FACILITATED TRANSPORT OF BENZYLPENICILLIN THROUGH THE BLOOD-BRAIN BARRIER IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
The unidirectional influx of benzylpenicillin through the bloodbrain barrier was examined with an in situ rat brain perfusion technique using purified [^3H] benzylpenicillin. The major transport system of benzylpenicillin through the blood-brain barrier was via a saturable process with a one-half saturation concentration of approximately 8-30μM. This transport system was significantly inhibited by probenecid (100μM) and ceftriaxone (2 mM), indicating that the transport system may be shared by some organic anions including third generation cephalosporin antibiotics. These findings suggest that concomitant administration of β-lactam antibiotics could produce a drug interaction to alter the drug penetration into the central nervous system.
- 社団法人日本薬学会の論文
著者
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Sugiyama Yuichi
Grad. Sch. Pharm. Sci. Univ. Tokyo
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Suzuki Hiroshi
Faculty of Science, Kyoto University
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Sawada Y
Univ. Tokyo Tokyo Jpn
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Sawada Yasufumi
Faculty Of Pharmaceutical Sciences Tokushima Bunri University:faculty Of Pharmaceutical Sciences Uni
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HANANO Manabu
Faculty of Pharmaceutical Sciences, University of Tokyo
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SUGIYAMA Yuichi
Faculty of Pharmaceutical Sciences, University of Tokyo
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IGA Tatsuji
Faculty of Pharmaceutical Sciences, University of Tokyo
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IGA Tatsuji
International University of Health and Welfare
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Hanano Manabu
Faculty Of Pharmaceutical Sciences University Of Tokyo
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Hanano M
Department Of Pharmaceutics College Of Pharmacy Nihon University
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Hanano M
Department Of Pharmaceutical Science College Of Pharmacy Nihon University
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Hanano Manabu
Faculty Of Pharmaceutical Science University Of Tokyo
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Sugiyama Yuichi
Faculty Of Pharmaceutical Sciences University Of Tokyo
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Iga T
Department Of Pharmacy University Of Tokyo Hospital
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Iga Tatsuji
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University:department
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Iga Tatsuji
Faculty Of Pharmaceutical Sciences University Of Tokyo
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Hanano M
Faculty Of Pharmaceutical Sciences University Of Tokyo
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Hanano Manabu
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University:department
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Sato Hiroaki
Fac. Of Pharm. Sci. Univ. Of Tokyo
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Iga T
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University:department
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Iga Tatsuji
Department Of Pharmacy Faculty Of Pharmaceutical Sciences University Of Tokyo
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Sugiyama Yuichi
Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Iga Tatsuji
Division Of Gastroenterology Department Of Medicine Kurume University School Of Medicine
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IGA TATSUJI
Department of Pharmaceutics, University of Tokyo Hospital, University of Tokyo
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