Association of mitochondrial DNA polymorphisms and/or haplogroups with elite Japanese athlete status

スポンサーリンク

概要

• 論文の詳細を見る

• A number of familial and twin studies have assessed the relative contribution of genetic and environmental factors to physical performance or its-related traits and have estimated that there is a significant genetic component to their phenotypes. In addition, aerobic capacity has been found to have stronger maternal inheritance than paternal. This finding implies that functional differences in maternally inherited mtDNA-encoded proteins involved in oxidative phosphorylation affect aerobic performance. In this article, therefore, we focus on associations between mtDNA polymorphisms/haplogroups and elite Japanese athlete status. From sequencing analysis of the control region in the mtDNA, certain mtDNA polymorphisms and haplogroups were shown to be associated with elite Japanese endurance athlete status, probably due to enhanced ATP production by mitochondria in the cardiac and skeletal muscles or both. This phenomenon is in agreement with several previous reports on Caucasian and African populations. It should be noted that certain mtDNA polymorphisms or haplogroups are also associated with elite Japanese sprint athlete/power status, probably due to enhanced calcium dynamics in the skeletal muscle. Thus, mtDNA polymorphisms/haplogroups influence not only aerobic performance but also anaerobic performance.

著者

• Fuku Noriyuki

  Department Of Genomics For Longevity And Health Tokyo Metropolitan Institute Of Gerontology

• TANAKA Masashi

  Department of Biology, Faculty of Science, Tokyo Metropolitan University

• Mikami Eri

  Department of Genomics for Longevity and Health, Tokyo Metropolitan Institute of Gerontology

関連論文

• Surgically treated infective endocarditis involving the aortic bicuspid valve and ventricular septum revealing aortic regurgitation and a Gerbode defect
• Endocrine therapy for recurrence after definitive radiotherapy in patients with prostate cancer
• External beam radiation monotherapy for prostate cancer
• Thermochromism of the Crystals of 2, 3-Bis(phenylthio)-1, 4-naphthoquinone
• Mitochondrial Cytopathy : 53th Annual Scientific Session oh the Japanese Circulation Society
• 大腸菌dnaK変異種およびdnaJ変異種におけるRNA合成阻害の解除について〔英文〕
• Kidney stone disease and risk factors for coronary heart disease
• Significance of capsular atachment and invasion of cancer tissues prostate cancer
• Progression of prostate cancer to neuroendocrine cell tumor
• Change in the ratio of free-to-total prostate-specific antigen during progression of advanced prostate cancer
• Immunohistochemical finding of α-1-antichymotrypsin in tissues of benign prostatic hyperplasia and prostate cancer
• Inhibition of Experimental Metastasis of Human Fibrosarcoma Cells by Anti-recombinant 37-kDa Laminin Binding Protein Antibody
• Effect of Voluntary Wheel-Running on Insulin Sensitivity and Responsiveness in High-Fat-Fed Rats
• Distribution of Geriatric Disease-Related Genotypes in the National Institute for Longevity Sciences, Longitudinal Study of Aging (NILS-LSA)
• Mitochondrial Genotype Associated with the Occurrence of Type 1 Diabetes Mellitus
• A Case of Cardiomyopathy Showing Progression From the Hypertrophic to the Dilated Form : Association of Mt8348A→G Mutation in the Mitochondrial tRNA^ Gene With Severe Ultrastructural Alterations of Mitochondria in Cardiomyocytes
• -0058-MULTIPLE MITOCHONDRIAL DNA DELETIONS IN CARDIOMYOPATHY
• Electronic Structure of Bi_4Ti_3O_ Thin Film by Soft-X-Ray Emission Spectroscopy
• Association of a G^ → T (Val^ → Phe) polymorphism of the plasma platelet-activating factor acetylhydrolase gene with myocardial damage in Japanese patients with nonfamilial hypertrophic cardiomyopathy
• The Combination of Rat Mast Cell and Rabbit Aortic Smooth Muscle Is the Simple Bioassay for the Screening of Anti-allergic Ingreditent from Methanolic Extract of Corydalis Tuber(Pharmacognosy)
• Successful usage of extracorporeal membrane oxygenation as a bridge therapy for acute pulmonary embolism between hospitals
• Association of a polymorphism of the transforming growth factor-β1 gene with blood pressure in Japanese individuals
• Serum Interleukin-6 Levels after Urologic Operations
• Risk Factors for Prolonged Mechanical Ventilation Following Surgery for Acute Type A Aortic Dissection
• Cardiac Surgery in Patients Aged 80 Years and Older
• Thermochromic Crystals of the CT Complex between N-Salicylidene-2-aminopyridine and 1,3,5-Trinitrobenzene
• Magnetic and Optical Properties of (BEDT-TTF)CuCl_2 Complex : II. LOW TEMPERATURE PROPERTIES OF SOLIDS : Miscellaneous : Phonon, Structure etc.
• The Efficacy of Intravenous Milrinone in Left Ventricular Restoration
• Efficacy of Intraoperative Epiaortic Ultrasound Scanning for Preventing Stroke after Coronary Artery Bypass Surgery
• Extracardiac aneurysm of the interleaflet triangle above the aortic-mitral curtain due to infective endocarditis of the bicuspid aortic valve
• Growth of Bi_4Ti_3O_ Thin Film by Two-Dimensional RF Magnetron Sputtering with Bi_2O_3 and TiO_2 Targets (Short Note)
• Mitochondrial DNA Mutations and Disturbances of Energy Metabolism in Myocardium : 54th Annual Scientific Session of the Japanese Circulation Society
• Mitochondrial haplogroups associated with lifestyle-related diseases and longevity in the Japanese population
• Redox regulation, gene expression and longevity
• Lymphocyte changes in peripheral blood, spleen, and liver in DMBA-induced squamous cell carcinoma of mouse cheek skin
• Early- and Long-Term Outcomes After Surgery for Acute Type A Aortic Dissection in Patients Aged 45 Years and Younger
• In-hospital and Long-Term Results of Surgery for Acute Type A Aortic Dissection : 243 Consecutive Patients
• Comparative Study of the Analytical Values and Food Composition Table Values of Proteins and the Proportions of their Amino Acid Components in Foods
• S-I-4 Mitochondrial DNA polymorphisms and haplogroups associated with physical performance(The Proceedings of the 19th Annual Meetings of Japan Society of Exercise and Sports Physiology August 25・26, (Tokushima))
• Beneficial effect of pyruvate therapy on Leigh syndrome due to a novel mutation in PDH E1α gene
• Extensive and rapid screening for major mitochondrial DNA point mutations in patients with hereditary hearing loss
• Association of mitochondrial DNA polymorphisms and/or haplogroups with elite Japanese athlete status
• Electronic absorption and fluorescence spectra of [2.2]anthracenophanes.
• Optical properties of undoped and AsF5 doped "poly(4,4'-biphenylylene)"films.
• Thermal cis-trans isomerization of (CH)x and (CD)x.
• Heterogeneous photocatalytic decomposition of phenol over TiO2 powder.
• Reflectivity of two-dimensional cluster compound, Nb3I8.
• Electronic spectra and electronic structure of TCNQ complexes.
• The Crystal Structure of (BEDT-TTF)4(Ni(CN)4).
• Electrical and optical properties of a stable synthetic metallic polymer: polypyrrole.
• Absorption spectra of the polyacetylene films doped with BF3.
• Optical and magnetic properties of (DBTTF)2(Cu2Cl6) and (DBTTF)2(Cu2Br6) complexes.
• Infrared and visible absorption spectra of doped (CH)x,(CD)x, and copolymers ((C2H2)1-y(C2D2)y)x.
• Association of 29C>T polymorphism in the transforming growth factor-β1 gene with lean body mass in community- dwelling Japanese population
• Electronic structure of (BEDT-TTF)CuCl2 complex.
• Electronic spectra of (DBTTF)3SnBr6 complex.
• Extended screening for major mitochondrial DNA point mutations in patients with hereditary hearing loss
• Association of the formiminotransferase N-terminal sub-domain containing gene and thrombospondin, type 1, domain-containing 7A gene with the prevalence of vertebral fracture in 2427 consecutive autopsy cases

もっと見る 閉じる

スポンサーリンク