THE CORRELATION BETWEEN DRUG BINDING TO THE HUMAN ERYTHROCYTE AND ITS HEMOLYTIC ACTIVITY
スポンサーリンク
概要
- 論文の詳細を見る
Cationic phenothiazine derivatives, anionic anthranilic acid derivatives and fluorescent probe 1-anilino-8-naphthalene sulfonate (ANS) which had hemolytic activities were used to investigate hemolysis of human erythrocyte. The observed hemolytic activities of drugs could divided into two categories : (1) the difference of the binding activity of drugs to the erythrocyte and (2) the difference of the membrane perturbation activity of drugs bound to the erythrocyte. The human erythrocyte had two kinds of binding sites for any drug used. The first site of them was already saturated before hemolysis occurred and the second site of them may play an important role in hemolysis by these drugs.
- 公益社団法人日本薬学会の論文
著者
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HANANO Manabu
Faculty of Pharmaceutical Sciences, University of Tokyo
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SUGIYAMA Yuichi
Faculty of Pharmaceutical Sciences, University of Tokyo
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AWAZU SHOJI
Faculty of Pharmaceutical Science, University of Tokyo
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Hanano M
Department Of Pharmaceutics College Of Pharmacy Nihon University
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Hanano Manabu
Faculty Of Pharmaceutical Science University Of Tokyo
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Sugiyama Yuichi
Faculty Of Pharmaceutical Sciences University Of Tokyo
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Awazu Shoji
Department Of Biopharmaceutics Tokyo College Of Pharmacy:department Of Pharmaceutics Research Center
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Awazu Shoji
Faculty Of Pharmaceutical Sciences University Of Tokyo:(present Address)tokyo College Of Pharmacy
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Awazu Shoji
Faculty Of Pharmaceutical Science University Of Tokyo:(present Address)tokyo College Of Pharmacy
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HORIE Toshiharu
Faculty of Pharmaceutical Sciences, Chiba University.
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Awazu S
Department Of Biopharmaceutics Tokyo College Of Pharmacy:department Of Pharmaceutics Research Center
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澤山 茂
東京農大 栄養
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Horie Toshiharu
Faculty Of Pharmaceutical Sciences University Of Tokyo:(present Address)tokyo College Of Pharmacy
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Horie Toshiharu
Faculty Of Pharmaceutical Sciences Chiba University.
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Sugiyama Yuichi
Faculty Of Pharmaceutical Sciences The University Of Tokyo
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