Effect of Particle Size on Mixing Degree in Dispensation
スポンサーリンク
概要
- 論文の詳細を見る
By using lactose colored with erythrocin, we examined the effect of particle size on mixing degree during the preparation of triturations with a mortar and pestle. We used powders with different distributions of particle sizes, i.e., powder that passed through 32-mesh but was trapped on a 42-mesh sieve (32/42-mesh powder), powder that passed through a 42-mesh sieve but was trapped on a 60-mesh sieve (42/60-mesh powder), powder that passed through a 60-mesh sieve but was trapped on a 100-mesh sieve (60/100-mesh powder), and powder that passes through a 100-mesh sieve (>100mesh powder). The mixing degree of colored powder and non-colored powder whose distribution of particle sizes was the same as that of the colored powder was excellent. The coefficient of variation (CV) value of the mixing degree was 6.08% after 40 rotations when colored powder was mixed with non-colored powder that both passed through a 100-mesh sieve. The CV value of the mixing degree was low in the case of mixing of colored and non-colored powders with different particle size distributions. After mixing, about 50% of 42/60-mesh powder had become smaller particles, whereas the distribution of particle sizes was not influenced by the mixing of 60/100-mesh powder. It was suggested that the mixing degree is affected by distribution of particle sizes. It may be important to determine the mixing degrees for drugs with narrow therapeutic ranges.
- 公益社団法人日本薬学会の論文
- 2004-03-01
著者
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中村 均
Departments of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of To
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柳原 良次
Department of Pharmacy, University of Tokyo Hospital, Faculty of Medicine, University of Tokyo
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Kariya S
Department Of Hospital Pharmacy Tokyo Postal Service Agency Hospital
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Iga Tatsuji
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University:department
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Iga Tatsuji
Department Of Pharmacy The University Of Tokyo Hospital Faculty Of Medicine The University Of Tokyo
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Nakamura Hitoshi
Department Of Cardiology Chiba Central Medical Center
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Suzuki Hiroshi
Department Of Allergy And Immunology National Research Institute For Child Health & Development
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Uchino Katsuyoshi
Department Of Hospital Pharmacy Tokyo Postal Service Agency Hospital
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YANAGIHARA Yoshitsugu
Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tok
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OHTANI Michiteru
Department of Hospital Pharmacy, Tokyo Postal Service Agency Hospital
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SEKIGUCHI Hiroko
Japan and Department of Hospital Pharmacy, Tokyo Postal Service Agency Hospital
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OHTANI Michiteru
Japan and Department of Hospital Pharmacy, Tokyo Postal Service Agency Hospital
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KARIYA Satoru
Japan and Department of Hospital Pharmacy, Tokyo Postal Service Agency Hospital
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UCHINO Katsuyoshi
Japan and Department of Hospital Pharmacy, Tokyo Postal Service Agency Hospital
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Sekiguchi Hiroko
Department Of Hospital Pharmacy Tokyo Postal Service Agency Hospital
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Ohtani Michiteru
Department Of Hospital Pharmacy Tokyo Postal Service Agency Hospital
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Nakamura H
Univ. Tokyo Tokyo Jpn
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関口 寛子
Japan and Department of Hospital Pharmacy, Tokyo Postal Service Agency Hospital
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YANAGIHARA Yoshitsugu
Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo
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