THE STUDY ON THE BIOLOGICAL FATE OF PARABEN AT THE DOSE OF PRACTICAL USAGE IN RAT. III. THE EFFECTS OF SALICYLIC ACID ON THE FATE OF ETHYL PARABEN
スポンサーリンク
概要
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The biological fates of ethyl paraben were investigated after the simultaneous administration with salicylic acid. Those fates were compared with those of ethyl paraben alone obtained in the previous experiments. The biological fates of ethyl paraben after the simultaneous administration with salicylic acid were different from those of ethyl paraben alone as reported in the previous reports : The excretion of unconjugated p-hydroxybenzoic acid, which is a hydrolyzed product of ethyl paraben, increased and those of p-hydroxyhippuric acid, glycine conjugate of p-hydroxybenzoic acid, and p-hydroxybenzoyl glucuronide, its ester type glucuronide, decreased. The blood concentration patterns were considerably different from those of ethyl paraben alone, especially the elimination of every metabolite was delayed. Pharmacokinetic analyses on the data of blood concentration were carried out and the results also show the interaction of salicylic acid on the biological fate of ethyl paraben.
- 公益社団法人日本薬学会の論文
著者
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Kiwada Hiroshi
Faculty Of Pharmaceutical Science University Of Tokyo:(present Address)faculty Of Pharmaceutical Sci
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HANANO Manabu
Faculty of Pharmaceutical Sciences, University of Tokyo
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AWAZU SHOJI
Faculty of Pharmaceutical Science, University of Tokyo
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Hanano Manabu
Faculty Of Pharmaceutical Science University Of Tokyo
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Awazu Shoji
Faculty Of Pharmaceutical Science University Of Tokyo:(present Address)tokyo College Of Pharmacy
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Kiwada Hiroshi
Faculty Of Pharmaceutical Science The University Of Tokushima
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