Satratoxin H Generates Reactive Oxygen Species and Lipid Peroxides in PC12 Cells(Pharmacology)
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概要
- 論文の詳細を見る
Satratoxin H, a mycotoxin, is thought to induce apoptosis of PC12 cells through the activation of p38 mitogen-activated protein kinase (MAPK) and c-Jun N-terminal kinase (JNK) in a glutathione (GSH)-sensitive manner. The present study was undertaken to further elucidate the mechanism by which satratoxin H induces cell death in PC12 cells. Satratoxin H caused apoptosis of PC12 cells within 24-h, as determined by DNA fragmentation and flow cytometric analysis. Satratoxin H increased reactive oxygen species (ROS) production and lipid peroxidation, as determined by malondialdehyde formation. These effects were attenuated by incubation of cells with GSH, suggesting that satratoxin H-induced increase in apoptosis of serum-deprived PC12 cells may be partially mediated through the generation of ROS.
- 公益社団法人日本薬学会の論文
- 2008-06-01
著者
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Yoshida Makoto
Department of Internal Medicine, Kitasato University School of Medicine
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MIZUGAKI Michinao
Department of Clinical Pharmaceutics, Tohoku Pharmaceutical University
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Nakahata Norimichi
Department of Cellular Signaling, Graduate School of Pharmaceutical Sciences, Tohoku University, Jap
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Meksuriyen Duangdeun
Department of Biochemistry, Chulalongkorn University
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Mizugaki Michinao
Department Of Clinical Pharmaceutics Tohoku Pharmaceutical University
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Mizugaki Michinao
Department Of Clinical Pharmacy Tohoku Pharmaceutical University
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Nakahata Norimichi
Department Of Cellular Signaling And 21st Century Coe Program Graduate School Of Pharmaceutical Scie
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Nakahata Norimichi
Department Of Cellular Signaling Graduate School Of Pharmaceutical Sciences Tohoku University:21st C
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NUSUETRONG Punnee
Department of Physiology, Faculty of Medicine, Srinakharinwirot University
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PENGSUPARP Thitima
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University
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TANITSU Masaaki
Department of Natural Products Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku Univers
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KIKUCHI Haruhisa
Department of Natural Products Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku Univers
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SHIMAZU Ken-ichi
Department of Pharmacy, Takahata Hospital
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OSHIMA Yoshiteru
Department of Natural Products Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku Univers
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Pengsuparp Thitima
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Chulalongkorn University
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Shimazu Ken-ichi
Department Of Pharmacy Takahata Hospital
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Meksuriyen Duangdeun
Department Of Biochemistry Chulalongkorn University
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Meksuriyen Duangdeun
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Chulalongkorn University
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Oshima Yoshiteru
Department Of Natural Products Chemistry Graduate School Of Pharmaceutical Sciences Tohoku Universit
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Tanitsu Masaaki
Department Of Natural Products Chemistry Graduate School Of Pharmaceutical Sciences Tohoku Universit
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Kikuchi Haruhisa
Department Of Natural Products Chemistry Graduate School Of Pharmaceutical Sciences Tohoku Universit
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Nusuetrong Punnee
Department Of Physiology Faculty Of Medicine Srinakharinwirot University:department Of Biochemistry
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Yoshida Makoto
Department Of Pharmacology Faculty Of Pharmacy Takasaki University Of Health And Welfare
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Yoshida Makoto
Department Of Biology Faculty Of Science University Of Kochi
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Nusuetrong Punnee
Department Of Cellular Signaling Graduate School Of Pharmaceutical Sciences Tohoku University
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