Inhibitory Effects of Atractylodis Lanceae Rhizoma and Poria on Collagen- or Thromboxane A2-Induced Aggregation in Rabbit Platelets
スポンサーリンク
概要
- 論文の詳細を見る
Kami-shoyo-san (Jia-Wei-Xiao-Yao-San), Toki-shakuyaku-san (Dang-Gui-Shao-Yao-San) and Toki-shigyaku-ka-goshuyu-shokyo-to (Dang-Gui-Si-Ni-Jia-Wu-Zhu-Yu-Sheng-Jiang-Tang) are Kampo (traditional Chinese) medicines which are traditionally and effectively used for the treatment of chilly sensation (Hiesho) in Japan, but the active components and their detailed mechanisms have not yet been clarified. Etiologies of Hiesho include poor peripheral blood circulation and platelet aggregability contributes to peripheral blood circulation; therefore, we investigated the effect of Kampo medicines on platelet aggregation using rabbit platelets in vitro. Collagen and U46619, a thromboxane A2 receptor agonist, caused rabbit platelet aggregation, which was potently inhibited by pretreatment of platelets with Kami-shoyo-san and Toki-shakuyaku-san in vitro. Toki-shigyaku-ka-goshuyu-shokyo-to, however, did not significantly inhibit collagen- or U46619-induced platelet aggregation. Therefore, we examined the effect on platelet aggregation of two herbal medicines, Atractylodis Lanceae Rhizoma and Poria, both of which are contained in Kami-shoyo-san and Toki-shakuyaku-san but not in Toki-shigyaku-ka-goshuyu-shokyo-to. As the results indicate, Atractylodis Lanceae Rhizoma inhibited platelet aggregation induced by collagen but not by U46619. Poria effectively inhibited U46619-induced platelet aggregation and it partially inhibited collagen-induced platelet aggregation. On the other hand, Atractylodis Lanceae Rhizoma and Poria did not inhibit adrenaline/adenosine diphosphate- or adrenaline/serotonin-induced platelet aggregation. These results suggest the possibility that the inhibition of platelet aggregation by two Kampo medicines, Kami-shoyo-san and Toki-shakuyaku-san, is one of the mechanisms underlying the improvement of Hiesho. Furthermore, Atractylodis Lanceae Rhizoma and Poria are possible herbal medicines for the inhibition of platelet aggregation.
- 公益社団法人 日本薬学会の論文
著者
-
FUSHIYA Shinji
Nihon Pharmaceutical University
-
SAITO Masaki
Department of Biochemistry, Hyogo College of Medicine
-
Nakahata Norimichi
Department Of Cellular Signaling And 21st Century Coe Program Graduate School Of Pharmaceutical Scie
-
IWASHITA Masaya
Department of Cellular Signaling, Graduate School of Pharmaceutical Sciences, Tohoku University
-
Nasu Yuiko
Department of Cellular Signaling, Graduate School of Pharmaceutical Sciences, Tohoku University
-
Saito Masaki
Department Of Biochemistry Hyogo College Of Medicine
-
Saito Masaki
Department of Cellular Signaling, Graduate School of Pharmaceutical Sciences, Tohoku University
関連論文
- The Effect of Pantothenic Acid Deficiency on Keratinocyte Proliferation and the Synthesis of Keratinocyte Growth Factor and Collagen in Fibroblasts
- Distinction of water-soluble constituents between some Paecilomyces (= Isaria) and Cordyceps fungi by capillary electrophoresis
- Involvement of Adenosine A2a Receptor in Intraocular Pressure Decrease Induced by 2-(1-Octyn-1-yl)adenosine or 2-(6-Cyano-1-hexyn-1-yl)adenosine
- Antagonism of Saikosaponin-Induced Prostaglandin E_2 Release by Baicalein in C6 Rat Glioma Cells
- Three Conserved Glycine Residues in Valine Activation of Gramicidin S Synthetase 2 from Bacillus brevis^1
- Inhibitory Effect of Ethanol Extract of Piper longum L. on Rabbit Platelet Aggregation through Antagonizing Thromboxane A_2 Receptor(Pharmacology)
- Effects of Sho-saiko-to, San'o-shashin-to and Scutellariae Radix on Intracellular Ca^ Mobilization in C6 Rat Glioma Cells
- The Uterus Sustains Stable Biological Clock during Pregnancy
- Inhibitions of Histamine Release and Prostaglandin E_2 Synthesis by Mangosteen, a Thai Medicinal Plant
- THROMBOXANE A_2 RECEPTORS IN RABBIT CULTURED ASTROCYTES
- Inhibitory Effect of Mao-Bushi-Saishin-to on Prostaglandin E_2 Synthesis in C6 Rat Glioma Cells(Pharmacology)
- Ephedrae herba in Mao-Bushi-Saishin-To Inhibits IgE-Mediated Histamine Release and Increases cAMP Content in RBL-2H3 Cells
- Inhibition of Microtubule Polymerization by SK&F 96365, a Blocker of Receptor-Linked Ca^ Entry
- Satratoxin H Generates Reactive Oxygen Species and Lipid Peroxides in PC12 Cells(Pharmacology)
- Contribution of Extracellular Signal-Regulated Kinase to UTP-Induced Interleukin-6 Biosynthesis in HaCaT Keratinocytes
- Alteration of Adenylyl Cyclase Type 6 Expression in Human Astrocytoma Cells After Exposure to Simulated Microgravity
- Physiological Significance of Thromboxane A_2 Receptor Dimerization
- Different Pathways for Activation of Extracellular Signal-Regulated Kinase through Thromboxane A_2 Receptor Isoforms(Pharmacology)
- Intact Cell Binding for In Vitro Prediction of Sedative and Non-sedative Histamine H_1-Receptor Antagonists Based on Receptor Internalization
- Nerve Growth Factor-Inducing Activity of Hericium erinaceus in 1321N1 Human Astrocytoma Cells(Pharmacology)
- Involvement of Adenosine A_ Receptor in Intraocular Pressure Decrease Induced by 2-(1-Octyn-1-yl)adenosine or 2-(6-Cyano-1-hexyn-1-yl)adenosine
- A Female Carrier of Duchenne Muscular Dystrophy Complicated with Cardiomyopathy
- Hybrid Inorganic-Organic Crystals Composed of Octamolybdate Isomers and Pyridinium Surfactant
- Correlation between the M and F wave characteristics and the innervated muscle strength in spinal muscular atrophy
- Augmentation of α_1-Adrenoceptor-Mediated Contraction by Warming Without Increased Phosphorylation of Myosin in Rat Caudal Arterial Smooth Muscle
- A COMPARATIVE STUDY ON THE CARDIOTOXICITY OF 5-FLUOROURACIL AND FTORAFUR IN RABBITS
- DEPRESSIVE EFFECT OF EPINEPHRINE MEDIATED VIA ADRENERGIC BETA-RECEPTOR IN ISOLATED RAT COLON AND DUODENUM
- Inhibitory Effects of Atractylodis Lanceae Rhizoma and Poria on Collagen- or Thromboxane A2-Induced Aggregation in Rabbit Platelets
- A NEW PROCEDURE FOR YIELDING A RAPID SOLUTION BY USE OF THE MULTI-θ METHOD OF CONVERGENCE
- Two Distinct Effects of 12S-Hydroxyeicosatetraenoic Acid on Platelet Aggregation by Zooxanthellatoxin-A and Ionomycin
- Maitotoxin-Induced Phosphoinositide Hydrolysis Is Dependent on Extracellular but Not Intracellular Ca^ in Human Astrocytoma Cells
- EFFECTS OF PROSTAGLANDINS ON EXCITATORY TRANSMISSION IN ISOLATED CANINE TRACHEAL MUSCLE
- The Effect of Pantothenic Acid Deficiency on Keratinocyte Proliferation and the Synthesis of Keratinocyte Growth Factor and Collagen in Fibroblasts
- Apoptotic effects of satratoxin H is mediated through DNA double-stranded break in PC12 cells
- QUALITATIVELY DIFFERENT RESPONSE OF ISOLATED RABBIT AORTA TO METHYLENE BLUE ADMINISTERED FROM INTIMAL AND ADVENTITIAL SURFACE
- Formation of N,N'-disubstituted methanediamine derivatives from hexamethyldisilazane and aldehydes via stepwise reactions.
- EFFECTS OF FLUVOXAMINE ON BEHAVIORAL AND PSYCHOLOGICAL SYMPTOMS OF DEMENTIA IN ALZHEIMER'S DISEASE : A REPORT OF THREE CASES
- Influence of Void and Velocity Variations on Two-Phase Liquid Metal MHD Induction Converter Characteristics
- A COMPARATIVE STUDY ON CONTRACTILE RESPONSES OF RABBIT AND GUINEA PIG VASA DEFERENTIA TO ELECTRICAL FIELD STIMULATION
- Contribution of prostaglandin E2 to bradykinin-induced contraction in rabbit urinary detrusor.
- Analysis of Two-Phase Liquid Metal MHD Induction Converter
- Redistribution of gaseous phase of liquid metal two-phase flow in a strong magnetic field.
- Entecavir and interferon-α sequential therapy in Japanese patients with hepatitis B e antigen-positive chronic hepatitis B