Hepatitis C Virus Infection and Heart Diseases : A Multicenter Study in Japan

概要

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As a collaborative research project of the Committees for the Study of Idiopathic Cardiomypathy, a questionnaire was sent out to 19 medical institutions in Japan in order to examine the possible association between hepatitis C virus(HCV)infection and cardiomyopathies.Hepatitis C virus antibody was found in 74 of 697 patients(10.6%)with hypertrophic cardiomyopathy(mean age, 57.7 years)and in 42 of 663 patients(6.3%)with dilated cardiomyopathy(mean age, 56.5 years);these prevalences were significantly higher than that found in volunteer blood donors in Japan(2.4%, 50-59 years of age, each p<0.0001).The prevalence was significantly higher in patients suffering from hypertrophic cardiomyopathy as opposed to those with dilated cardiomyopathy(p<0.01).The presence of HCV antibody was detected in 650 of 11, 967 patients(5.4%)patients seeking care in 5 academic hospitals.Various cardiac abnormalities were found among these patients, arrhythmias being the most frequent.These observations suggest that HCV infection is an important cause of a variety of otherwise unexplained heart diseases.
社団法人日本循環器学会の論文
1998-04-20