Effect of Mixing Method on the Mixing Degree during the Preparation of Triturations
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概要
- 論文の詳細を見る
By using lactose colored with erythrocin, we investigated the effects of mixing methods on mixing degree during the preparation of trituration with a mortar and pestle. The extent of powder dilution was set to 4 to 64 fold in the experiments. We compared the results obtained by using two methods: (1) one-step mixing of powders after addition of diluents and (2) gradual mixing of powders after addition of diluents. As diluents, we used crystallized lactose and powdered lactose for the preparation of trituration. In the preparation of 64-fold trituration, an excellent degree of mixing was obtained, with CV values of less than 6.08%, for both preparation methods and for the two kinds of diluents. The mixing of two kinds of powders whose distributions of particle sizes were similar resulted in much better degree of mixing, with CV values of less than 3.0%. However, the concentration of principal agents in 64-fold trituration was reduced by 20% due to the adsorption of dye to the apparatus. Under conditions in which a much higher dilution rate and/or much better degree of dilution was required, it must be necessary to dilute powders with considering their physicality and to determine the concentrations of principal agents after the mixing.
- 公益社団法人日本薬学会の論文
- 2004-03-01
著者
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中村 均
Departments of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of To
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Suzuki Hiroshi
Department of Engineering and Applied Science, Faculty of Science and Technology, Sophia University
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柳原 良次
Department of Pharmacy, University of Tokyo Hospital, Faculty of Medicine, University of Tokyo
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Nakamura Hitoshi
Department of Cardiology, Chiba Central Medical Center
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IGA Tatsuji
Department of Pharmacy, University of Tokyo Hospital, Faculty of Medicine, University of Tokyo
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KARIYA Satoru
Department of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Chiba University
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Kariya S
Department Of Hospital Pharmacy Tokyo Postal Service Agency Hospital
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Kariya Satoru
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Chiba University
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Komada Fusao
Japan And Department Of Drug Informatics Faculty Of Pharmaceutical Sciences Jyosai University
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Komada Fusao
Department Of Pharmacy Kyoto University Hospital Faculty Of Medicine Kyoto University
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Kawabata Haruno
Japan And Department Of Drug Informatics Faculty Of Pharmaceutical Sciences Jyosai University
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Iga Tatsuji
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University:department
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Iga Tatsuji
Department Of Pharmacy The University Of Tokyo Hospital Faculty Of Medicine The University Of Tokyo
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Komada F
Department Of Pharmacy Kobe University School Of Medicine
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Saitoh Yukiya
Japan And Department Of Drug Informatics Faculty Of Pharmaceutical Sciences Jyosai University
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Nakamura Hitoshi
Department Of Cardiology Chiba Central Medical Center
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UCHINO Katsuyoshi
Departmentof Pharmacy, Tokyo Teishin Hospital
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Suzuki Hiroshi
Department Of Allergy And Immunology National Research Institute For Child Health & Development
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Uchino Katsuyoshi
Department Of Hospital Pharmacy Tokyo Postal Service Agency Hospital
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YANAGIHARA Yoshitsugu
Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tok
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SEKIGUCHI Hiroko
Department of Hospital Pharmacy, Tokyo Postal Service Agency Hospital
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OHTANI Michiteru
Department of Hospital Pharmacy, Tokyo Postal Service Agency Hospital
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Sekiguchi Hiroko
Department Of Hospital Pharmacy Tokyo Postal Service Agency Hospital
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Ohtani Michiteru
Department Of Hospital Pharmacy Tokyo Postal Service Agency Hospital
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Nakamura H
Univ. Tokyo Tokyo Jpn
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関口 寛子
Department of Hospital Pharmacy, Tokyo Postal Service Agency Hospital
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YANAGIHARA Yoshitsugu
Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo
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