THE STUDY ON THE BIOLOGICAL FATE OF PARABEN AT THE DOSE OF PRACTICAL USAGE IN RAT. I. THE METABOLISM AND EXCRETION OF ETHYL p-HYDROXYBENZOATE (ETHYLPARABEN) AND p-HYDROXYBENZOIC ACID
スポンサーリンク
概要
- 論文の詳細を見る
The biological fates of ethylparaben (EP) which has been widely used as a preservatives for the pharmaceutical preparations and foods, and p-hydroxybenzoic acid (HB) which is the parent compound of EP, were investigated at the dose of practical usage (2 mg/kg) in rats. Although both EP and HB were metabolized to glycine conjugate (M1), ester type glucuronide (M3) and sulfate (M4) of HB and excreted in the urine and bile, the excretion ratios were different as compared with the results of higher dose experiments carried out by other authors, and a route dependency was also found in the rate of excretion in the bile. The excretion data obtained in this study are shown as follows : In intravenous administration of EP, the excreted total activity was 91.3% per dose in the urine and 5.97% in the bile, and percentages per dose of the major metabolites excreted in the urine were 8.14% of HB, 39.6% of M1,29.5% of M3 and 6.48% of M4. In intraduodenal administration of EP, the excreted total activity (83.5%) and the activity excreted as HB (3.51%) decreased compared with the intravenous administration. In the HB administration, the route dependency of the total activity was not found, but a decrease in the excretion of HB in the intraduodenal administration was found. The excretion of total radioactivity almost ceased by 5 hr and the biological halflives obtained from the β-phase of the sigma-minus plots of the metabolites excreted in the urine were 40-70 min. The result obtained in this study differ from those of other authors at the high dose experiments.
- 公益社団法人日本薬学会の論文
著者
-
Kiwada Hiroshi
Faculty Of Pharmaceutical Science University Of Tokyo:(present Address)faculty Of Pharmaceutical Sci
-
HANANO Manabu
Faculty of Pharmaceutical Sciences, University of Tokyo
-
KIWADA HIROSHI
(Present address)Faculty of Pharmaceutical Sciences, Science University of Tokyo
-
AWAZU SHOJI
(Present adress)Tokyo College of Pharmacy
-
Hanano Manabu
Faculty Of Pharmaceutical Science University Of Tokyo
-
Awazu Shoji
Faculty Of Pharmaceutical Science University Of Tokyo:(present Address)tokyo College Of Pharmacy
関連論文
- 東京薬科大学における六年生教育第一期入学生を対象とした意識調査
- 自己乳化型O/Wマイクロエマルションの消化管吸収性向上化および安定化効果に対する粒子径の影響検討
- メチルプレドニゾロンの吸収部位特異性 : Efflux transporter との親和性
- (1→3)-β-D-グルカンの腸管吸収機構の解明
- 小腸虚血再灌流時の吸収制御因子の変動および抗酸化物質による制御
- 腸管吸収性および体内動態を予測する非侵襲的システムの開発
- 01-H-02 メチルプレドニゾロンの吸収部位特異性(薬物動態(TDM・投与設計等),医療薬学の扉は開かれた)
- Tight junction およびP-糖蛋白質の機能修飾に基づいた薬物吸収改善
- 新教育制度への期待と夢(ベランダ,発進する新しい薬学教育)
- 薬学部6年制設置基準への対応
- Effect of Cationic Liposomes in an in Vitro Transcription and Translation System
- Prediction of Absorbability of Poorly Water-soluble Drugs Based on Permeability Obtained through Modified In Vitro Chamber Method
- Prediction of the Pharmacokinetics of Cefodizime and Cefotetan in Humans from Pharmacokinetic Parameters in Animals
- RENAL HANDLING OF EPIDERMAL GROWTH FACTOR IN ISOLATED PERFUSED RAT KIDNEY
- COMPARATIVE ANALYSIS OF HEPATIC UPTAKE AND BILIARY EXCRETION OF VINCRISTINE AND VINBLASTINE IN PERFUSED RAT LIVER
- DOWN REGULATION OF EPIDERMAL GROWTH FACTOR (EGF) RECEPTOR IN THE PERFUSED RAT LIVER : RECOVERY OF THE CELL SURFACE FREE RECEPTOR
- Effect of Quinidine on the Hepatic Uptake of Digoxin in Guinea Pigs
- FACILITATED TRANSPORT OF BENZYLPENICILLIN THROUGH THE BLOOD-BRAIN BARRIER IN RATS
- Kinetic Analysis of the Positive Inotropic Action (PIA) of Ouabain in Isolated Perfused Rabbit Heart. Slow Onset of PIA and Slow Binding to Na^+, K^+-Adenosine Triphosphatase
- PHARMACOKINETIC STUDY OF 4-METHYLUMBELLIFERONE IN MICE
- KINETICAL ANALYSIS OF HEPATIC TRANSPORT OF EPIDERMAL GROWTH FACTOR (EGF) IN THE PERFUSED RAT LIVER
- COMPARATIVE UPTAKE OF CIMETIDINE BY RAT CHOROID PLEXUS BETWEEN THE LATERAL AND THE 4TH VENTRICLES
- PREDICTION OF SERUM CONCENTRATION TIME COURSE OF QUINIDINE IN HUMAN USING A PHYSIOLOGICALLY BASED PHARMACOKINETIC MODEL DEVELOPED FROM THE RAT
- PREDICTION OF THE PLASMA CONCENTRATION TIME COURSES OF VARIOUS DRUGS IN HUMANS BASED ON DATA FROM RATS
- KINETICS OF HEPATIC TRANSPORT OF 4-METHYLUMBELLIFERONE IN RATS : ANALYSIS BY MULTIPLE INDICATOR DILUTION METHOD
- KINETIC ANALYSIS OF RENAL TUBULAR TRANSPORT OF CIMETIDINE IN RATS BASED ON MULTIPLE INDICATOR DILUTION STUDIES
- 教育と研究から見た今後の薬剤学
- 薬学教育6年制スタートにあたって
- 移植手術成功には抗酸化物質の併用が必要!
- Effectiveness of Pirotiodecane, Absorption Enhancer, on Nasal Absorption in Rabbits
- KINETIC ANALYSIS OF DISPOSITION OF HUMAN EPIDERMAL GROWTH FACTOR (EGF) : ANALYSIS USING FRESHLY ISOLATED RAT HEPATOCYTE AND ANALYSIS OF RECEPTOR DYNAMICS IN ORGANS IN VIVO
- Kinetic Study on the Mechanism of Tissue Distribution of Vinblastine
- Characterization of Bovine Serum Factor Triggering the Lysis of Liposomes via Complement Activation
- Effect of Serum Components from Different Species on Destabilizing Hydrogenated Phosphatidylcholine-Based Liposomes
- In Vivo Studies on the Role of Complement in the Clearance of Liposomes in Rats and Guinea Pigs
- THE STUDY ON THE BIOLOGICAL FATE OF PARABEN AT THE DOSE OF PRACTICAL USAGE IN RAT. III. THE EFFECTS OF SALICYLIC ACID ON THE FATE OF ETHYL PARABEN
- THE STUDY ON THE BIOLOGICAL FATE OF PARABEN AT THE DOSE OF PRACTICAL USAGE IN RAT. II. THE PHARMACOKINETIC STUDY ON THE BLOOD CONCENTRATION AFTER THE ADMINISTRATION OF ETHYL PARABEN OF p-HYDROXYBENZOIC ACID
- THE STUDY ON THE BIOLOGICAL FATE OF PARABEN AT THE DOSE OF PRACTICAL USAGE IN RAT. I. THE METABOLISM AND EXCRETION OF ETHYL p-HYDROXYBENZOATE (ETHYLPARABEN) AND p-HYDROXYBENZOIC ACID
- Influence of Cigarette Smoke on the L-Ascorbic Acid Metabolism and the Activities of Drug-Metabolizing Enzyme in Rats
- 肝臓および腎臓における P-glycoprotein に対する小腸虚血再灌流の影響
- Assessment of Ileal Epithelial P-Glycoprotein Dysfunction Induced by Ischemia/Reperfusion using in vivo Animal Model
- Kinetic Analysis of the Interaction between Liposomes and the Complement System in Rat Serum : Re-evaluation of Size-Dependency
- INHIBITORY MECHANISM OF SULFAPHENAZOLE ON TOLBUTAMIDE ELIMINATION FROM PLASMA IN RAT
- Complement Dependent and Independent Liposome Uptake by Peritoneal Macrophages : Cholesterol Content Dependency
- KINETIC ANALYSIS OF THE UPTAKE PROCESS OF LIPOSOMES BY RES
- KINETIC STUDIES ON FORMATION AND BILIARY EXCRETION OF LIQUIRITIGENIN CONJUGATES IN RATS
- THE MECHANISM OF INTESTINAL TRANSPORT OF SULFAMETHOXAZOLE AND THE EFFECT OF CHLORPROMAZINE IN RAT EVERTED INTESTINE
- EFFECT OF CHLORPROMAZINE ON INTESTINAL ABSORPTION OF SULFAMETHOXAZOLE IN RATS
- NUCLEAR BINDING AS A DETERMINANT OF TISSUE DISTRIBUTION OF ADRIAMYCIN, DAUNOMYCIN, ADRIAMYCINOL, DAUNORUBICINOL AND ACTINOMYCIN D
- EFFECT OF THE AQUEOUS DIFFUSION LAYER ON THE INTESTINAL DRUG ABSORPTION IN SITU
- 酒石酸の新たな役割 : P-glycoprotein 機能修飾
- Regional Difference in P-glycoprotein Function in Rat Intestine
- Prediction of Glycyrrhizin Disposition in Rat and Man with Liver Failure by a Physiologically Based Pharmacokinetic Model
- QUANTITATIVE EVIDENCE FOR INTERSPECIES DIFFERENCE IN TISSUE DISTRIBUTION MECHANISM OF ADRIAMYCIN
- Effect of Serum on Dose-and Temperature-Dependent Hepatic Uptake of Multilamellar Vesicles (MLV)
- CONTRIBUTION OF P-GLYCOPROTEIN, ASSOCIATED WITH MULTIDRUG RESISTANCE, TO BILIARY EXCRETION OF VINCRISTINE : A KINETIC ANALYSIS
- TARGETING TO MONONUCLEAR PHAGOCYTE SYSTEM BY CETYLMANNOSIDE-MODIFIED LIPOSOMES
- SOLVENT DRAG EFFECT IN DRUG INTESTINAL ABSORPTION : STUDIES ON DRUG AND D_2O ABSORPTION CLEARANCES
- 1-ANILINO-8-NAPHTHALENE SULFONATE BINDING SITE ON HUMAN ERYTHROCYTE MEMBRANE USING FLUORESCENCE LIFETIME AND POLARIZATION
- SIGNIFICANCE OF 17-HYDROXYCORTICOSTEROIDS GLUCURONIDE IN URINE AS AN INDEX OF SALICYLAMIDE GLUCURONIDATION IN GUINEA PIGS
- COMPARATIVE HEPATIC TRANSPORT OF SULFOBROMOPHTHALEIN AND ITS GLUTATHIONE CONJUGATE IN RATS
- THE CORRELATION BETWEEN DRUG BINDING TO THE HUMAN ERYTHROCYTE AND ITS HEMOLYTIC ACTIVITY
- MULTIPLICITY OF SULFOBROMOPHTHALEIN-BINDING PROTEINS IN Y-FRACTION FROM RAT LIVER
- THE BINDING AND CONJUGATING ABILITIES OF THE Y-FRACTION FOR SULFOBROMOPHTHALEIN (BSP) IN CHRONIC CARBON TETRACHLORIDE-INTOXICATED RATS
- THE CORRELATION BETWEEN DRUG BINDING TO THE HUMAN ERYTHROCYTE MEMBRANE AND ITS HEMOLYTIC ACTIVITY, DETERMINED BY FLUORESCENT PROBE TECHNIQUES
- PHARMACOKINETIC STUDY OF 4-METHYLUMBELLIFERONE IN RATS : INFLUENCE OF DOSE ON ITS FIRST-PASS HEPATIC ELIMINATION
- PHYSIOLOGICAL PHARMACOKINETICS OF TOLBUTAMIDE-SULFONAMIDES INTERACTION IN RATS
- SATURABLE TRANSPORT OF CIMETIDINE FROM CEREBROSPINAL FLUID TO BLOOD IN RATS
- ESTIMATION OF RENAL BLOOD FLOW BY USE OF ENDOGENOUS N^1-METHYLNICOTINAMIDE IN RATS
- EFFECT OF PREGNANCY ON TISSUE DISTRIBUTION OF SALICYLATE IN THE RAT
- EFFECT OF EXPERIMENTAL ACUTE RENAL FAILURE ON INTRINSIC RENAL TUBULAR SECRETORY CLEARANCE OF ORGANIC CATIONS IN RATS
- PREDICTION OF RENAL SECRETORY CLEARANCE OF ORGANIC CATIONIC DRUGS BY ENDOGENOUS N^1-METHYLNICOTINAMIDE IN RATS WITH EXPERIMENTAL RENAL FAILURE
- PREDICTION OF RENAL TUBULAR SECRETION OF TETRAETHYLAMMONIUM BROMIDE BY USE OF ENDOGENOUS N^1-METHYLNICOTINAMIDE IN THE RAT
- EFFECT OF HEPARIN INJECTION ON PLASMA PROTEIN BINDING OF 1-ANILINO-8-NAPHTHALENESULFONATE AND SALICYLATE IN RATS
- SOLVENT DRAG EFFECT IN DRUG INTESTINAL ABSORPTION. II. STUDIES ON DRUG ABSORPTION CLEARANCE AND WATER INFLUX
- SOLVENT DRAG EFFECT IN DRUG INTESTINAL ABSORPTION. I. STUDIES ON DRUG AND D_2O ABSORPTION CLEARANCES
- INTERINDIVIDUAL DIFFERENCES IN THE PLASMA PROTEIN BINDING OF 1-ANILINO-8-NAPHTHALENESULFONATE AND PHENYLBUTAZONE IN RATS
- INTESTINAL ABSORPTION OF dl-α-TOCOPHEROL FROM BILE SALTS AND POLYSORBATE 80 MICELLAR SOLUTIONS IN RAT