Antiarrhythmic Effects of L-Penbutolol and DL-Propranolol:Comparison of the Effects of These Two Drugs on Conductivity and Excitability in Canine Heart in Vivo

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概要

• 論文の詳細を見る

• The effects of l-penbutolol and dl-propranolol on A-V conduction, on excitability of ventricular muscle, and on ventricular tachycardia threshold in acute ischemia were compared, using anesthetized dogs1. L-penbutolol (100μg/Kg) and dl-propranolol (100μg/Kg) prolonged A-V conduction and reduced excitability of ventricular muscle significantly. L-penbutolol less prolonged A-V conduction than dl-propranolol2. Both l-penbutolol (50μg/Kg) and dl-propranolol (50μg/Kg) significantly prevented the lowering of ventricular tachycardia threshold in acute ischemiaThese beta-blocking drugs are effective in the treatment of arrhythmia and l-penbutolol could be used safely, because of its weaker inhibition on A-V conduction

• International Heart Journal刊行会の論文

著者

• Ohno Miyoshi

  Department Cardiology, Japanese Red Cross Nagoya First Hospital

• NIIMI NOBUO

  Department of Circulation and Respiration , The Research Institute of Environmental Medicine, Nagoya

• Sugenoya Jun-ichi

  Department Of Circulation And Respiration Research Institute Of Environmental Medicine Nagoya Univer

• Sugiyama Satoru

  Department Of Biomedical Chemistry

• Toyama Junji

  Department Of Cardiology Aichi Prefectural Owari Hospital Cardiovascular Center

• Yamada Kazuo

  Department Of Architecture Faculty Of Engineering Aichi Institute Of Technoligy

• TOYAMA Junji

  Department of Circulation and Respiration, Research Institute of Environmental Medicine, Nagoya University

• OHNO Miyoshi

  Department of Circulation and Respiration, Research Institute of Environmental Medicine, Nagoya University

• SUGIYAMA Satoru

  Department of Circulation and Respiration, Research Institute of Environmental Medicine, Nagoya University

• NIIMI Nobuo

  Department of Circulation and Respiration, Research Institute of Environmental Medicine, Nagoya University

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