EFFECT OF EXPERIMENTAL ACUTE RENAL FAILURE ON INTRINSIC RENAL TUBULAR SECRETORY CLEARANCE OF ORGANIC CATIONS IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
Effect of experimental acute renal failure (EARF) on the intrinsic renal tubular secretory clearance (CL^<SCN>_<int>) of tetraethylammonium bromide (TEA) and N^1-methylnicotinamide (NMN) was examined in rats treated with glycerol, folate, salicylate, uranium and gentamicin. The values of CL^<SCN>_<int> was calculated by an equation incorporating the determinants of the renal clearance (CL_r), i.e., renal tubular secretory clearance (CL^<SCN>_r), glomerular filtration rate (GFR), renal plasma flow (RPF), free fraction of the drug in plasma (f_p) and fraction (F_<reabs>) of the drug reabsorbed after filtration and secretion in the urine. In the EARF-rats, the values of CL^<SCN>_<int>of NMN and TEA were decreased by 0.017-0.575 times and by 0.005-0.737 times as compared to those of the normal rats, respectively. It was suggested that the decreases in CL^<SCN>_r of both NMN and TEA were due not to the decrease in RPF, but to that in CL^<SCN>_<int>.
- 公益社団法人日本薬学会の論文
著者
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Sawada Yasufumi
Faculty Of Pharmaceutical Sciences Tokushima Bunri University:faculty Of Pharmaceutical Sciences Uni
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Hanano M
Department Of Pharmaceutics College Of Pharmacy Nihon University
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Hanano Manabu
Faculty Of Pharmaceutical Science University Of Tokyo
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Iga Tatsuji
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University:department
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Iga Tatsuji
Faculty Of Pharmaceutical Sciences University Of Tokyo
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Iga T
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University:department
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SHIM CHANG-KOO
(Present address) College of Pharmacy Seoul National University
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