Ephedrae herba in Mao-Bushi-Saishin-To Inhibits IgE-Mediated Histamine Release and Increases cAMP Content in RBL-2H3 Cells

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概要

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• Acute effect of Mao-Bushi-Saishin-To (Ma-Huang-Fu-Zi-Xi-Xin-Tang in Chinese: MBS) on histamine release was investigated. The IgE-mediated anaphylaxic response in Wistar rats was significantly suppressed by MBS and Mao. However, Saishin and Bushi had no or little effect on the antigen-mediated anaphylaxic reaction. Mao as well as MBS but not Saishin nor Bushi inhibited IgE-mediated histamine release from rat basophilic leukemia (RBL-2H3) cells. Consistently, MBS and Mao but not Bushi nor Saishin increased cAMP levels in RBL-2H3 cells. However, ephedrine, methylephedrine, and pseudoephedrine, the main components in Mao, did not affect histamine release. From these results, increase of cAMP levels may account for the inhibitory effect of Mao on histamine release. Furthermore, these inhibitory actions of MBS were mainly due to Mao with an ingredient(s) different from ephedrines.

• 社団法人 日本薬理学会の論文
• 2004-05-20

著者

• OHIZUMI Yasushi

  Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku U

• Nakahata Norimichi

  Department of Cellular Signaling, Graduate School of Pharmaceutical Sciences, Tohoku University, Jap

• Maruyama Yukiko

  Department of Essential Drugs and Medicines Policy, World Health Organization

• OHIZUMI Yasushi

  Graduate School of Pharmaceutical Sciences, Tohoku University

• Saito Shin-ya

  Department of Pharmaceutical Molecular Biology, Faculty of Pharmaceutical Sciences, Tohoku Universit

• Oshima Yasukatsu

  Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni

• Yasushi Ohizumi

  Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni

• Ohizumi Yasushi

  Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni

• Saito Shin-ya

  Department Of Pharmaceutical Molecular Biology Faculty Of Pharmaceutical Sciences Tohoku University

• Saito S

  Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni

• Nakahata N

  Department Of Cellular Signaling Graduate School Of Pharmaceutical Sciences Tohoku University

• Nakahata Norimichi

  Department Of Cellular Signaling And 21st Century Coe Program Graduate School Of Pharmaceutical Scie

• Nakahata Norimichi

  Inst. For International Advanced Res. And Education Tohoku Univ. International Advanced Res. And Edu

• KAMIYAMA Sachie

  Department of Pharmaceutical Molecular Biology, Tohoku University

• Kamiyama Sachie

  Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni

• Maruyama Yukiko

  Department Of Pharmaceutical Molecular Biology Tohoku University

• Ohizumi Yasushi

  Department Of Pharmaceutical Molecular Biology Faculty Of Pharmaceutical Sciences Tohoku University

• Ohizumi Yasushi

  Department Of Anti-dementia Functional Food Development Graduate School Of Engineering Tohoku Univer

• Ohizumi Yasushi

  Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni

• Saito Shin-ya

  Department Of Pharmaceutical Molecular Bio1ogy Facu1ry Of Pharmaceutical Sciences Tohoku Universiry

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