IMMUNOLOGICAL CONTROL OF DRUG ABSORPTION FROM THE GASTROINTESTINAL TRACT : EFFECT OF LOCAL ANAPHYLAXIS ON THE INTESTINAL ABSORPTION OF LOW MOLECULAR WEIGHT DRUGS IN THE RAT
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概要
- 論文の詳細を見る
Intestinal absorption of various drugs was examined by means of in situ recirculation technique during local anaphylaxis. The antibody was determined by passive cutaneous anaphylaxis technique in rats immunized once or three times. The optimal condition of local anaphylaxis was determined by the leakage of Evans Blue. The most significant increase in leaks of the dye was observed by the intraluminal challenge with 400 mg of ovalbumin for 10 min in ovalbumin-immunized rats, and this condition was chosen as the optimal condition of local anaphylaxis. Under this condition, intestinal absorption of caffeine, phenylbutazone, and bromthymol blue (BTB) significantly decreased in ovalbumin-immunized rats compared with the control, whereas no significant effect was noted in the intestinal absorption of salicylic acid, quinine, pralidoxime iodide (2-PAM), tetracycline, and phenol red. In normal rats, no significant decrease was obtained in the intestinal absorption of caffeine, phenylbutazone, and BTB. On the other hand, the decreased absorption of BTB was not found in ovalbuminimmunized rats by the intraluminal challenge with bovine γ-globulin. Furthermore, there was no significant change in the decreased absorption of BTB between rats immunized once and three times. The most effective condition for decreased BTB absorption was observed by the intraluminal challenge with 200 mg of ovalbumin for 10 min in ovalbuminimmnized rats, which almost correlated with the data of Evans Blue leakage. From these observations, it appears that the mucosal immune responses affect the intestinal absorption of low molecular weight drugs.
- 公益社団法人日本薬学会の論文
著者
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Hashida Mitsuru
Department Of Basic Pharmaceutics Faculty Of Pharmaceutical Sciences Kyoto University
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Nakamura J
Faculty Of Pharmaceutical Sciences Nagasaki University
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Nakamura Junzo
長崎大学 薬
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Nakamura Junzo
Faculty Of Pharmaceutical Sciences Nagasaki University
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Hashida M
Departments Of Drug Delivery Research Graduate School Of Pharmaceutical Sciences Kyoto University
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Sezaki H
Faculty Of Pharmaceutical Sciences Setsunan University
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SEZAKI Hitoshi
Faculty of Pharmaceutical Sciences, Kyoto University
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Nakamura J
Tokyo Coll. Pharmacy Tokyo Jpn
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Sezaki H
Setsunan Univ. Osaka Jpn
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Sezaki Hitoshi
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kyoto University
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Sezaki Hitoshi
Faculty Of Pharmaceutical Sciences Kyoto University
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Sezaki Hitoshi
Departments Of Pharmacy Faculty Of Pharmaceutical Sciences Setsunan University
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Sezaki Hitoshi
Faculty Of Pharmaceutical Sciences Setsunan University
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Hashida M
Department Of Drug Delivery Research Graduate School Of Pharmaceutical Sciences Kyoto University
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HAMAURA TAKESHI
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kyoto University
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Hamaura T
Kyoto Univ.
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HAMAURA TAKESHI
Faculty of Pharmaceutical Sciences, Kyoto University
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Sasaki Hitoshi
Faculty Of Pharmaceutical Sciences Kyoto University
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Hamaura Takeshi
Faculty Of Pharmaceutical Sciences Kyoto University
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Yamamoto A
Department Of Biopharmaceutics Kyoto Pharmaceutical University
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