Phenobarbital Molecularly Imprinted Polymer Selectively Binds Phenobarbital
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概要
- 論文の詳細を見る
Molecularly imprinted polymer (MIP) was propared against phenobarbital using methacrylic acid as the functional monomer and ethylene glycol dimethacrylate as the cross linking monomer. We analyzed the recognition properties of the phenobarbital MIP. In some organic solvents, imprinted polymer showed selective binding to phenobarbital. Two dissociation constants of binding were calculated by Scatchard plot analyses; K_d values were 1.8,121.7 μM, and the number of binding sites was 8.3,92.3 μmol/g MIP in toluene-heptane-acetic acid (25 : 75 : 1,v/v), respectively. The relationship between the binding affinity to phenobarbital MIP and the polarity of the solvent system, as well as the structure of the template molecule is also discussed.
- 社団法人日本薬学会の論文
- 1997-04-15
著者
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MIZUGAKI Michinao
Department of Clinical Pharmaceutics, Tohoku Pharmaceutical University
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Nakamura Hitoshi
Department of Cardiology, Chiba Central Medical Center
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Kudo Yoshiki
Department Of Pharmaceutical Sciences Tohoku University Hospital And Division Of Clinical Pharmacy G
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HISHINUMA TAKANORI
Division of Pharmacotherapy, Graduate School of Pharmaceutical Sciences, Tohoku University
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TOMIOKA Yoshihisa
Department of Pharmaceutical Sciences, Tohoku University Hospital and Division of Clinical Pharmacy,
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HISHINUMA Takanori
Department of Pharmaceutical Sciences, Tohoku University Hospital and Division of Clinical Pharmacy,
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HAYASHI Tetsuro
Department of Pharmaceutical Sciences, Tohoku University Hospital
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NIIZEKI Masahiro
Department of Pharmaceutical Sciences, Tohoku University Hospital
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Kudo Yoshiki
Department Of Obstetrics & Gynecology Hiroshima University
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Mizugaki Michinao
Department Of Clinical Pharmaceutics Tohoku Pharmaceutical University
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Hayashi T
Department Of Pharmacy Fujita Health University Hospital
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Tomioka Yoshihisa
Division Of Clinical Pharmacy Graduate School Of Pharmaceutical Sciences Tohoku University:laborator
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Tomioka Yoshihisa
Department Of Pharmaceutical Sciences Tohoku University Hospital
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Hishinuma Takanori
Department Of Hygienic Chemistry Pharmaceutical Institute Tohoku University
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Mizugaki M
Department Of Clinical Pharmaceutics Tohoku Pharmaceutical University
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Mizugaki M
Department Of Pharmaceutical Sciences Tohoku University Hospital
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Nakamura Hitoshi
Department Of Cardiology Chiba Central Medical Center
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Hayashi Tetsuro
Department Of Pharmaceutical Sciences Tohoku University Hospital
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Hishinuma T
Division Of Clinical Pharmacy Graduate School Of Pharmaceutical Sciences Tohoku University
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Niizeki Masahiro
Department Of Pharmaceutical Sciences Tohoku University Hospital
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Nakamura H
Department Of Pharmaceutical Sciences Tohoku University Hospital
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Kudo Yoshiki
Department Of Neuropsychiatry Graduate School Of Medicine University Of Tokyo
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