Effect of Serum on Dose-and Temperature-Dependent Hepatic Uptake of Multilamellar Vesicles (MLV)
スポンサーリンク
概要
- 論文の詳細を見る
Effects of the addition of serum to the perfusate on hepatic uptake of multilamellar vesicles (MLV) were examined in recirculating perfused rat liver. MLV was labelled with both membrane lipid marker ([^<14>C] cholesteryl oleate) and aqueous phase marker ([^3H] inulin or 5 (6)-carboxyfluorescein (CF)). The uptake rates of [^<14>C] cholesteryl oleate and CF at 37℃ coincided well, indicating both markers to be taken up as MLV. Inulin was released from MLV at 37℃ but its uptake rate tended to approach that of [^<14>C] cholesteryl oleate at 4℃ or at high MLV dose. Some factor in serum promoted MLV uptake at 37℃, but its effect was inhibited at 4℃. The promoting effect was indicated to be possibly due to activation of adsorption of MLV to the hepatic Kupffer cell surface and/or that of phagocytosis by the cells. The saturation of MLV uptake was observed with increase in MLV dose, suggesting the saturation of MLV adsorption to the hepatic cell or the consumption of serum factor which promotes MLV uptake.
- 公益社団法人日本薬学会の論文
著者
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Kiwada Hiroshi
Faculty Of Pharmaceutical Science University Of Tokyo:(present Address)faculty Of Pharmaceutical Sci
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Kato Yuriko
Faculty Of Pharmaceutical Sciences Science University Of Tokyo:department Of Biopharmaceutics Tokyo
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HAYASHI Masahiro
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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AWAZU SHOJI
Faculty of Pharmaceutical Science, University of Tokyo
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Awazu S
Tokyo Coll. Pharmacy Tokyo Jpn
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Awazu Shoji
Faculty Of Pharmaceutical Science University Of Tokyo:(present Address)tokyo College Of Pharmacy
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Awazu Shoji
Department Of Biopharmaceutics Tokyo College Of Pharmacy
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Kiwada H
Univ. Tokushima Tokushima Jpn
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Kiwada Hiroshi
Faculty Of Pharmaceutical Science The University Of Tokushima
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TAHARA Koichiro
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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Tahara Koichiro
Department Of Biopharmaceutics Tokyo College Of Pharmacy:department Of Pharmaceutics Research Center
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Hayashi Masahiro
Faculty Of Agriculture Miyazaki University
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