MECHANISMS OF ATRIAL NATRIURETIC PEPTIDE (ANP) SECRETION BY RAT HEARTS PERFUSED IN VITRO : Ca^<2+>-dependent Signal Transduction for ANP Release by Mechanical Stretch
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概要
- 論文の詳細を見る
Effects of temperature, contracton frequency, and intraatrial pressure on immunoreactive ANP release were investigated in isolated rat hearts perfused in Langendorff or working mode. A reduction of temperature from 37 ℃ to 27 ℃ caused a decrease of ANP release by 64% indicating its marked temperature-dependency (Q_<10>=2.92). An increase of atrial contraction frequncy from 300 to _500/min in Langendorff-perfused hearts did not cause a significant change in the ANP release. An elevation of left atrial filling pressure of working hearts from 8 to 18 and 28 cm H_2O was associated with pressure-dependent, and reversible increase of the ANP release. This pressure-induced release of ANP was inhibited in a low calcium (50% Ca^<2+>) medium or by nifedipine (10^<-7>M). N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide (W-7, 10^<-7>M), a potent calmodulin inhibitor, or ryanodine (10^<-8>M) had similar inhibitory action against the pressure-induced increase of ANP release. These results indicate that ANP sectetion is primarily regulated by mechanical stretch or distension of the atrial wall, while the atrial contraction frequency is less important as a physiological stimulus for the secretion. The stretch-induced ANP secretion may reqiure an influx of calcium through the voltage-dependent Ca^<2+> channels. It was also suggested that Ca^<2+> release from the sarcoplasmic reticulum leading to an activation of calcium-calmodulin kinase may be included in the intracellular processes of ANP release by mechanical stretch.
- 社団法人日本循環器学会の論文
- 1990-10-20
著者
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Kodama Itsuo
Department of Cardiovascular Research, Research Institute of Environmental Medicine, Nagoya Universi
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Toyama J
Aichi Prefecture Hospital
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Toyama Junji
名古屋大学 大学院医学系研究科循環器内科
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Toyama Junji
Department Of Circulation And Respiration The Research Institute Of Environmental Medicine Nagoya Un
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Yamashita Kentaro
Cardiovascular Center Nagoya Daini Red Cross Hospital
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Seo Hisao
Department of Endocrinology and Metabolism, Research Institute of Environmental Medicine, Nagoya Uni
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KATOH SHUHEI
Department of Circulation and Respiration, The Research Institute of Environmental Medicine, Nagoya
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AOYAMA MICHIHIKO
Department of Circulation and Respiration, The Research Institute of Environmental Medicine, Nagoya
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MIYAMOTO NORIHIRO
Department of Endocrinology and Metabolism, The Research Institute of Environmental Medicine, Nagoya
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MATSUI NOBUO
Department of Endocrinology and Metabolism, The Research Institute of Environmental Medicine, Nagoya
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YAMADA KAZUO
Meitetsu Hospital
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Seo Hisao
名古屋大学環境医学研究所
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Seo H
Nagoya Univ. Nagoya Jpn
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Miyamoto Norihiro
Department Of Endocrinology And Metabolism The Research Institute Of Environmental Medicine Nagoya U
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Aoyama Michihiko
Department Of Circulation And Respiration The Research Institute Of Environmental Medicine Nagoya Un
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Seo Hisao
Department Of Endocrinology And Metabolism Division Of Molecular And Cellular Adaptation Research In
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Seo Hisao
Research Institute Of Environmental Medicine Nagoya University
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Seo Hisao
Department Of Endocrinology And Metabolism The Research Institute Of Environmental Medicine Nagoya U
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Matsui N
Department Of Obstetrics And Gynecology And Research Institute Of Environmental Medicine Nagoya Univ
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Toyama Junji
Department Of Circulation Division Of Regulation Of Organ Function Research Institute Of Environment
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Yamada Kazuo
Division Of Circulation And Respiration The Research Institute Of Environmental Medicine Nagoya Univ
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Matsui Nobuo
Department Of Endocrinology And Metabolism The Research Institute Of Environmental Medicine Nagoya U
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Kodama Itsuo
Department Of Cardiovascular Research R.i.e.m. Nagoya University
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Matsul Nobuo
The Research Institute Of Environmental Medicine Nagoya University
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Katoh Shuhei
Department Of Circulation And Respiration The Research Institute Of Environmental Medicine Nagoya Un
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Toyama Junji
Department Of Cardiology Toyohashi Heart Center
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Toyama Junji
Department Of Cardiology Aichi Prefectural Owari Hospital Cardiovascular Center
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Matsui Nobuo
Department Of Endocrinology And Metabolism The Research Institute Of Environmental Medicine Nagoya U
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SEO Hisao
Department of Biomedical Science, College of Life and Health Sciences, Chubu University
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