THE CORRELATION BETWEEN DRUG BINDING TO THE HUMAN ERYTHROCYTE MEMBRANE AND ITS HEMOLYTIC ACTIVITY, DETERMINED BY FLUORESCENT PROBE TECHNIQUES
スポンサーリンク
概要
- 論文の詳細を見る
Cationic and anionic drugs which have hemolytic activities changed the fluorescence intensity of 1-anilino-8-naphthalene sulfonate (ANS) bound to the human erythrocyte ghost membrane. And there was a correlation between their hemolytic activities and fluorescence changes. Furthermore, ANS itself had a hemolytic activity. So it was indicated that ANS was a usefull compound to study hemolysis. The binding of ANS to the human erythrocyte ghost membrane and hemolysis by ANS were investigated with various concentration of ANS. The following results were revealed. (1) The human erythrocyte ghost membrane has two kinds of binding site for ANS. (2) The first site was already saturated by ANS before hemolysis occurred and the second site was about 50% saturated when hemolysis began. (3) The second site may play an important role in hemolysis.
- 公益社団法人日本薬学会の論文
著者
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HANANO Manabu
Faculty of Pharmaceutical Sciences, University of Tokyo
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SUGIYAMA Yuichi
Faculty of Pharmaceutical Sciences, University of Tokyo
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AWAZU SHOJI
Faculty of Pharmaceutical Science, University of Tokyo
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Hanano Manabu
Faculty Of Pharmaceutical Sciences University Of Tokyo
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Hanano M
Department Of Pharmaceutics College Of Pharmacy Nihon University
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Hanano Manabu
Faculty Of Pharmaceutical Science University Of Tokyo
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Sugiyama Yuichi
Faculty Of Pharmaceutical Sciences University Of Tokyo
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Awazu Shoji
Department Of Biopharmaceutics Tokyo College Of Pharmacy:department Of Pharmaceutics Research Center
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Awazu Shoji
Faculty Of Pharmaceutical Sciences University Of Tokyo:(present Address)tokyo College Of Pharmacy
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Awazu Shoji
Faculty Of Pharmaceutical Science University Of Tokyo:(present Address)tokyo College Of Pharmacy
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HORIE Toshiharu
Faculty of Pharmaceutical Sciences, Chiba University.
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Awazu S
Department Of Biopharmaceutics Tokyo College Of Pharmacy:department Of Pharmaceutics Research Center
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澤山 茂
東京農大 栄養
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Horie Toshiharu
Faculty Of Pharmaceutical Sciences University Of Tokyo:(present Address)tokyo College Of Pharmacy
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Horie Toshiharu
Faculty Of Pharmaceutical Sciences Chiba University.
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Sugiyama Yuichi
Faculty Of Pharmaceutical Sciences The University Of Tokyo
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