SIGNIFICANCE OF 17-HYDROXYCORTICOSTEROIDS GLUCURONIDE IN URINE AS AN INDEX OF SALICYLAMIDE GLUCURONIDATION IN GUINEA PIGS
スポンサーリンク
概要
- 論文の詳細を見る
The glucuronidation of 17-hydroxycorticosteroids (17-OHCS) and its effectiveness as an index of salicylamide (SAM) glucuronidation were examined in guinea pigs, the same cortisol type animals as man, treated with carbon tetrachloride (CCl_4), D-galactosamine, phenobarbital, D, L-ethionine and alloxan. There was not a statistically significant correlation between the plasma clearance of SAM glucuronidation (CL_<glu>) and the urinary excretion ratio of 17-OHCS glucuronide to total 17-OHCS in the intact, and CCl_4,D-galactosamine, alloxan and D, L-ethionine treated guinea pigs (r=0.158). However, there was a statistically significant correlation between the CL_<glu> and the clearance of 17-OHCS glucuronidation obtained as urinary 17-OHCS glucuronide/plasma cortisol concentration (r=0.738,p < 0.1). It was proposed that the clearance of 17-OHCS glucuronide metabloized from endogenous cortisol could be used as an index to assess the drug glucuronidation activity.
- 公益社団法人日本薬学会の論文
著者
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Sawada Yasufumi
Faculty Of Pharmaceutical Sciences Tokushima Bunri University:faculty Of Pharmaceutical Sciences Uni
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HAYASHI Masahiro
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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HANANO Manabu
Faculty of Pharmaceutical Sciences, University of Tokyo
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AWAZU SHOJI
Faculty of Pharmaceutical Science, University of Tokyo
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Hanano Manabu
Faculty Of Pharmaceutical Sciences University Of Tokyo
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Hanano Manabu
Faculty Of Pharmaceutical Science University Of Tokyo
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Awazu Shoji
Department Of Biopharmaceutics Tokyo College Of Pharmacy:department Of Pharmaceutics Research Center
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Awazu Shoji
Faculty Of Pharmaceutical Sciences University Of Tokyo:(present Address)tokyo College Of Pharmacy
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Awazu Shoji
Faculty Of Pharmaceutical Science University Of Tokyo:(present Address)tokyo College Of Pharmacy
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Awazu Shoji
Department Of Biopharmaceutics Tokyo College Of Pharmacy
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Awazu S
Department Of Biopharmaceutics Tokyo College Of Pharmacy:department Of Pharmaceutics Research Center
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Hayashi Masahiro
Faculty Of Pharmaceutical Sciences University Of Tokyo:(present Address)tokyo College Of Pharmacy
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Hayashi Masahiro
Faculty Of Agriculture Miyazaki University
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