ARYL SULFOTRANSFERASE IN RAT LIVER : MULTIPLICITY AND SUBSTRATE SPECIFICITY

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概要

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• Rat liver aryl sulfotransferase was purified by chromatography on diethylaminoethyl-cellulose or chromatofocusing and three fractions, referred to by Sekura and Jakoby as I, II and IV, were obtained in the order of their elution, each containing sulfation activity. p-Nitrophenol (PNP) at mM order and β-naphthol were substrates common to all three fractions, but PNP at μM order and tyramine were substrates only for IV. IV corresponded to the enzyme designated M by Rein et al. and was active with monoamine, as predicted from our previous results with rat liver cytosol. However, the effectiveness of IV in bringing about the sulfation of PNP at mM order was not evident from our previous results. The characteristics of aryl sulfotransferase multiplicity on the basis of thermostability of sulfation activity could not be determined since essentially the characteristics were the same for all three purified fractions. The multiplicity of aryl sulfotransferase purified from rat liver was different from that of human platelets, indicating possible species and/or tissue differences in this enzyme.

• 公益社団法人日本薬学会の論文

著者

• Nakamura J

  Tokyo Coll. Pharmacy Tokyo Jpn

• HAYASHI Masahiro

  Department of Dermatology, Yamagata University School of Medicine

• NAKAMURA Junko

  Department of Laboratory, Saiseikai Nakatsu Hospital

• AWAZU Shoji

  Department of Biopharmaceutics, School of Pharmacy, Tokyo University of Pharmacy and Life Science

• MIZUMA Takashi

  Department of Biopharmaceutics, Tokyo College of Pharmacy

• HORIE Toshiharu

  Departments of Biopharmaceutice, Graduate School of Pharmaceutical Sciences, Chiba University

• AWAZU Shoji

  東京薬科大学薬学部 薬物動態制御学教室

• Mizuma Takashi

  Department Of Biopharmaceutics Tokyo College Of Pharmacy

• Mizuma Takashi

  Department Of Biopharmaceutics And Drug Rational Research Center School Of Pharmacy Tokyo University

• Awazu Shoji

  Deparment Of Biopharmaceutics Tokyo College Of Pharmacy

• Awazu S

  Department Of Biopharmaceutics Tokyo College Of Pharmacy:department Of Pharmaceutics Research Center

• Hayashi Masahiro

  Department Of Biological Production And Enviromental Science Faculty Of Agriculture The University O

• Nakamura Junko

  Department Of Biopharmaceutics Tokyo College Of Pharmacy

• 澤山 茂

  東京農大 栄養

• Horie Toshiharu

  Department Of Biopharmaceutics Graduate School Of Pharmaceutical Sciences Chiba University

• Nakamura Junko

  Department Of Biology Faculty Of Science Niigata University

• Awazu S

  Department Of Biopharmaceutics School Of Pharmacy Tokyo University Of Pharmacy And Life Science

• Mizuma Takashi

  Department of Applied Chemistry, Faculty of Engineering, Osaka University

• Hayashi Masahiro

  Department of Absorption and Pharmacokinetics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences

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