Brain and Heart Specific Alteration of Methamphetamine (MAP) Distribution in MAP-Sensitized Rat

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概要

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• The repeated administration of me t ham p beta mine (MAP) causes behavioral sensitization in animals. We previously reported that the high accumulation of MAP was observed in the MAP-sensitized animal brain, which suggested that this phenomenon is an important factor in the development or expression of behavioral sensitization. The purpose of the present study is to elucidate the MAP distribution in the MAP-sensitized rat using gas chromatography/mass spectrometry (GC/MS). As a result, the MAP distribution in the heart at 10min when showing a high accumulation of MAP in the MAP-sensitized rat brain was significantly higher than that of the control rat, whereas no significant differences in the liver, kidney, abdominal muscle, femoral muscle and blood were observed. In the brain and heart, there was no different distribution at I min, reflecting only the influx process from blood to brain and heart. On the contrary, there was the significant difference at 10 min, reflecting both the influx and efflux process, suggesting that the efflux process of MAP from brain or heart to blood may be slow due to MAP sensitization. In conclusion, it was clear that the brain and heart specific alteration of the MAP distribution occurred in the MAP sensitization. It was considered that the high accumulation of MAP in the MAP-sensitized rat brain may be related to the expression of behavioral sensitization and that the delayed efflux of MAP in the MAP-sensitized rat heart may be connected with the cardiac toxicity.

• 公益社団法人日本薬学会の論文
• 2003-04-01

著者

• HIRATSUKA Masahiro

  Department of Clinical Pharmaceutics, Tohoku Pharmaceutical University

• MIZUGAKI Michinao

  Department of Clinical Pharmaceutics, Tohoku Pharmaceutical University

• Yamasaki Toru

  東海大学 農学部

• Nakamura Hitoshi

  Department of Cardiology, Chiba Central Medical Center

• TERASAKI Tetsuya

  Department of Molecular Biopharmacy and Genetics, Graduate School of Pharmaceutical Sciences, Tohoku

• Goto J

  Tohoku Univ. Sendai Jpn

• Goto Junichi

  Department Of Surgery Asahikawa Medical College

• Goto J

  The Ion Engineering Research Institute Corporation

• Inoue Tomoko

  Department Of Pharmaceutical Sciences Tohoku University Hospital

• YAMAZAKI Toru

  Department of Physics, Aoyama Gakuin University

• Goto J

  Division Of Clinical Pharmacy Graduate School Of Pharmaceutical Sciences Tohoku University

• Terasaki Tetsuya

  Department Of Molecular Biopharmacy And Genetics Graduate School Of Pharmaceutical Sciences Tohoku U

• Mizugaki Michinao

  Department Of Clinical Pharmaceutics Tohoku Pharmaceutical University

• Mizugaki Michinao

  Dept. Pharmaceutical Sciences Akita University

• Hiratsuka Masahiro

  Department Of Clinical Pharmaceutics Tohoku Pharmaceutical University

• Hiratsuka Masahiro

  Faculty Of Pharmaceutical Sciences Tohoku University

• Hiratsuka Masahiro

  Department Of Surgery Center For Adult Diseases

• Yamazaki Toru

  Department Of Cardiology Surugadai Nihon University Hospital

• Hishinuma Takanori

  Department Of Hygienic Chemistry Pharmaceutical Institute Tohoku University

• Mizugaki M

  Department Of Clinical Pharmaceutics Tohoku Pharmaceutical University

• Mizugaki M

  Department Of Pharmaceutical Sciences Tohoku University Hospital

• Nakamura Hitoshi

  Department Of Cardiology Chiba Central Medical Center

• Goto Junichi

  Department Of Pharmaceutical Sciences Tohoku University Hospital : Department Of Clinical Pharmacy G

• Ido Tatsuo

  Department Of Radiopharmaceuiical Chemistry Graduate School Of Pharmaceutical Sciences Tohoku Univer

• Hiratsuka Masahiro

  Laboratory Of Pharmacotherapy Of Life-style Related Disease Graduate School Of Pharmaceutical Scienc

• Hiratsuka Masahiro

  Department Of Medical Genetics Tohoku University School Of Medicine

• NAKAGAWA Nakato

  Department of Pharmaceutical Sciences, Tohoku University Hospital

• HISINUMA Takanori

  Department of Pharmaceutical Sciences, Tohoku University Hospital

• TUSKAMOTO Hiroki

  Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Tohoku University

• Yamazaki Toru

  Department Of Clinical Pharmacy Graduate School Of Pharmaceutical Sciences Tohoku University

• Hisinuma Takanori

  Department Of Pharmaceutical Sciences Tohoku University Hospital : Department Of Clinical Pharmacy G

• Hiratsuka Masahiro

  Laboratory Of Pharmacotherapy Of Life-style Related Diseases Graduate School Of Pharmaceutical Scien

• Nakagawa Nakato

  Department Of Pharmaceutical Sciences Tohoku University Hospital : Department Of Radiopharmaceuiical

• Terasaki Tetsuya

  Department Of Molecular Biopharmacy And Genetics Graduate School Of Pharmaceutical Sciences Tohoku U

• Tuskamoto Hiroki

  Department Of Clinical Pharmacy Graduate School Of Pharmaceutical Sciences Tohoku University

• Yamazaki Toru

  Department Of Applied Chemistry School Of Science And Engineering Waseda University

• Goto Junichi

  Department Of Pharmaceutical Sciences Tohoku University Hospital

• Nakamura Hitoshi

  Department Of Pharmaceutical Sciences Tohoku University Hospital

• Goto Junichi

  Department of Pharmaceutical Sciences, Tohoku University Hospital

• Nakagawa Naoto

  Department of Pharmaceutical Sciences, Tohoku University Hospital

• Hiratsuka Masahiro

  Department of Applied Chemistry, Faculty of Engineering, Chiba University

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