ESTIMATION OF RENAL BLOOD FLOW BY USE OF ENDOGENOUS N^1-METHYLNICOTINAMIDE IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
The usefulness of the renal clearance of endogenous N^1-methylnicotinamide (NMN) as a probe for estimating the renal blood flow (RBF) was examined in rats. And the effect of experimental acute renal failure (ERF) on RBF was also examined in rats treated with glycerol, folate, salicylate, uranium and gentamicin by using this method. No significant difference was shown between the values of RBF determined by the NMN method and conventional p-aminohippurate (PAH) method in both the in tact (control) and glycerol-ERF rats, suggesting the usefulness of the NMN method in determining RBF. No significant difference was also shown in RBF between the control and all ERF-rats studied, through significant decreases in the renal clearance of NMN and renal extraction ratio (ER) were observed in the ERF-rats except the gentamicin-treated rats. It was suggested that the endogenous NMN would be a useful probe to estimate RBF without constant infusion of exogenous substances.
- 公益社団法人日本薬学会の論文
著者
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Sawada Yasufumi
Faculty Of Pharmaceutical Sciences Tokushima Bunri University:faculty Of Pharmaceutical Sciences Uni
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Hanano Manabu
Faculty Of Pharmaceutical Sciences University Of Tokyo
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Hanano M
Department Of Pharmaceutics College Of Pharmacy Nihon University
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Hanano M
Department Of Pharmaceutical Science College Of Pharmacy Nihon University
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Hanano Manabu
Faculty Of Pharmaceutical Science University Of Tokyo
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Iga Tatsuji
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University:department
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Iga Tatsuji
Faculty Of Pharmaceutical Sciences University Of Tokyo
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Hanano M
Faculty Of Pharmaceutical Sciences University Of Tokyo
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Hanano Manabu
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University:department
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SHIM CHANG-KOO
Faculty of Pharmaceutical Sciences, University of Tokyo
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Iga Tatsuji
Division Of Gastroenterology Department Of Medicine Kurume University School Of Medicine
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