Pulmonary Absorption of Recombinant Human Granulocyte Colony-Stimulating Factor (rhG-CSF) after Intratracheal Administration to Rats
スポンサーリンク
概要
- 論文の詳細を見る
Pulmonary absorption of recombinant human granulocyte colony-stimulating factor (rhG-CSF) was examined in the rat. The relative bioavailabilities of rhG-CSF after intratracheal administration to intravenous and subcutaneous means were 11.6% and 27.4%, respectively, which were evaluated from the ratio of area under the curve (AUC) of the plasma rhG-CSF concentration versus time for 8h. The pharmacological availability after the pulmonary absorption was determined from the AUC for the increase ratio in total blood leukocyte numbers versus time curve. The avaiability was equal to or more than the availabilities after intravenous or subcutaneous administration. Comparison of the two different parenteral administration routes for rhG-CSF, intratracheal and intranasal showed the pharmacological availability after the intratracheal administration to be superior. The pulmonary absorption of rhG-CSF is thus an effective parenteral route of administration.
- 公益社団法人日本薬学会の論文
- 1996-02-15
著者
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HAYASHI Masahiro
Department of Dermatology, Yamagata University School of Medicine
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MACHIDA Minoru
Formulation Technology, Laboratory, Chugai Pharmaceutical Co., Ltd.
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AWAZU Shoji
Department of Biopharmaceutics, School of Pharmacy, Tokyo University of Pharmacy and Life Science
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Machida Minoru
Formulation Technology Laboratory Chugai Pharmaceutical Co. Ltd.
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AWAZU Shoji
東京薬科大学薬学部 薬物動態制御学教室
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Awazu S
Tokyo Coll. Pharmacy Tokyo Jpn
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Awazu Shoji
Department Of Biopharmaceutics Tokyo College Of Pharmacy:department Of Pharmaceutics Research Center
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Awazu Shoji
Deparment Of Biopharmaceutics Tokyo College Of Pharmacy
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Hayashi Masahiro
Department Of Biological Production And Enviromental Science Faculty Of Agriculture The University O
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Awazu S
Department Of Biopharmaceutics School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Hayashi Masahiro
Department of Absorption and Pharmacokinetics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
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