pivotal position in energy metabolism, mitochondrial dysfunction is directly linked with disturbances in cellular function. Mitochondria possess their own DNA, which codes 13 subunits of the mitochondrial energy transducing system; the other subunits are coded by nuclear DNA. Recent advances in gene technology, especially the polymerase chain reaction (PCR), permit us to analyze mitochondrial DNA mutations in a small quantity of tissue. We devised rapid and accurate methods to detect mitochondrial DNA mutations, i.e., the primer shift PCR method and the PCR-Southern method. We also developed a method to determine DNA sequences directly without cloning. Using these methods, we revealed that multiple mitochondrial DNA mutations exist in the myocardium of patients with cardiomyopathy. One mutation was based on the following directly repeated sequence: 5'-CATCAACAACCG-3'. This sequence exists in both the ATPase6 gene and the D-loop region, and pseudo-recombination occurs at that directly repeated sequence resulting in a 7.4 kbp deletion. Accordingly, some subunits of the mitochondrial energy transducing system can not be biosynthesized by these deleted mitochondrial DNA, and energy transduction is substantially depleted. Even without reduction of blood supply, mitochondrial DNA mutations can induce a chronic ischemia-like state in the myocardium, which might be a factor in the genesis of cardiomyopathy.
- 社団法人日本循環器学会の論文
- 1991-11-20
著者
-
TANAKA Masashi
Department of Cardiovascular Surgery, Saitama Medical Center, Jichi Medical University
-
SUGIYAMA Satoru
Department of Pharmacology, Aichi Medical University School of Medicine
-
Ozawa Takayuki
Department of Biomedical Chemistry and of Internal Medicine, Faculty of Medicine, University of Nago
-
HATTORI KAZUKI
Departments of Internal Medicine II
-
Ozawa Takayuki
Biomedical Chemistry Faculty Of Medicine University Of Nagoya
-
Sugiyama Satoru
Biomedical Chemistry Faculty Of Medicine University Of Nagoya
-
Sugiyama Satoru
Department Of Biomedical Chemistry
-
TANAKA Masashi
the Department of Biomedical Chemistry, Faculty of Medicine, University of Nagoya
-
Tanaka Masashi
Department Of Cardiovascular Surgery Saitama Medical Center Jichi Medical University
-
Ozawa Takayuki
Departments Of Biomedical Chemistry Faculty Of Medicine University Of Nagoya
-
Ozawa Takayuki
The Department Of Biomedical Chemistry Faculty Of Medicine University Of Nagoya
-
Sugiyama Satoru
Biomedical Chemistyry Faculty Of Medicine University Of Nagoya
-
Sugiyama Satoru
Departments Of Biomedical Chemistry Faculty Of Medicine University Of Nagoya
-
Ozawa T
The Department Of Biomedical Chemistry Faculty Of Medicine University Of Nagoya
-
Sugiyama Satoru
Faculty Of Medicine University Of Nagoya
-
HATTORI KAZUKI
Internal Medicine, Faculty of Medicine, University of Nagoya
-
Ozawa Takayuki
Department Of Biomedical Chemistry
-
Ozawa T
Biomedical Chemistry Faculty Of Medicine University Of Nagoya
-
Tanaka Masashi
The Department Of Biomedical Chemistry Faculty Of Medicine University Of Nagoya
-
Tanaka Masashi
Department Of Cardiology Hamamatsu Rosai Hospital
-
Ozawa Takayuki
Departments Of Biomedical Chemistry University Of Nagoya
-
TANAKA Masashi
Department of Biology, Faculty of Science, Tokyo Metropolitan University
関連論文
- Surgically treated infective endocarditis involving the aortic bicuspid valve and ventricular septum revealing aortic regurgitation and a Gerbode defect
- Endocrine therapy for recurrence after definitive radiotherapy in patients with prostate cancer
- External beam radiation monotherapy for prostate cancer
- Effects of 1-O-hexyl-2,3,5-trimethylhydroquinone on carbon tetrachloride-induced hepatic cirrhosis in rats
- -47- THE MECHANISM OF CARDIAC ARRHYTHMIAS IN DOGS WITH HYPOKALEMIA : Arrhythmias : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 51th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- -59-THE ROLE OF PHOSPHOLIPASE IN THE GENESIS OF REPERFUSION ARRHYTHMIA
- THE EFFECTS OF PHOSPHOLIPASE A_2 ON BETA ADRENOCEPTOR FUNCTION IN ISOLATED CARDIAC CELLS
- A BIOCHEMICAL CONCEPT OF MEMBRANE STABILIZING ACTION OF β-BLOCKING AGENTS : Antianginal Drugs : FREE COMMUNICATIONS (V) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Thermochromism of the Crystals of 2, 3-Bis(phenylthio)-1, 4-naphthoquinone
- Mitochondrial DNA Mutations in Cardiomyopathy : MOLECULAR ANALYSIS OF THE PATHOPHYSIOLOGY OF CARDIOMYPATHY
- Mitochondrial Cytopathy : 53th Annual Scientific Session oh the Japanese Circulation Society
- INFLUENCE OF REGIONAL MYOCARDIAL BLOOD FLOW AND DURATION OF ISCHEMIA ON MYOCARDIAL ORGANIC ACID CONTENTS IN ACUTE ISCHEMIA : Cardiac Metabolism (I) : IV : 48 Annual Scientific Meeting, Japanese Circulation Society
- TIME COURSE OF MYOCARDIAL HIGH ENERGY PHOSPHATES AND ORGANIC ACIDS IN TOTAL ISCHEMIA IN VITRO : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Myocardial Metabolism Biochemistry
- RELATIONSHIP BETWEEN REGIONAL MYOCARDIAL BLOOD FLOW AND HIGH ENERGY PHOSPHATES IN ISCHEMIC MYOCARDIUM : Myocardial metabolism . Biochemistry : 46th Annual Scientific Meeting, Japanese Circulation Society
- RELATIONSHIP BETWEEN REGIONAL MYOCARDIAL BLOOD FLOW AND MITOCHONDRIAL FUNCTION IN EXPERIMENTAL ACUTE ISCHEMIA OF CANINE HEART : Myocardial metabolism Biochemistry : FREE COMMUNICATIONS (Abstract) : 45 Annual Scientific Meeting, Japanese Circulation Societ
- THE EFFECT OF FREE FATTY ACIDS ON ISCHEMIC HEART : IVth Auditorium
- The Effect of Hydrocortisone on Reducing Rates of Restenosis and Target Lesion Revascularization after Coronary Stenting Less than 3 mm in Stent Diameter
- -383- EARLY RECOGNITION OF EXERCISE-INDUCED MYOCARDIAL ISCHEMIA BY PLASMA FREE FATTY ACIDS (FFA)
- -1208-EFFECTS OF γ-BUTYROBETAINE HYDROXYLASE INHIBITOR ON ISOPROTERENOLINDUCED MITOCHONDRIAL DYSFUNCTION : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- -0291-ROLE OF PARASYMPATHETIC NERVOUS SYSTEM IN THE GENESIS OF CARDIOMYOPATHY
- Hepatitis C Virus Infection and Heart Diseases : A Multicenter Study in Japan
- 大腸菌dnaK変異種およびdnaJ変異種におけるRNA合成阻害の解除について〔英文〕
- BODY SURFACE ISOPOTENTIAL MAPS IN DOGS WITH EXPERIMENTAL MYOCARDIAL INFARCTION : Electrocardiography : IInd Auditorium : Proceedings of the 43rd Annual Meeting of the Japanese Circulation Society, Tokyo, 1979
- THE ROLE OF PHOSPHOLIPASE IN THE GENESIS OF MITOCHONDRIAL DYSFUNCTION AFTER CORONARY REPERFUSION : Cardiac Metabolism : FREE COMMUNICATIONS (II) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- MECHANISM AND PROTECTION OF MITOCHONDRIAL DYSFUNCTION IN ISCHEMIC MYOCARDIUM : Cardiac Metabolism : FREE COMMUNICATIONS (II) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- THE EFFECTS OF VERAPAMIL ON HEART MITOCHONDRIAL DYSFUNCTION AFTER CORONARY REPERFUSION : Cardiac Metabolism (I) : IV : 48 Annual Scientific Meeting, Japanese Circulation Society
- THE ROLE OF PHOSPHOLIPASE IN MITOCHONDRIAL DYSFUNCTION AFTER CORONARY REPERFUSION IN THE CANINE MYOCARDIUM
- THE EFFECTS OF β-BLOCKING AGENTS ON MITOCHONDRIAL FUNCTION IN ISCHEMIC MYOCARDIUM
- MECHANISM OF MITOCHONDRIAL DAMAGE AFTER CORONARY REPERFUSION
- MECHANISM OF REPERFUSION ARRHYTHMIAS : PROSTAGLANDIN AS A WASHOUT METABOLITE : Myocardial metabolism . Biochemistry : 46th Annual Scientific Meeting, Japanese Circulation Society
- EXPERIMENTAL STUDY OF MYOCARDIAL INFARCTION THROUGH THE USE OF BODY SURFACE ISOPOTENTIAL MAPS. : LIGATION OF THE ANTERIOR DESCENDING BRANCH OF THE LEFT CORONARY ARTERY : Ist Auditorium : PROCEEDINGS OF THE 40TH ANNUAL MEETING OF THE JAPANESE CIRCULATION S
- THE EFFECT OF VERAPAMIL ON REPERFUSION ARRHYTHMIA IN CANINE HEART
- THE EFFECT OF ENDOTOXIN ON HEART MITOCHONDRIA AND LUNG MICROSOMES IN RATS : Cardiac Metabolism (II) : V : 48 Annual Scientific Meeting, Japanese Circulation Society
- THE EFFECTS OF VERAPAMIL ON MITOCHONDRIAL DYSFUNCTION ASSOCIATED WITH CORONARY REPERFUSION
- ON THE MECHANISM OF ISCHEMIA-INDUCED MITOCHONDRIAL DYSFUNCTION : Myocardial metabolism . Biochemistry : 46th Annual Scientific Meeting, Japanese Circulation Society
- ON THE MECHANISM OF ISCHEMIA-INDUCED MITOCHONDRIAL DYSFUNCTION
- MITOCHONDRIAL DYSFUNCTION AFTER REPERFUSION OF ISCHEMIC MYOCARDIUM IN THE DOG : Myocardial metabolism Biochemistry : FREE COMMUNICATIONS (Abstract) : 45 Annual Scientific Meeting, Japanese Circulation Society
- MECHANISM OF CHLORPROMAZINE-INDUCED ARRHYTHMIA : ARRHYTHMIA AND MITOCHONDRIAL DYSFUNCTION : Cardiovascular drugs (I) : FREE COMMUNICATIONS (Abstract) : 45 Annual Scientific Meeting, Japanese Circulation Society
- Kidney stone disease and risk factors for coronary heart disease
- Significance of capsular atachment and invasion of cancer tissues prostate cancer
- Progression of prostate cancer to neuroendocrine cell tumor
- Change in the ratio of free-to-total prostate-specific antigen during progression of advanced prostate cancer
- Immunohistochemical finding of α-1-antichymotrypsin in tissues of benign prostatic hyperplasia and prostate cancer
- Inhibition of Experimental Metastasis of Human Fibrosarcoma Cells by Anti-recombinant 37-kDa Laminin Binding Protein Antibody
- Mitochondria Encephalomyopathy with A to G Transition of Mitochondrial Transfer RNA ^ 3,243 Presenting Hypertrophic Cardiomyopathy
- Distribution of Geriatric Disease-Related Genotypes in the National Institute for Longevity Sciences, Longitudinal Study of Aging (NILS-LSA)
- 12)RELATIONSHIP AMONG THE ECG, THE VCG AND THE BODY SURFACE ISO-POTENTIAL MAPS IN PATIENTS WITH RIGHT BUNDLE BRANCH BLOCK : THE II CONFERENCE ON VECTORCARDIOGRAPHY
- DIAGNOSIS OF HIGH POSTERIOR INFARCTION THROUGH THE USE OF BODY SURFACE ISOPOTENTIAL MAPS : IVth Auditorium
- Mitochondrial Genotype Associated with the Occurrence of Type 1 Diabetes Mellitus
- A Case of Cardiomyopathy Showing Progression From the Hypertrophic to the Dilated Form : Association of Mt8348A→G Mutation in the Mitochondrial tRNA^ Gene With Severe Ultrastructural Alterations of Mitochondria in Cardiomyocytes
- -0563-DIFFERENCE BETWEEN ARTERIAL AND VENOUS LACTATE LEVELS AS AN INDEX FOR EVALUATION OF MITOCHONDRIAL FUNCTION IN ISCHEMIC MYOCARDIUM
- -0058-MULTIPLE MITOCHONDRIAL DNA DELETIONS IN CARDIOMYOPATHY
- -0041-EFFECTS OF β-AGONISTS IN BOTH MITOCHONDRIAL FUNCTION AND β-ADRENERGIC RECEPTORS
- -281-BIOCHEMICAL AND MORPHOLOGICAL CHANGES IN MYOCARDIUM DURING CORONARY OCCLUSION AND REPERFUSION IN CANINE HEARTS : Ischemic Heart Disease II : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIET
- -535- STUDY OF PLASMA FREE EICOSAPENTAENOIC ACID/ARACHIDONIC ACID RATIO IN IHD PATIENTS
- Electronic Structure of Bi_4Ti_3O_ Thin Film by Soft-X-Ray Emission Spectroscopy
- Association of a G^ → T (Val^ → Phe) polymorphism of the plasma platelet-activating factor acetylhydrolase gene with myocardial damage in Japanese patients with nonfamilial hypertrophic cardiomyopathy
- The Combination of Rat Mast Cell and Rabbit Aortic Smooth Muscle Is the Simple Bioassay for the Screening of Anti-allergic Ingreditent from Methanolic Extract of Corydalis Tuber(Pharmacognosy)
- Successful usage of extracorporeal membrane oxygenation as a bridge therapy for acute pulmonary embolism between hospitals
- -431-MOLECULAR BIOLOGICAL APPROACH OF MITOCHONDRIAL ELECTRON TRANSFER CHAIN : Myocardial Metabolism, Biochemistry : FREE COMMUNICATIONS(II) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- MYOCARDIAL INJURY ASSOCIATED WITH HYPOKALEMIA : Pathophysiology : 53 Annual Scientific Meeting, Japanese Circulation Society
- Association of a polymorphism of the transforming growth factor-β1 gene with blood pressure in Japanese individuals
- Serum Interleukin-6 Levels after Urologic Operations
- CLASSIFICATION OF β-BLOCKING AGENTS BY THEIR INHIBITORY EFFECTS ON PHOSPHOLIPASE ACTIVITY
- MECHANISM RESPONSIBLE FOR "DOWNREGULATION" DURING SUCCESSIVE β-AGONIST ADMINISTRATION IN RAT HEARTS
- MECHANISM OF DECREASE IN THE NUMBER OF β-ADRENERGIC RECEPTOR DURING β-AGONIST ADMINISTRATION : Cardiac Metabolism : FREE COMMUNICATIONS (II) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Risk Factors for Prolonged Mechanical Ventilation Following Surgery for Acute Type A Aortic Dissection
- Cardiac Surgery in Patients Aged 80 Years and Older
- Infected Left Atrial Myxoma With Mitral Valve Endocarditis
- -282-RECOVERY OF MYOCARDIAL MITOCHONDRIAL FUNCTION AFTER CORONARY REPERFUSION : Ischemic Heart Disease II : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Thermochromic Crystals of the CT Complex between N-Salicylidene-2-aminopyridine and 1,3,5-Trinitrobenzene
- Magnetic and Optical Properties of (BEDT-TTF)CuCl_2 Complex : II. LOW TEMPERATURE PROPERTIES OF SOLIDS : Miscellaneous : Phonon, Structure etc.
- The Efficacy of Intravenous Milrinone in Left Ventricular Restoration
- Efficacy of Intraoperative Epiaortic Ultrasound Scanning for Preventing Stroke after Coronary Artery Bypass Surgery
- Extracardiac aneurysm of the interleaflet triangle above the aortic-mitral curtain due to infective endocarditis of the bicuspid aortic valve
- -77- THE HEMODYNAMIC EFFECTS OF LEUKOTOXIN, 9, 10-EPOXY-12-OCTADECENOATE ON CANINE HEARTS : Congestive Heart Failure : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 51th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- -170-A STUDY OF THE ARRHYTHMOGENIC MECHANISM IN HYPOKALEMIA
- Protection of Chlorpromazine-Induced Arrhythmia by Flavin-Adenine-Dinucleotide in Canine Heart
- Growth of Bi_4Ti_3O_ Thin Film by Two-Dimensional RF Magnetron Sputtering with Bi_2O_3 and TiO_2 Targets (Short Note)
- Mitochondrial DNA Mutations and Disturbances of Energy Metabolism in Myocardium : 54th Annual Scientific Session of the Japanese Circulation Society
- Mitochondrial haplogroups associated with lifestyle-related diseases and longevity in the Japanese population
- Redox regulation, gene expression and longevity
- Lymphocyte changes in peripheral blood, spleen, and liver in DMBA-induced squamous cell carcinoma of mouse cheek skin
- Early- and Long-Term Outcomes After Surgery for Acute Type A Aortic Dissection in Patients Aged 45 Years and Younger
- In-hospital and Long-Term Results of Surgery for Acute Type A Aortic Dissection : 243 Consecutive Patients
- Sequential Changes in the Difference Maps of Potential Distributions and the Extent of Myocardial Infarctions
- Beneficial effect of pyruvate therapy on Leigh syndrome due to a novel mutation in PDH E1α gene
- Extensive and rapid screening for major mitochondrial DNA point mutations in patients with hereditary hearing loss
- Antiarrhythmic Effects of L-Penbutolol and DL-Propranolol:Comparison of the Effects of These Two Drugs on Conductivity and Excitability in Canine Heart in Vivo
- Body Surface Isopotential Maps Clinical Application to the Diagnosis of Myocardial Infarction
- Association of mitochondrial DNA polymorphisms and/or haplogroups with elite Japanese athlete status
- Electronic absorption and fluorescence spectra of [2.2]anthracenophanes.
- Gall Bladder B-lymphoblastic Lymphoma Showing Carcinoma-like Appearance
- Optical properties of undoped and AsF5 doped "poly(4,4'-biphenylylene)"films.
- Thermal cis-trans isomerization of (CH)x and (CD)x.
- Heterogeneous photocatalytic decomposition of phenol over TiO2 powder.
- Relationship between regional myocardial blood flow and tissue ATP content in acute ischemia.
- Reflectivity of two-dimensional cluster compound, Nb3I8.
- Electronic spectra and electronic structure of TCNQ complexes.
- The Crystal Structure of (BEDT-TTF)4(Ni(CN)4).