Quantitative Prediction of In Vivo Drug-drug Interactions from In Vitro Data : Effects of Active Transport of Inhibitors into the Liver

スポンサーリンク

概要

• 論文の詳細を見る
• 2000-08-01

著者

• SUZUKI Hiroshi

  Graduate School of Pharmaceutical Sciences, The University of Tokyo

• SUGIYAMA Yuichi

  Graduate School of Pharmaceutical Sciences, The University of Tokyo

• Sugiyama Yuichi

  Grad. Sch. Pharm. Sci. Univ. Tokyo

• Suzuki Hiroshi

  Graduate School Of Pharmaceutical Sciences The University Of Tokyo

• KANAMITSU Shin-ichi

  Section of Drug Metabolism Research, Naruto Research Institute, Otsuka Pharmaceutical Factory, Inc.

• SHINOZAKI Yutaka

  Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.

• ITO Kiyomi

  School of Pharmaceutical Sciences, Kitasato University

• IWATSUBO Takafumi

  Drug Metabolism Laboratories, Institute for Drug Development Research, Yamanouchi Pharmaceutical Co.

• Ito Kiyomi

  Sch. Pharm. Sci. Kitasato Univ.

• Ito Kiyomi

  School Of Pharmaceutical Sciences Kitasato University

• Shinozaki Yutaka

  Central Research Laboratories Zeria Pharmaceutical Co. Ltd.

• Sugiyama Yuichi

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• Kanamitsu Shin-ichi

  Fac. Of Pharm. Sci. Univ. Of Tokyo

• Sato Hiroaki

  Fac. Of Pharm. Sci. Univ. Of Tokyo

• Sugiyama Yuichi

  Graduate School Of Pharmaceutical Sciences The University Of Tokyo

• Iwatsubo Takafumi

  Inst. For Drug Dev. Res. Yamanouchi Pharmaceutical Co. Ltd.

• Sugiyama Yuichi

  Graduate School Of Pharmaceutical Sciences The Univ. Of Tokyo

• SUZUKI Hiroshi

  Graduate School of Engineering, Hokkaido University

• SUZUKI Hiroshi

  Graduate School of Computer Science and System Engineering Kyushu Institute of Technology

• Sugiyama Yuichi

  Graduate School of Industrial Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda-shi, Chiba 278-8510, Japan

関連論文

• Twelve Novel Single Nucleotide Polymorphisms in the CES2 Gene Encoding Human Carboxylesterase 2 (hCE-2)
• Novel Genetic Polymorphisms in the NR3C1 (Glucocorticoid receptor) Gene in a Japanese Population
• Twenty-six Novel Single Nucleotide Polymorphisms and their Frequencies of the NR113 (CAR) Gene in a Japanese Population
• Eight Novel Single Nucleotide Polymorphisms in ABCG2/BCRP in Japanese Cancer Patients Administered Irinotacan
• Eight Novel Single Nucleotide Polymorphisms in ABCG2/BCRP in Japanese Cancer Patients Administered Irinotacan
• Effect of Aminoguanidine on Lipopolysaccharide-Induced Changes in Rat Liver Transporters and Transcription Factors(Molecular and Cell Biology)
• Structure Analysis of Drag-Reducing Surfactant Rod-Like Micelles with Fluorescence Probe
• Biaxial Extensional Characteristics of Drag-Reducing Surfactant Solution
• Function of Uptake Transporters for Taurocholate and Estradiol 17β-D-Glucuronide in Cryopreserved Human Hepatocytes
• LASP FAMILY PROTEINS OF INVERTEBRATES(Cell Biology and Morphology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
• X-Ray Fractography Using Synchrotron Radiation : Residual Stress Distribution Just beneath Fatigue Fracture Surface
• Prediction of the Pharmacokinetics of Cefodizime and Cefotetan in Humans from Pharmacokinetic Parameters in Animals
• QUANTITATIVE RELATIONSHIP BETWEEN IN VIVO BENZODIAZEPINE RECEPTOR OCCUPANCY AND CEREBRAL METABOLIC CHANGE IN THE MOUSE
• RENAL HANDLING OF EPIDERMAL GROWTH FACTOR IN ISOLATED PERFUSED RAT KIDNEY
• BINDING, INTERNALIZATION AND DEGRADATION OF ATRIAL NATRIURETIC PEPTIDE IN ISOLATED CHOROID PLEXUS
• COMPARATIVE ANALYSIS OF HEPATIC UPTAKE AND BILIARY EXCRETION OF VINCRISTINE AND VINBLASTINE IN PERFUSED RAT LIVER
• DOWN REGULATION OF EPIDERMAL GROWTH FACTOR (EGF) RECEPTOR IN THE PERFUSED RAT LIVER : RECOVERY OF THE CELL SURFACE FREE RECEPTOR
• Effect of Quinidine on the Hepatic Uptake of Digoxin in Guinea Pigs
• FACILITATED TRANSPORT OF BENZYLPENICILLIN THROUGH THE BLOOD-BRAIN BARRIER IN RATS
• Kinetic Analysis of the Positive Inotropic Action (PIA) of Ouabain in Isolated Perfused Rabbit Heart. Slow Onset of PIA and Slow Binding to Na^+, K^+-Adenosine Triphosphatase
• THE TRANSPORT SYSTEM OF BENZYLPENICILLIN IN THE BLOOD-CEREBROSPINAL FLUID BARRIER
• THE EFFECT OF BASIC DRUGS ON THE HEPATIC TRANSPORT OF CARDIAC GLYCOSIDES IN RATS
• PHARMACOKINETIC STUDY OF 4-METHYLUMBELLIFERONE IN MICE
• KINETICAL ANALYSIS OF HEPATIC TRANSPORT OF EPIDERMAL GROWTH FACTOR (EGF) IN THE PERFUSED RAT LIVER
• THE TRANSPORT SYSTEM OF CIMETIDINE FROM THE RAT CEREBROSPINAL FLUID : IN VIVO AND IN VITRO STUDIES
• COMPARATIVE UPTAKE OF CIMETIDINE BY RAT CHOROID PLEXUS BETWEEN THE LATERAL AND THE 4TH VENTRICLES
• PREDICTION OF SERUM CONCENTRATION TIME COURSE OF QUINIDINE IN HUMAN USING A PHYSIOLOGICALLY BASED PHARMACOKINETIC MODEL DEVELOPED FROM THE RAT
• PREDICTION OF THE PLASMA CONCENTRATION TIME COURSES OF VARIOUS DRUGS IN HUMANS BASED ON DATA FROM RATS
• KINETICS OF HEPATIC TRANSPORT OF 4-METHYLUMBELLIFERONE IN RATS : ANALYSIS BY MULTIPLE INDICATOR DILUTION METHOD
• KINETIC ANALYSIS OF RENAL TUBULAR TRANSPORT OF CIMETIDINE IN RATS BASED ON MULTIPLE INDICATOR DILUTION STUDIES
• Potential Cholestatic Activity of Various Therapeutic Agents Assessed by Bile Canalicular Membrane Vesicles Isolated from Rats and Humans
• The Potential for an Interaction between MRP2 (ABCC2) and Various Therapeutic Agents : Probenecid as a Candidate Inhibitor of the Biliary Excretion of Irinotecan Metabolites
• Quantitative Prediction of In Vivo Drug-drug Interactions from In Vitro Data : Effects of Active Transport of Inhibitors into the Liver
• 21C-04-3 Is It Possible to Quantitatively Predict In Vivo Drug Metabolizing Activity of Cytochrome P450 in Human Liver from In Vitro Metabolic Studies ?
• 2C-22 Quantitative prediction of in vivo metabolic activity in the liver from in vitro data based on the P450 isozyme involved.
• "S2-4 STRATEGIC PROPOSALS FOR AVOIDING TOXIC INTERACTIONS WITH DRUGS FOR CLINICAL USE DURING DEVELOPMENT AND AFTER MARKETING OF A NEW DRUG : PHARMACOKINETIC CONSIDERATION (Strategy how we can learn drug-drug interaction during the development
• KINETIC ANALYSIS OF DISPOSITION OF HUMAN EPIDERMAL GROWTH FACTOR (EGF) : ANALYSIS USING FRESHLY ISOLATED RAT HEPATOCYTE AND ANALYSIS OF RECEPTOR DYNAMICS IN ORGANS IN VIVO
• Kinetic Study on the Mechanism of Tissue Distribution of Vinblastine
• POSSIBLE MECHANISMS FOR THE CHANGES IN MICROCLIMATE-pH IN THE RAT SMALL INTESTINE AND EFFECTS OF PHENOTHIAZINE DERIVATIVES IN VIVO
• Differences in Substrate Specificity among Glutathione Conjugates (GS-X) Pump Family Members: Comparison between Multidrug Resistance-associated Protein and a Novel Transporter Expressed on a Cisplatin-resistant Cell Line (KCP-4)
• Carrier-Mediated Uptake of Grepafloxacin, a Fluoroquinolone Antibiotic, by the Isolated Rat Lung Cells
• High-Speed Data Position Detection Method Using Template Matching for Hologram Memory
• Effect of Shear Rate and Volume Fraction on Agglomerative Nature of Polymer Latex
• Influence of common variants in the pharmacokinetic genes (OATP-C, UGT1A1, and MRP2) on serum bilirubin levels in healthy subjects
• Evaluation of Methods for Prediciting Drug-drug Interactions by Monte Carlo Simulation
• Effects of Serum Albumin and Liver Cytosol on CYP2C9-and CYP3A4-mediated Drug Metabolism
• KINETIC STUDIES ON FORMATION AND BILIARY EXCRETION OF LIQUIRITIGENIN CONJUGATES IN RATS
• B-5-70 A Frequency-Offset Transmission Diversity Scheme for OFDM Mobile Communication Systems
• Complex Form Bandpass Sampling with Offset Frequency Sampling and Quadrature Component Interpolation for Modulated Signals(Software Defined Radio Technology and Its Applications)
• The role of breast cancer resistance protein, Bcrp in the transport of estrone-3-sulfate and dehydroepiandrosterone sulfate across the blood-brain barrier
• Characteristics of Nano-reactor and Phenomena during Mechanical Milling of Hematite-Graphite Mixture
• Gas Evolution during Mechanical Milling of Hematite-Graphite Mixture
• Mixing Characteristics of Newtonian Fluid by a Multi-Holed Static Mixer
• Viscosity measuring technique for gas-solid suspensions
• In vitro-in vivo Extrapolation of Transporter-mediated Clearance in the Liver and Kidney
• Characterization of the Transport of a Cationic Octapeptide, Octreotide, In Rat Bile Canalicular Membrane : Possible Involvement of P-Glycoprotein
• NUCLEAR BINDING AS A DETERMINANT OF TISSUE DISTRIBUTION OF ADRIAMYCIN, DAUNOMYCIN, ADRIAMYCINOL, DAUNORUBICINOL AND ACTINOMYCIN D
• LOCALIZATION OF lasp-2 IN CHICKEN PRIMARY CULTURED CELL(Cell Biology and Morphology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
• QUANTITATIVE EVIDENCE FOR INTERSPECIES DIFFERENCE IN TISSUE DISTRIBUTION MECHANISM OF ADRIAMYCIN
• CONTRIBUTION OF P-GLYCOPROTEIN, ASSOCIATED WITH MULTIDRUG RESISTANCE, TO BILIARY EXCRETION OF VINCRISTINE : A KINETIC ANALYSIS
• Complex Form Bandpass Sampling with Offset Frequency Sampling and Quadrature Component Interpolation for Modulated Signals
• Characterization of Arp2/3 Complex in Chicken Tissues
• Human Placental Extract Stimulates Liver Regeneration in Rats
• The Intestinal First-pass Metabolism of Substrates of CYP3A4 and P-glycoprotein-Quantitative Analysis Based on Information from the Literature
• Anti-metastatic Effect of the Sialyl Lewis-X Analog GSC-150 on the Human Colon Carcinoma Derived Cell Line KM12-HX in the Mouse
• 1-ANILINO-8-NAPHTHALENE SULFONATE BINDING SITE ON HUMAN ERYTHROCYTE MEMBRANE USING FLUORESCENCE LIFETIME AND POLARIZATION
• THE CORRELATION BETWEEN DRUG BINDING TO THE HUMAN ERYTHROCYTE AND ITS HEMOLYTIC ACTIVITY
• MULTIPLICITY OF SULFOBROMOPHTHALEIN-BINDING PROTEINS IN Y-FRACTION FROM RAT LIVER
• THE BINDING AND CONJUGATING ABILITIES OF THE Y-FRACTION FOR SULFOBROMOPHTHALEIN (BSP) IN CHRONIC CARBON TETRACHLORIDE-INTOXICATED RATS
• THE CORRELATION BETWEEN DRUG BINDING TO THE HUMAN ERYTHROCYTE MEMBRANE AND ITS HEMOLYTIC ACTIVITY, DETERMINED BY FLUORESCENT PROBE TECHNIQUES
• Expression of a putative ATP-binding cassette region, homologous to that in multidrug resistance-associated protein (MRP), is hereditarily defective in Eisai hyperbilirubinemic rats (EHBR)
• Prediction of Interindividual Variability in Pharmacokinetics for CYP3A4 Substrates in Humans
• Estimation of the Interindividual Variability of Cytochrome 2D6 Activity from Urinary Metabolic Ratios in the Literature
• Drug-drug interaction based on the inhibition on the transporter-mediated hepatic uptake (DRUG METABOLISM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
• Role of OATP transporter family in the hepatic uptake of pitavastatin (LIVER/DIGESTIVE SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
• Mechanism of Magnetic Domain Refinement on Grain-Oriented Silicon Steel by Laser Irradiation(Materials Evaluation by X-ray and Neutron Diffractions)
• X-Ray Stress Measurement of Silicon Single Crystal
• Pharmacokinetics and Mechanism of Intestinal Absorption of JBP485 in Rats
• Assessment of Chimeric Mice with Humanized Liver as a Tool for Predicting Circulating Human Metabolites
• Effect of Cetyldimethylbetaine Molecules on Agglomeration and Growth of Ice
• PHARMACOKINETIC STUDY OF 4-METHYLUMBELLIFERONE IN RATS : INFLUENCE OF DOSE ON ITS FIRST-PASS HEPATIC ELIMINATION
• ANALYSIS OF ACTIN-BINDING PROTEINS IN CHICKEN BRAIN BY 2D-PAGE(Cell Biology and Morphology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
• SEARCHING OF FILAMIN B-BINDING PROTEIN FROM CHICKEN BRAIN(Cell Biology and Morphology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
• Hydrodynamics and Heat Transfer Characteristics of Drag-Reducing Trimethylolethane Solution and Suspension by Cationic Surfactant
• Effects of Pulsating Strouhal Number on Heat Transfer around a Heated Cylinder in Pulsating Cross-Flow
• Characterization of efflux transporters in the net uptake of dehydroepiandrosterone sulfate and mitoxantrone via the blood-brain barrier in the mouse (第25回生体膜と薬物の相互作用シンポジウム--ダイナミックインターフェイスとしての生体膜 講演要旨集)
• E1 Optimization Design of Cooling Channel of Block Laminated Mold by using Genetic Algorithm(Other manufacturing-related technologies)
• Suppression of Ice Particle Growth and the Possibility of Energy Saving Latent Heat Transportation by Using Surfactant Additives
• Numerical Study on the Drawing of Polymer Optical Fibers in Steady State
• F305 INTENSIFICATION OF DISSIMILARITY BETWEEN HEAT AND MOMENTUM TRANSFER IN A DUCT FLOW WITH TEMPERATURE-CONTROLLED INJECTION/SUCTION FROM THE WALLS(Control of turbulent mixing process)
• Numerical Computations on Heat Transfer Characteristics from the Cavity Bottom in Parallel Plates Swept by Viscoelastic Fluid
• Numerical Experiments on Heat Transfer Characteristics in a Cavity Swept by Visco-Elastic Fluid
• Determination of solifenacin succinate, a novel muscarinic receptor antagonist, and its major metabolite in rat plasma by semi-micro high performance liquid chromatography
• SEARCHING OF ACTIN-BINDING PROTEINS FROM CHICKEN BRAIN WITH F-ACTIN AFFINITY COLUMN CHROMATOGRAPHY(Cell Biology and Morphology)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
• Finite arithmetie subgroups of GL_n, IV
• The rank of the group of relative units of a Galois extension II
• The rank of the group of relative units of a Galois extension
• Structure Analysis of Drag-Reducing Surfactant Rod-Like Micelles with Fluorescence Probe
• Biaxial Extensional Characteristics of Drag-Reducing Surfactant Solution
• Identification of Enzymes Responsible for the N-Oxidation of Darexaban Glucuronide, the Pharmacologically Active Metabolite of Darexaban, and the Glucuronidation of Darexaban N-Oxides in Human Liver Microsomes

もっと見る 閉じる

スポンサーリンク