Paracellular and Transcellular Permeabilities of Fosfomycin across Small Intestinal Membrane of Rat and Rabbit by Voltage-Clamp Method
スポンサーリンク
概要
- 論文の詳細を見る
The permeability of fosfomycin (FOM), which is a low molecular weight and water-soluble antibiotic, across rat and rabbit jejunal membrane was investigated on a paracellular route and a transcellular route separated by voltage-clamp method. It was determined that FOM permeates through these two routes in both animals. Under a physiologically normal condition, the transmucosal electrical potential difference (about 2 mV), the contribution of the transcellular route to FOM membrane permeability was greater than that of the paracellular route. The transcellular permeability was significantly reduced in the presence of inorganic phosphate. The inhibitory effects of the inorganic phosphate coincided with our reports on FOM uptake by rat jejunal brush-border membrane vesicles in vitro and on FOM absorption by rat jejunal single-pass perfusion in situ.
- 公益社団法人日本薬学会の論文
著者
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AWAZU Shoji
東京薬科大学薬学部 薬物動態制御学教室
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Awazu S
Tokyo Coll. Pharmacy Tokyo Jpn
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Awazu Shoji
Department Of Biopharmaceutics Tokyo College Of Pharmacy:department Of Pharmaceutics Research Center
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Awazu Shoji
Department Of Biopharmaceutics Tokyo College Of Pharmacy
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Awazu Shoji
Deparment Of Biopharmaceutics Tokyo College Of Pharmacy
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ISHIZAWA Takayuki
Pharmaceutical Research Laboratories, Meiji Seika Kaisha, Ltd.
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HAYASHI Masahiro
Pharmaceutical Research Laboratories, Meiji Seika Kaisha, Ltd.
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AWAZU Shoji
Pharmaceutical Research Laboratories, Meiji Seika Kaisha, Ltd.
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Awazu S
Department Of Biopharmaceutics Tokyo College Of Pharmacy:department Of Pharmaceutics Research Center
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Ishizawa Takayuki
Meiji Seika Kaisha Ltd. Pharmaceutical Research Center:department Of Surgery Kawasaki City Ida Hospi
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Awazu S
Department Of Biopharmaceutics School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Awazu S
Department Of Biopharmaceutics Tokyo College Of Pharmacy
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