Fas-Mediated Apoptosis is Enhanced by Glycyrrhizin without Alteration of Caspase-3-Like Activity
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概要
- 論文の詳細を見る
We demonstrate that glycyrrhizin (GL) enhanced Fas-mediated apoptotic body formation and DNA fragmentation in T cell lines although GL alone did not induce apoptosis. The enhancement effect of Fas-mediated apoptosis by GL was dose-dependent above 0.3 μM. Time course study revealed that simultaneous co-treatment of GL and anti-Fas antibody was crucial for the enhancement of apoptosis and pretreatment with GL was not effective. Anti-Fas antibody elicited caspase-3-like activity. However caspase-3-like activity with co-treatment of GL and anti-Fas antibody was the same level as the antibody alone. Glycyrrhetic acid, the aglycon of GL, did not enhance Fas-mediated apoptosis. The amphipathic property of GL might enable it to interact with the plasma membrance and lead to the enhancement of apoptosis.
- 公益社団法人日本薬学会の論文
- 1999-11-15
著者
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MIZUGAKI Michinao
Department of Clinical Pharmaceutics, Tohoku Pharmaceutical University
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TOMIOKA Yoshihisa
Department of Pharmaceutical Sciences, Tohoku University Hospital and Division of Clinical Pharmacy,
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ISHIWATA Shunji
Department of Pharmaceutical Sciences, Tohoku University Hospital and Division of Clinical Pharmacy,
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NIIZEKI Masahiro
Department of Pharmaceutical Sciences, Tohoku University Hospital
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Mizugaki Michinao
Department Of Clinical Pharmaceutics Tohoku Pharmaceutical University
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Mizugaki Michinao
Dept. Pharmaceutical Sciences Akita University
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Suzuki N
Laboratory Of Pharmacotherapeutics Department Of Pharmaceutical Sciences Josai International Univers
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NAKASHITA Kei
Department of Pharmaceutical Sciences, Tohoku University Hospital
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NOZAKI Seishiro
Pharmacy Division, Ohta Nishinouchi Hospital
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Nozaki Seishiro
Department Of Pharmaceutical Sciences Tohoku University Hospital And Division Of Clinical Pharmacy G
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Nozaki Seishiro
Department Of Pharmacy Ohta Nishinouchi Hospital
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OZAWA Yasuko
Department of Pharmaceutical Sciences, Tohoku University Hospital
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Ishiwata Shunji
Department Of Pharmaceutical Sciences Tohoku University Hospital And Division Of Clinical Pharmacy G
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Ishiwata Shunji
Faculty Of Pharmaceutical Sciences Kinki University
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Ishiwata Shunji
Department Of Bioanalytical Pharmaceutics Faculty Of Pharmaceutical Sciences Kinki University
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Tomioka Yoshihisa
Division Of Clinical Pharmacy Graduate School Of Pharmaceutical Sciences Tohoku University:laborator
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Tomioka Yoshihisa
Department Of Pharmaceutical Sciences Tohoku University Hospital
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Mizugaki M
Department Of Clinical Pharmaceutics Tohoku Pharmaceutical University
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Mizugaki M
Department Of Pharmaceutical Sciences Tohoku University Hospital
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Nakashita Kei
Department Of Pharmaceutical Sciences Tohoku University Hospital
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Niizeki Masahiro
Department Of Pharmaceutical Sciences Tohoku University Hospital
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