Occurrence of 5'-Deoxyadenosylcobalamin and Its Physiological Function as the Coenzyme of Methylmalonyl-CoA Mutase in a Marine Eukaryotic Microorganism, Schizochytrium limacinum SR21
スポンサーリンク
概要
- 論文の詳細を見る
A marine eukaryotic microorganism, Schizochytrium limacinum SR21, had the ability to absorb and accumulate exogenous cobalamin, which was converted to the cobalamin coenzymes 5'-deoxyadenosylcobalamin (20.1%) and methylcobalamin (29.6%). A considerably high activity (about 38mU/mg protein) of 5'-deoxyadenosylcobalamin-dependent methylmalonyl-CoA mutase (EC 5.4.99.2) involved in amino acid and odd-chain fatty acid metabolism was found in the cell homogenate of S. limacinum SR21. The enzyme was purified to homogeneity and characterized.
- 日本ビタミン学会の論文
著者
-
Yukino Tsugiyo
Department Of Nutritional Sciences Nayoro City University
-
NAKANO Yoshihisa
Department of Applied Biological Chemistry, Graduate School of Life and Environmental Sciences, Osak
-
Nakano Y
Dep. Of Applied Biological Chemistry Graduate School Of Life And Environmental Sciences Osaka Prefec
-
HAYASHI Masahiro
Department of Dermatology, Yamagata University School of Medicine
-
MIYAMOTO Emi
Department of Pharmacy, Municipal Ikeda Hospital
-
NAKANO Yoshihisa
Graduate School of Life and Environmental Sciences of Osaka Prefecture University
-
TANIOKA Yuri
Department of Applied Biological Chemistry, Osaka Prefecture University
-
WATANABE Fumio
School of Agricultural, Biological and Environmental Sciences, Faculty of Agriculture, Tottori Unive
-
Nakano Yoshihisa
Graduate School Of Life And Environmental Science Osaka Prefecture University
-
Nakano Yoshihisa
Department Of Agriculture University Of Osaka Prefecture
-
Nakano Yoshihisa
Nutrition Laboratory College Of Agriculture
-
Tamura Yoshiyuki
The Second Department Of Internal Medicine School Of Medicine The University Of Tokushima
-
Yoshiyuki Tamura
Laboratory Of Nutrition And Food Science Hagoromo University Of International Studies
-
Tamura Yoshiyuki
Second Depertment Of Internal Medicine School Of Medicine The University Of Tokushima
-
Tanioka Yuri
Department Of Nutrition Junior College Of Tokyo University Of Agriculture
-
Miyamoto Emi
Department Of Health And Nutrition Nagasaki International University
-
Tokunaga Yoko
Division Of Applied Biological Chemistry Department Of Bioscience And Biotechnology Faculty Of Agric
-
Watanabe Fumio
School Of Agricultural Biological And Environmental Sciences Faculty Of Agriculture Tottori Universi
-
Watanabe F
Faculty Of Regional Environmental Science Tokyo University Of Agriculture
-
Hayashi Masahiro
Department Of Biological Production And Environmental Science Faculty Of Agriculture University Of M
-
Hayashi Masahiro
Department Of Biological Production And Enviromental Science Faculty Of Agriculture The University O
-
Nakano Yoshihisa
Department Of Agricultural Chemistry
-
Yukino Tsugiyo
Department Of Nutritional Sciences Faculty Of Health And Welfare Science Nayoro City University
-
Watanabe Fumio
Department Of Oral And Maxillofacial Sciences Gifu University School Of Medicine
-
Yukino Tsugio
Department of Nutritional Sciences, Nayoro City University
-
Hayashi Masahiro
Department of Absorption and Pharmacokinetics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
関連論文
- Hydrolyzable Tannins as Antioxidants in the Leaf Extract of Eucalyptus globulus Possessing Tyrosinase and Hyaluronidase Inhibitory Activities
- Digestion and Absorption of Siraitia grosvenori Triterpenoids in the Rat
- Case of hypereosinophilic syndrome with cutaneous necrotizing vasculitis
- Characteristics of vulvar squamous cell carcinoma in Japanese women
- Purification and Characterization of Corrinoid-Compounds from the Dried Powder of an Edible Cyanobacterium, Nostoc commune (Ishikurage)
- Effect of Tea Catechins on Cellular Lipid Peroxidation and Cytotoxicity in HepG2 Cells(Food & Nutrition Science)
- Dual radionuclide single-photon emission computed tomography in the prediction of further ischemic risk after acute myocardial infarction
- Effect of Aminated Gelatin on the Nasal Absorption of Insulin in Rats(Biopharmacy)
- Genetic analysis of cutaneous squamous cell carcinomas arising from different areas
- Evaluation of Absorbability of Poorly Water-Soluble Drugs : Validity of the Use of Additives
- HISTOPATHOLOGICAL STUDY OF THE EFFECTS OF A SINGLE INTRATRACHEAL INSTILLATION OF SURFACE ACTIVE AGENTS ON LUNG IN RATS
- RELATIONSHIP OF REHABILITATION INTERFARING FACTORS TO PROLONGED PROGNOSIS IN PATIENTS WITH MYOCARDIAL INFARCTION : Exercise Test (I) : FREE COMMUNICATIONS (V) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Resveratrol Down-Regulates the Androgen Receptor at the Post-Translational Level in Prostate Cancer Cells
- IMPROVEMENT OF POORLY ABSORBABLE DRUG BY INTESTINAL GLUCOSE TRANSPORT SYSTEM
- 移植手術成功には抗酸化物質の併用が必要!
- Effectiveness of Pirotiodecane, Absorption Enhancer, on Nasal Absorption in Rabbits
- Effect of Administration of Adlay Leaves on 2,4,6-trinitro-1-chlorobenzene-induced Chronic Dermatitis in Mice
- Requirement of Oxygen for Dark Hydrogen Evolution by a Green Alga, Chlamydomonas reinhardtii
- Absence of BAT-26 instability in gastric intestinal metaplasia
- Occurrence of Vitamin B_ in Green, Blue, Red, and Black Tea Leaves
- Characterization of a Vitamin B_ Compound in the Edible Purple Laver, Porphyra yezoensis
- Microsatellite instability in esophageal squamous cell carcinoma is not associated with hMLH1 promoter hypermethylation
- Incorporation of Exogenous Docosahexaenoic Acid into Triacylglycerols and Polar Lipids of Chlorella vulgaris
- A Technique to Enrich α-tocopherol in Clilorella and Marine Rotifers
- Uptake and Accumulation of Exogenous Docosahexaenoic Acid by Chlorella
- Low Sucrase Activity in the Small Intestine of a Senescence-accelerated Strain of Mouse, SAMP1
- CLINICAL SIGNIFICANCE OF LEFT VENTRICULAR REGIONAL WALL MOTION EVALUATED BY MRI IN PATIENTS WITH OLD MYOCARDIAL INFARCTION : CT, MRI : 53 Annual Scientific Meeting, Japanese Circulation Society
- Occurrence of 5'-Deoxyadenosylcobalamin and Its Physiological Function as the Coenzyme of Methylmalonyl-CoA Mutase in a Marine Eukaryotic Microorganism, Schizochytrium limacinum SR21
- Effect of Vitamin B12-Enriched Thraustochytrids on the Population Growth of Rotifers
- Occurrence of Pseudovitamin B_ and Its Possible Function as the Cofactor of Cobalamin-Dependent Methionine Synthase in a Cyanobacterium Synechocystis sp. PCC6803
- Characterization of a Corrinoid Compound in the Edible (Blue-Green) Alga, Suizenji-nori
- Abnormal Increase in the Expression Level of Proliferating Cell Nuclear Antigen (PCNA) in the Liver and Hepatic Injury in Rats with Dietary Cobalamin Deficiency
- Occurrence of Coenzyme Forms of Vitamin B_ in a Cultured Purple Laver (Porphyla yezoensis)(Food & Nutrition Sience)
- Nitric Oxide Synthase Induction, cGMP Elevation, and Biopterin Synthesis in Vascular Smooth Muscle Cells Stimulated with Interleukin-1β in Hypoxia
- Purification and Characterization of Methylmalonyl-CoA Mutase from a Methanol-Utilizing Bacterium, Methylobacterium extorquens NR-1
- Uptake and physiological function of vitamin B_ in a photosynthetic unicellular coccolithophorid alga, Pleurochrysis carterae(Microbiology & Fermentation Technology)
- Expression of a Gene Encoding Chitinase(pCA 8 ORF)from Aeromonas sp.No.10S-24 in Escherichia coli and Enzyme Characterization
- Increases in Gastric Histidine Decarboxylase Activity and Plasma Gastrin Level in Streptozotocin-induced Type 1 Diabetic Rats
- Purification and Characterization of ADP-Ribosyl Cyclase from Euglena gracilis
- Suppression by Water Extracts of Sophora Plants of Sucrose-induced Hyperglycemia in Rats and Inhibition of Intestinal Disaccharidases In Vitro
- α2-Adrenoceptor-Mediated Antisecretory Effect of Hypoxia in Conscious Rats
- Inhibitive Effects of Alkyl Gallates on Hyaluronidase and Collagenase
- Effects of Carnosine and Anserine on the Destruction of Vitamin B_ with Vitamin C in the Presence of Copper
- Occurrence of Cobalamin Coenzymes in the Photosynthetic Green Alga, Chlorella vulgaris
- Clarification of the Mechanism of Structural Change Induced by Reoxygenation following the Induction of Lipid Peroxidation in Caco-2 Cell Monolayers
- PARACELLULAR CHANNEL CHARACTERIZED BY NON-ELECTROLYTE PERMEATION THROUGH THE COLONIC MEMBRANE OF THE RAT
- MECHANISMS FOR THE ENHANCEMENT OF INTESTINAL MEMBRANE PERMEABILITY BY ABSORPTION PROMOTERS
- Effects of Cold Shock Treatment on Total Lipid Content and Fatty Acid Composition of Aurantiochytrium limacinum strain mh0186
- A Novel Phosphatidylcholine Which Contains Pentadecanoic Acid at sn-1 and Docosahexaenoic Acid at sn-2 in Schizochytrium sp. F26-b
- 肝臓および腎臓における P-glycoprotein に対する小腸虚血再灌流の影響
- Assessment of Ileal Epithelial P-Glycoprotein Dysfunction Induced by Ischemia/Reperfusion using in vivo Animal Model
- The Novel Formulation Design of Self-emulsifying Drug Delivery Systems (SEDDS) Type O/W Microemulsion III : The Permeation Mechanism of a Poorly Water Soluble Drug Entrapped O/W Microemulsion in Rat Isolated Intestinal Membrane by the Ussing Chamber Metho
- ALTERATION IN RAT LIVER MICROSOMAL MEMBRANES INDUCED BY ACETAMINOPHEN
- HETEROGENEOUS DISTRIBUTION OF THE CONJUGATION ACTIVITY OF ACETAMINOPHEN AND p-NITROPHENOL IN ISOLATED RAT LIVER CELLS
- MULTIPLE FORMS OF ARYL SULFOTRANSFERASE FOR ACETAMINOPHEN SULFATE CONJUGATION IN RAT LIVER CYTOSOL
- HETEROGENEOUS DISTRIBUTION OF CONJUGATION ACTIVITIES OF HARMOL IN ISOLATED RAT LIVER CELLS
- An autopsied case of Creutzfeldt-Jakob disease with the lateral geniculate body lesion showing antagonizing correlation between periodic synchronous discharges and photically induced giant evoked responses
- Neuropathological comparative study of two patients with Machado-Joseph disease(MJD)
- Linear immunoglobulin A bullous dermatosis associated with herpes simplex virus infection and Kawasaki disease
- Purification and Characterization of Serine Hydroxymethyltransferase from Mitochondria of Euglena gracilis z
- Effects of D-Amino Acids on Cytosolic Serine Hydroxymethyltransferase from Euglena gracilis z
- Purification and Characterization of Cytosolic Serine Hydroxymethyltransferase from Euglena gracilis z(Biological Chemistry)
- P440 THREE DIMENSIONAL RECONSTRUCTED MAGNTIC RESONANCE IMAGING IN ADULT CONGENTIAL HEART DISEASE : IMPROVEMENT OF MODELING AND SURFACE RENDERING
- Subcellular Localization and Some Properties of NADP^+ -Linked Malic Enzymes in Euglena
- Rare case of biphasic tumor of the breast with prominent CD34-positive spindle cells
- Survey of Enhanced, Thermally Stable, and Soluble Second-Order Nonlinear Optical Azo Chromophores
- 酒石酸の新たな役割 : P-glycoprotein 機能修飾
- Regional Difference in P-glycoprotein Function in Rat Intestine
- Optimization of Culture Conditions for Growth and Docosahexaenoic Acid Production by a Marine Thraustochytrid, Aurantiochytrium limacinum mh0186
- Detection of HPV-DNA, p53 alterations, and methylation in penile squamous cell carcinoma in Japanese men
- Mutation analyses of patients with dyschromatosis symmetrica hereditaria : Five novel mutations of the ADAR1 gene
- Production and Composition of Euglena Wax Esters at High Temperature(Microbiology & Fermentation Industry)
- ACTION MECHANISM OF PERMEATION ENHANCERS IN PARACELLULAR PATHWAY
- INTESTINAL ABSORPTION OF MACROMOLECULAR COMPOUNDS-IS ITS IMPROVEMENT POSSIBLE?
- ARYL SULFOTRANSFERASE IN RAT LIVER : MULTIPLICITY AND SUBSTRATE SPECIFICITY
- ALBUMIN-MEDIATED UPTAKE MECHANISM OF DRUG BY ISOLATED HEPATOCYTES
- CHARACTERIZATION OF THE INTERACTION OF ALBUMIN WITH ISOLATED RAT LIVER CELLS TO REVEAL THE MECHANISM OF ALBUMIN-MEDIATED HEPATIC TRANSPORT
- p-NITROPHENOL SULFATION IN RAT LIVER CYTOSOL : MULTIPLE FORMS AND SUBSTRATE INHIBITION OF ARYL SULFOTRANSFERASE
- CORRELATION OF DRUG CONJUGATIVE METABOLISM RATES BETWEEN IN VIVO AND IN VITRO : GLUCURONIDATION AND SULFATION OF p-NITROPHENOL AS A MODEL COMPOUND IN RAT
- CORRELATION BETWEEN IN VIVO AND IN VITRO DRUG CONJUGATIVE METABOLISM RATE : p-NITROPHENOL AS A MODEL COMPOUND
- The Effects of Absorption Enhancers on the Pulmonary Absorption of Recombinant Human Granulocyte Colony-Stimulating Factor (rhG-CSF) in Rats
- Pulmonary Absorption of Recombinant Human Granulocyte Colony-Stimulating Factor (rhG-CSF) after Intratracheal Administration to Rats
- Hepatic Uptake of Lipid-Soluble Drugs from Fat Emulsion
- ADM-INDUCED LIPID PEROXIDATION IN RAT LIVER AND HEART
- PROTECTION OF RAT SMALL INTESTINE BY VITAMIN A FROM METHOTREXATE-INDUCED DAMAGE : STUDY ON THE NUTRIENT ABSORPTION IN THE SMALL INTESTINE
- Effect of Carrier-Mediated Transport System on Intestinal Fosfomycin Absorption in Situ and in Vivo
- PROTECTION OF RAT SMALL INTESTINE BY VITAMIN A FROM ITS DAMAGE INDUCED BY METHOTREXATE
- SOLVENT DRAG EFFECT IN DRUG INTESTINAL ABSORPTION : STUDIES ON DRUG AND D_2O ABSORPTION CLEARANCES
- Maternal vitamin B_ deficiency affects spermatogenesis at the embryonic and immature stages in rats
- The effects of dietary vitamin B_ deficiency on sperm maturation in developing and growing male rats
- Improvement of Drug Release Rate from Carbopol 934P Formulation
- A Yeast Bioassay for Androgenic and Anti-Androgenic Compounds Based on the NH_ and COOH-Terminal Interaction of Androgen Receptor
- Immunohistochemical study of neuronal intranuclear and cytoplasmic inclusions in Machado-Joseph disease
- Inhibitive Effects of Alkyl Gallates on Hyaluronidase and Collagenase
- Mitochondrial Alcohol Dehydrogenase from Ethanol-Grown Euglena gracilis
- Effects of Diets on the Concentration of Fructose-2, 6-bisphosphate in Rat Liver
- Construction of a Dominant Negative Form of Human Hypoxia-Inducible Factor-2α
- Effect of Vitamin B12-Enriched Thraustochytrids on the Population Growth of Rotifers
- Dermoscopic features in a case of dyschromatosis symmetrica hereditaria
- Effects of Epigallocatechin 3-O-Gallate on Cellular Antioxidative System in HepG2 Cells