Effects of Long-term Oral Administration of Amiodarone on the Ventricular Repolarization of Rabbit Hearts
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概要
- 論文の詳細を見る
The chronic effects of amiodarone on ventricular repolarization were investigated in Langendorff-perfused rabbit hearts in comparison with the acute effects of other Class III antiarrhythmic drugs. Forty to fifty electrograms were recorded through modified bipolar electrodes from the anterior to the lateral epicardial surface of the ventricles under His-bundle pacing (1.0 Hz). In control hearts, epicardial activation proceeded from the apex to the base. The interval from the initial sharp negative deflection of the QRS complex to the apex of the T-wave (Q-aT), which reflects the action potential duration (APD) at the recording site, was longest in the apex and shortest in the base. Therefore, repolarization proceeded from the base to the apex. In hearts treated with oral amiodarone (100 mg/kg, 4 weeks), Q-aT was uniformly prolonged by 14-16% throughout the entire mapped area, whereas the activation sequence was unaffected, and a normal Q-aT gradient was well preserved from the apex to the base. The spatial inhomogeneity of left ventricular repolarization was not enhanced by drug treatment. Acute application of sotalol (30 μmol/L), E-4031 (0.1μmol/L) or MS-551 (1.0μmol/L) caused a much greater Q-aT prolongation in the apex than in the base, resulting in a marked enhancement of the spatial inhomogeneity of repolarization. These findings suggest that the propensity of chronic amiodarone to induce torsade de pointes less often than other Class III agents may result at least in part from its favorable effect on the spatial homogeneity of ventricular repolarization.
- 社団法人日本循環器学会の論文
- 1996-08-20
著者
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IWATA Hirokazu
Department 1, R & D Center, Research and Development Group, Ricoh Company, Ltd.
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Kodama Itsuo
Department of Cardiovascular Research, Research Institute of Environmental Medicine, Nagoya Universi
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Kamiya Kaichiro
Department Of Humoral Regulation The Research Institute Of Environmental Medicine Nagoya University
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Toyama J
Aichi Prefecture Hospital
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Toyama Junji
名古屋大学 大学院医学系研究科循環器内科
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Toyama Junji
Department Of Circulation And Respiration The Research Institute Of Environmental Medicine Nagoya Un
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Toyama Junji
Division Of Cardiology Aichi Prefecture Cardiovascular And Respiratory Center
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Suzuki Ryoko
Res.institute Of Environ.med. Nagoya University
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Suzuki Ryoko
Departments Of Surgery Ii Faculty Of Medicine Kochi University
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Suzuki Ryoko
Department Of Biomolecular Science Faculty Of Science Toho University
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Suzuki Ryoko
Department Of Circulation Division Of Regulation Of Organ Function Research Institute Of Environment
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Iwata Hirokazu
Department 1 R & D Center Research And Development Group Ricoh Company Ltd.
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Iwata Hirokazu
Departments Of Circulation And Humoral Regulation Research Institute Of Environmental Medicine Nagoy
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Toyama Junji
Department Of Circulation Division Of Regulation Of Organ Function Research Institute Of Environment
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Kamiya Kaichiro
Department Of Cardiovascular Research Research Institute Of Environmental Medicine Nagoya University
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Kodama Itsuo
Department Of Cardiovascular Research R.i.e.m. Nagoya University
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Toyama Junji
Department Of Cardiology Toyohashi Heart Center
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Toyama Junji
1st Dept. Of Intern. Med. Nagoya Univ.
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Toyama Junji
Department Of Circulation And Respiration The Research Institute Of Environmental Medicine Nagoya Un
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Toyama Junji
Department Of Cardiology Aichi Prefectural Owari Hospital Cardiovascular Center
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Suzuki Ryoko
Department Of Circulation Division Of Regulation Of Organ Function Research Institute Of Environment
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Toyama Junji
Aichi Prefecture Hospital
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Suzuki Ryoko
Department Of Circulation Division Of Regulation Of Organ Function Research Institute Of Environmental Mesicine Nagoya University
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