Fas-Mediated Apoptosis is Enhanced by Glycyrrhizin without Alteration of Caspase-3-Like Activity

スポンサーリンク

概要

• 論文の詳細を見る

• We demonstrate that glycyrrhizin (GL) enhanced Fas-mediated apoptotic body formation and DNA fragmentation in T cell lines although GL alone did not induce apoptosis. The enhancement effect of Fas-mediated apoptosis by GL was dose-dependent above 0.3 μM. Time course study revealed that simultaneous co-treatment of GL and anti-Fas antibody was crucial for the enhancement of apoptosis and pretreatment with GL was not effective. Anti-Fas antibody elicited caspase-3-like activity. However caspase-3-like activity with co-treatment of GL and anti-Fas antibody was the same level as the antibody alone. Glycyrrhetic acid, the aglycon of GL, did not enhance Fas-mediated apoptosis. The amphipathic property of GL might enable it to interact with the plasma membrance and lead to the enhancement of apoptosis.

• 公益社団法人日本薬学会の論文
• 1999-11-15

著者

• MIZUGAKI Michinao

  Department of Clinical Pharmaceutics, Tohoku Pharmaceutical University

• TOMIOKA Yoshihisa

  Department of Pharmaceutical Sciences, Tohoku University Hospital and Division of Clinical Pharmacy,

• ISHIWATA Shunji

  Department of Pharmaceutical Sciences, Tohoku University Hospital and Division of Clinical Pharmacy,

• NIIZEKI Masahiro

  Department of Pharmaceutical Sciences, Tohoku University Hospital

• Mizugaki Michinao

  Department Of Clinical Pharmaceutics Tohoku Pharmaceutical University

• Mizugaki Michinao

  Dept. Pharmaceutical Sciences Akita University

• Suzuki N

  Laboratory Of Pharmacotherapeutics Department Of Pharmaceutical Sciences Josai International Univers

• NAKASHITA Kei

  Department of Pharmaceutical Sciences, Tohoku University Hospital

• NOZAKI Seishiro

  Pharmacy Division, Ohta Nishinouchi Hospital

• Nozaki Seishiro

  Department Of Pharmaceutical Sciences Tohoku University Hospital And Division Of Clinical Pharmacy G

• Nozaki Seishiro

  Department Of Pharmacy Ohta Nishinouchi Hospital

• OZAWA Yasuko

  Department of Pharmaceutical Sciences, Tohoku University Hospital

• Ishiwata Shunji

  Department Of Pharmaceutical Sciences Tohoku University Hospital And Division Of Clinical Pharmacy G

• Ishiwata Shunji

  Faculty Of Pharmaceutical Sciences Kinki University

• Ishiwata Shunji

  Department Of Bioanalytical Pharmaceutics Faculty Of Pharmaceutical Sciences Kinki University

• Tomioka Yoshihisa

  Division Of Clinical Pharmacy Graduate School Of Pharmaceutical Sciences Tohoku University:laborator

• Tomioka Yoshihisa

  Department Of Pharmaceutical Sciences Tohoku University Hospital

• Mizugaki M

  Department Of Clinical Pharmaceutics Tohoku Pharmaceutical University

• Mizugaki M

  Department Of Pharmaceutical Sciences Tohoku University Hospital

• Nakashita Kei

  Department Of Pharmaceutical Sciences Tohoku University Hospital

• Niizeki Masahiro

  Department Of Pharmaceutical Sciences Tohoku University Hospital

関連論文

• Effect of Acarbose Taken Just before and after a Meal on Plasma Glucose Level in Japanese Healthy Subjects
• 日本人におけるHNF4αの遺伝子多型の同定及びハプロタイプ構造の解析
• Genotyping of Single Nucleotide Polymorphisms (SNPs) Influencing Drug Response by Competitive Allele-specific Short Oligonucleotide Hybridization (CASSOH) with Immunochromatographic Strip
• Design, Production, and Characterization of Recombinant Neocarzinostatin Apoprotein in Escherichia coli
• Phenobarbital Molecularly Imprinted Polymer Selectively Binds Phenobarbital
• Pharmaceutical Properties of Nifedipine from a Ground Mixture with Nifedipine, Casein, Magnesium Silicate and Cellulose Acetate Phthalate
• Effect of morpholino antisense oligonucleotide against lumican mRNA in human embryonic kidney (HEK) 293 cells
• Determination of urinary 12(S)-hydroxyeicosatetraenoic acid by liquid chromatography-tandem mass spectrometry with column-switching technique : sex difference in healthy volunteers and patients with diabetes mellitus
• Preparation of Neocarzinostatin Apoprotein Mutants and the Randomized Library on the Chromophore-Binding Cavity(Miscellaneous)
• 4 Pro-R Hydrogen of NADPH was Abstracted for Enzymatic Hydride Transfer by N-Ethylmaleimide Reductase of Yarrowia lipolytica
• Evidence of Autophosphorylation in Txk : Y91 Is an Autophosphorylation Site
• Methyl-vitamin B12 blocks the CD28 co-stimulatory pathway in human T cells and its possible therapeutic application for T cell-mediated diseases, including rheumatoid arthritis
• 日本人における Denaturing HPLC を用いたCYP2S1遺伝子の新規SNPスクリーニング
• Genotyping of the N-acetyltransferase2 Polymorphism in the Prediction of Adverse Drug Reactions to Isoniazid in Japanese Patients
• High Throughput Detection of Drug-Metabolizing Enzyme Polymorphisms by Allele-Specific Fluorogenic 5' Nuclease Chain Reaction Assay
• Detection Assay of Rare Variants of the Thiopurine Methyltransferase Gene by PCR-RFLP Using a Mismatch Primer in a Japanese Population
• Determination of Serum Concentrations of Glycyrrhizin in Humans by Semi-micro High-Performance Liquid Chromatography after Administration of a Therapeutic Dose
• Intra- and Inter-Day Variation of LTE4 Levels in Healthy Human Urine Using the Liquid Chromatography/Tandem Mass Spectrometric Method (質量分析総合討論会特集号)
• Determination of leukotriene E_4 in human urine using liquid chromatography-tandem mass spectrometry
• Preparation of a Monoclonal Antibody Specific for 5-Methyl-2'-deoxycytidine and Its Application for the Detection of DNA Methylation Levels in Human Peripheral Blood Cells
• A Sandwich Enzyme-linked Immunosorbent Assay for Δ^3, Δ^2-Enoyl-CoA Isomerase in Rat-Tissue Homogenates
• Comparison of Serum and Urinary Levels of Modified Nucleoside, 1-Methyladenosine, in Cancer Patients Using a Monoclonal Antibody-Based Inhibition ELISA
• Fas-Mediated Apoptosis is Enhanced by Glycyrrhizin without Alteration of Caspase-3-Like Activity
• Creatinine at the Evaluation of Urinary 1-Methyladenosine and Pseudouridine Excretion
• A 63 kDa Tumor Necrosis Factor Inhibitor Released from a Human Monocytic Leukemia Cell Line, THP-1
• MOLECULAR CLONING OF THE nemA GENE ENCODING N-ETHYLMALEIMIDE REDUCTASE FROM Escherichia coli
• Subcellular Distribution of Rat Liver NADPH-2,4-Dienoyl-CoA Reductase
• Production and Characterization of a Monoclonal Antibody to Capture Proteins Tagged with Lithocholic Acid
• Enantioselective immunorecognition of protein modification with optically active ibuprofen using polyclonal antibody
• P3-30 Demethylation of DNA in mouse gonocytes and clevage-like cell division
• Expression of DNA Methyltransferase (Dnmt1) in Testicular Germ Cells during Development of Mouse Embryo
• Increased Expression of Queuosine Synthesizing Enzyme, tRNA-Guanine Transglycosylase, and Queuosine Levels in tRNA of Leukemic Cells
• Satratoxin H Generates Reactive Oxygen Species and Lipid Peroxides in PC12 Cells(Pharmacology)
• Report on the preparation of deuterium-labelled aconitine and mesaconitine and their application to the analysis of these alkaloids from body fluids as internal standard
• Three Novel Single Nucleotide Polymorphisms (SNPs) of the CYP2B6 Gene in Japanese Individuals
• Human CYP4B1 Gene in the Japanese Population Analyzed by Denaturing HPLC
• Forensic Assessment of 16 Single Nucleotide Polymorphisms Analyzed by Hybridization Probe Assay
• Brain and Heart Specific Alteration of Methamphetamine (MAP) Distribution in MAP-Sensitized Rat
• Isolation of Bovine Serum Albumin Fragment P-9 and P-9-Mediated Fusion of Small Unilamellar Vesicles
• Construction of a System that Simultaneously Evaluates CYP1A1 and CYP1A2 Induction in a Stable Human-derived Cell Line using a Dual Reporter Plasmid
• Preparation of a Monoclonal Antibody Specific to Chum Salmon Growth Hormone

もっと見る 閉じる

スポンサーリンク