Size Characteristics of Liposomes Formed in a Micro-Tube
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概要
- 論文の詳細を見る
The characteristics of liposome formation in a micro-tube have been studied to develop a novel production method that forms the liposomes with a desired size homogeneously. In this method, the inner wall of the micro-tube was used to spread the liposomal lipid on. Then, instead of conventional rigorous agitation, an aqueous solution was fed through the tube, which peeled off the thin lipid layer formed liposomes. This resulted in a sharp peak in the size-distribution profile, and the size of liposomes was found to be dependent on the flow velocity and on the micro-tube size. Moreover, the yield of the liposomes of the desired size in our method was much higher than that in the conventional method, because our method produced liposomes uniform in size. From these findings, we concluded that the friction drag in the micro-tube is applicable for the efficient production of liposomes and a microfluidics device consisting of micro-tubes is a promising tool in the production of liposomal formulations.
- 社団法人 化学工学会の論文
- 2008-08-01
著者
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Usui Hiromoto
Department of Chemical Science and Engineering, Kobe University
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Suzuki Hiroshi
Department of Engineering and Applied Science, Faculty of Science and Technology, Sophia University
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KOMODA Yoshiyuki
Department of Chemical Science and Engineering, Kobe University
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Katsuda Tomohisa
Department of Chemical Science and Engineering, Graduate School of Engineering, Kobe University
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薄井 洋基
神戸大学
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Usui Hiromoto
Dep. Of Chemical Sci. And Engineering Kobe Univ.
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Usui H
Yamaguchi Univ. Ube Jpn
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薄井 洋基
神戸大
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Katsuda Tomohisa
Department Of Chemical Science And Engineering Graduate School Of Engineering Kobe University
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Katsuda Tomohisa
Department Of Chemical Science And Engineering Kobe University
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薄井 洋基
Dep. Of Chemical Sci. And Engineering Kobe Univ.
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HAMAMURA Jun-ya
Department of Chemical Science and Engineering, Kobe University
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KATOH Sigeo
Department of Chemical Science and Engineering, Kobe University
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Suzuki Hiroshi
Department Of Allergy And Immunology National Research Institute For Child Health & Development
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Hamamura Jun-ya
Department Of Chemical Science And Engineering Kobe University
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Usui Hiromoto
Department Of Applied Chemistry And Chemical Engineering Yamaguchi University
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Katoh Sigeo
Department Of Chemical Science And Engineering Kobe University
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Komoda Yoshiyuki
Department Of Chemical Science And Engineering Kobe University
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Komoda Yoshiyuki
Department Of Chemical Science And Engineering Graduate School Of Engineering Science Osaka Universi
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Suzuki Hiroshi
Department Of Chemical Science And Engineering Kobe University
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