SOLVENT DRAG EFFECT IN DRUG INTESTINAL ABSORPTION. I. STUDIES ON DRUG AND D_2O ABSORPTION CLEARANCES
スポンサーリンク
概要
- 論文の詳細を見る
It was shown that the intestinal absorption clearance of D_2O (CL_<D_2O>) could be a more appropriate index to study the solvent drag effect than water volume flow which was the difference between water influx and outflux in the intestinal lumen. Then, the correlation between the intestinal abosrption clearances of drugs (CL_<drug>) and CL_<D_2O> were studied using the in situ recirculating method in the rat small intestine. The drugs used were low molecular drugs, that is, benzoic acid, salicylic acid, p-hydroxybenzoic acid and antipyrine, and comparably high molecular drugs, that is, cephalexin (CEX), cefroxadine (CXD) and cephalothin (CET). CL_<drug> and CL_<D_2O> were obtained in hypertonic, isotonic and hypotonic perfused solution adjusted with sodium chloride. Consequently, the correlations for all drugs except CET were significant and high solvent drag effects were observed. CL_<drug> of benzoic acid, salicylic acid and antipyrine were approximately equal to CL_<D_2O>, suggesting that the intestinal mucosa could not distinguish these lower molecular drugs from water. For the high molecular drugs such as cephalosporins, however, some extent of reflection from the membrane was certainly found in CEX and CXD, and the extent in CET was assumed much larger than CEX and CXD, resulting that the contribution of solvent drag in CET could not be found. Consequently, it was suggested that the solvent drag had some important role in the intestinal absorption of cephalosporins.
- 公益社団法人日本薬学会の論文
著者
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Hanano M
Department Of Pharmaceutics College Of Pharmacy Nihon University
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Hanano Manabu
Faculty Of Pharmaceutical Science University Of Tokyo
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Awazu Shoji
Faculty Of Pharmaceutical Sciences University Of Tokyo:(present Address)tokyo College Of Pharmacy
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Kimura A
Photonic And Wireless Devices Research Laboratories Nec Corporation
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Awazu Shoji
Deparment Of Biopharmaceutics Tokyo College Of Pharmacy
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Karino Akira
Department Of Biopharmaceutics Tokyo College Of Pharmacy:department Of Pharmaceutics Research Center
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Hayashi Masahiro
Department Of Biological Production And Enviromental Science Faculty Of Agriculture The University O
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澤山 茂
東京農大 栄養
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Horie Toshiharu
Department Of Biopharmaceutics Graduate School Of Pharmaceutical Sciences Chiba University
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MINAMI HARUO
Faculty of Pharmaceutical Sciences, University of Tokyo
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Minami Haruo
Faculty Of Pharmaceutical Sciences University Of Tokyo
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Hayashi Masahiro
Department of Absorption and Pharmacokinetics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
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