Lipid Carrier Systems for Targeted Drug and Gene Delivery
スポンサーリンク
概要
- 論文の詳細を見る
For effective chemotherapy, it is necessary to deliver therapeutic agents selectively to their target sites, since most drugs are associated with both beneficial effects and side effects. The use of lipid dispersion carrier systems, such as lipid emulsions and liposomes, as carriers of lipophilic drugs has attracted particular interest. A drug delivery system can be defined as a methodology for manipulating drug distribution in the body. Since drug distribution depends on the carrier, administration route, particle size of the carrier, lipid composition of the carrier, electric charge of the carrier and ligand density of the targeting carrier, these factors must be optimized. Recently, the lipid carrier system has also been applied to gene delivery systems for gene therapy. However, in both drug and gene medicine cases, a lack of cell-selectivity limits the wide application of this kind of drug and/or gene therapy. Therefore, lipid carrier systems for targeted drug and gene delivery must be developed for the rational therapy. In this review, we shall focus on the progress of research into lipid carrier systems for drug and gene delivery following systemic or local injection.
- 社団法人日本薬学会の論文
- 2005-08-01
著者
-
Yamashita Fumiyoshi
第一三共 葛西研究開発センター
-
Yamashita Fumiyoshi
Department Of Drug Delivery Research Graduate School Of Pharmaceutical Sciences Kyoto University
-
Yamashita Fumiyoshi
Departments Of Drug Delivery Research Graduate School Of Pharmaceutical Sciences Kyoto University
-
Yamashita Fumiyoshi
Graduate School Of Pharmaceutical Sciences Kyoto University
-
Hashida Mitsuru
第一三共 葛西研究開発センター
-
Hashida Mitsuru
Department Of Basic Pharmaceutics Faculty Of Pharmaceutical Sciences Kyoto University
-
Hashida Mitsuru
京都大学 薬学研究科病態情報薬学
-
Sugahara Kazuyuki
長崎大学 医歯薬学総合研究科臨床検査医学講座
-
Kawakami Shigeru
京都大学 薬学研究科
-
Kawakami Shigeru
Dep. Of Drug Delivery Res. Graduate School Of Pharmaceutical Sciences Kyoto Univ.
-
Hashida Mitsuru
Dep. Of Drug Delivery Res. Graduate School Of Pharmaceutical Sciences Kyoto Univ. 46-29 Yoshidashimo
-
Hashida Mitsuru
Inst. Of Integrated Cell-material Sciences (icems) Kyoto Univ.
-
Yamashita Fumiyoshi
Dep. Of Drug Delivery Res. Graduate School Of Pharmaceutical Sciences Kyoto Univ. 46-29 Yoshidashimo
-
Kohno Shigeru
長崎大学医学部歯学部附属病院 薬剤部
-
Sugahara Yazuyuki
長崎大学 医歯薬学総合研究科臨床検査医学講座
-
Sugahara Yazuyuki
Dep. Of Lab. Medicine Nagasaki Univ. Graduate School Of Biomedical Sciences Nagasaki Univ. Hospital
-
Kawakami Shigeru
Department Of Drug Delivery Research Graduate School Of Pharmaceutical Sciences Kyoto University
-
Kohno Shigeru
長崎大学 第二内科
-
Kanazawa Shigeo
公立みつぎ総合病院
-
Hara Shintaro
長崎大学 医学部第二内科
-
Sakanaka Koji
参天製薬奈良研究開発センター
-
Hashida M
Department Of Drug Delivery Research Graduate School Of Pharmaceutical Sciences Kyoto University
-
Hashida Mitsuru
Graduate School Of Pharmaceutical Sciences Kyoto University
-
YAMASHITA Fumiyoshi
京大院薬
-
HASHIDA Mitsuru
京大院薬
-
Kashiwagi Satsuki
School Of Pharmaceutical Sciences Nagasaki University
-
Sakanaka Koji
Department Of Hospital Pharmacy Nagasaki University Hospital Of Medicine And Dentistry:santen Pharma
-
Yamashita Fumiyoshi
Dep. Of Drug Delivery Res. Graduate School Of Pharmaceutical Sciences Kyoto Univ.
関連論文
- 非ウイルス性感染症 マイコプラズマ・ニューモニエ (広範囲 血液・尿化学検査 免疫学的検査(第7版・3)その数値をどう読むか) -- (免疫学的検査 感染症関連検査(抗原および抗体を含む))
- 呼吸器感染症に対する levofloxacin 500mg 1日1回投与の臨床効果
- 急性気管支炎および慢性呼吸器病変の二次感染に対する azithromycin 単回投与製剤の多施設共同非盲験非対照試験
- 経肺デリバリーのニーズと臨床応用 : 呼吸器感染症を中心に
- 成人院内肺炎に対するセフェム系抗菌薬 ceftazidime の1日4回投与による血中濃度および臨床効果の検討
- 市中肺炎に対するスイッチ治療の有用性
- P-126 長崎大学医学部附属病院における 10 年間の注射用抗生物質の使用状況
- 肺炎ガイドラインの国際比較 (特集 肺炎2010)
- 下気道由来検体から分離された β-lactamase non-producing ampicillin resistant Haemophilus influenzae (BLNAR) の分離頻度と薬剤感受性
- Antimicrobial susceptibility of respiratory tract pathogens in Japan during PROTEKT years 1-3 (1999-2002)
- P-081 軽症の糖尿病患者に発症したAspergillus udagawaeによる気管支アスペルギルス症の1例(深在性真菌症,ポスター討論,一般演題,医真菌学のコペルニクス的転回を目指して)
- P-031 当科におけるAspergillus fumigatus臨床分離株の薬剤感受性に関する検討(深在性真菌症,ポスター討論,一般演題,医真菌学のコペルニクス的転回を目指して)
- P-026(SS4-1) PravastatinはCandida albicansのFarnesol産生を抑制し、播種性カンジダ症モデルマウスの生存率を改善する(診断・治療法,セレクテッドシンポジウム,ポスター討論,一般演題,医真菌学のコペルニクス的転回を目指して)
- 結核菌群遺伝子増幅検査におけるコバスTaqMan MTBの有用性
- Southern blot Hybridization (SBH) 法の精度管理と迅速化
- P-341 MRSA 感染症におけるテイコプラニン投与法の実際 : 除菌効果および副作用との関係
- Biapenemに対する各種臨床分離菌株の薬剤感受性の年次推移について
- 臨床細菌学的立場から - 新しい耐性菌も含めて -
- Lung fibrosis 10 years after cessation of bleomycin therapy.
- PJ-675 Abdominal Visceral Fat is Associated with not only Arteriosclerosis, but also Coronary Artery Spasm(Diabetes / Obesity / Metabolic syndrome(13)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Primary High-Grade Myofibroblastic Sarcoma Arising From the Pericardium
- PJ-330 Evaluation of Left Ventricular Function Using Tei-index in Obstructive Sleep Apnea Syndrome and Effect of Nasal Continuous Positive Airway Pressure(Cardiac function, basic/clinical-4 (M) PJ56,Poster Session (Japanese),The 70th Anniversary Annual Sc
- PE-422 IQGAP1 Regulates Reactive Oxygen Species-dependent Endothelial Cell Migration through Interacting with NAD (P) H Oxidase Subunit (Nox2)(Molecular biology, vascular-2 (H) PE71,Poster Session (English),The 70th Anniversary Annual Scientific Meeting o
- Chest Pain and ST Segment Depression Caused by Expansion of Gastric Tube Used for Esophageal Reconstruction
- A Probable Case of Aspiration Pneumonia Caused by Candida glabrata in a Non-neutropenic Patient with Candidemia
- Clinical Characteristics of Pneumonia Caused by Penicillin Resistant and Sensitive Streptococcus pneumoniae in Japan
- 42.喀血をきたし,診断に苦慮した気管支動脈瘤の1例(第33回 日本呼吸器内視鏡学会九州支部会)
- Ocular Pharmacokinetic/Pharmacodynamic Modeling for Multiple Anti-glaucoma Drugs
- Ocular Pharmacokinetic/Pharmacodynamic Modeling for Timolol in Rabbits Using a Telemetry System
- Transport of Timolol and Tilisolol in Rabbit Corneal Epithelium
- PEGylated Liposomes Loading Palmitoyl Prednisolone for Prolonged Blood Concentration of Prednisolone
- Antimicrobial Activity of Saturated Fatty Acids and Fatty Amines against Methicillin-Resistant Staphylococcus aureus
- Biliary Excretion of Mitomycin C Dextran Conjugates in Relation of Physicochemical Characteristics of Carrier Dextran
- Formulation and pharmacokinetic evaluation of tetracycline-loaded solid lipid nanoparticles for subcutaneous injection in mice
- Intracellular Trafficking Is the Important Process That Determines the Optimal Charge Ratio on Transfection by Galactosylated Lipoplex in HepG2 Cells(Biopharmacy)
- Effect of the Particle Size of Galactosylated Lipoplex on Hepatocyte-Selective Gene Transfection after Intraportal Administration(Biopharmacy)
- Effect of Low-Molecular-Weight β-Cyclodextrin Polymer on Release of Drugs from Mucoadhesive Buccal Film Dosage Forms(Biopharmacy)
- Lipid Carrier Systems for Targeted Drug and Gene Delivery
- Analysis of Hepatic Disposition of Native and Galactosylated Polyethylenimine Complexed with Plasmid DNA in Perfused Rat Liver
- 成人T細胞白血病/リンパ腫の危険因子 : 病型別の検討および人口寄与割合
- Formulation and Pharmacokinetic Evaluation of Tetracycline-Loaded Solid Lipid Nanoparticles for Subcutaneous Injection in Mice
- Effect of Co-administration of Cationic Macromolecules on the In Vivo Disposition and situ Renal Disposition Characteristics of rhIL-11
- Hepatic Disposition Characteristics of Recombinant Human Interleukin-11 (rhIL-11) in the Perfused Rat Liver
- Development of the inclusive evaluation method for the percutaneous absorption III : Prediction of human dermal concentration of chemicals in various vehicles
- Prediction of skin permeability of compounds from their molecular structure
- 2D- and 3D-QSAR of carrier-mediated transport of beta-lactam antibiotics in Caco-2 cells
- Prediction of Human Skin Permeability Using a Combination of Molecular Orbital Calculations and Artificial Neural Network
- QSPR analysis on inhibition of recombinant CYP3A4 activity by structurally diverse compounds using genetic algorithm combined partial least squares method
- Theoretical Analysis of the Effect of Cutaneous Metabolism on Skin Permeation of Parabens Based on a Two-Layer Skin Diffusion/Metabolism Model
- Pharmacokinetic analysis of ^I-labeled medium chain fatty acid as a radiopharmaceutical for hepatic function based on beta-oxidation
- Effect of Medium-Chain Glycerides on the Membrane Transport of D-Glucose and Sulfanilic Acid in the Intestinal Brush-Border Membrane Vesicles
- EFFECT OF MEDIUM-CHAIN GLYCERIDES (MGK^[○!R]) ON THE INTESTINAL ABSORPTION AND THE HEPATOBILIARY TRANSPORT OF BROMTHYMOL BLUE
- Pharmacokinetic considerations regarding non-viral cancer gene therapy
- Pharmacokinetic Evaluation of Biodistribution Data Obtained with Radiolabeled Proteins in Mice
- Pharmacokinetic Analysis of the in Vivo Disposition of Chemically Modified Proteins in Rats : Effect of Radiolabeling Method
- STUDY ON THE ACTION OF PERCUTANEOUS PENETRATION ENHANCERS : EFFECT ON VARIOUS DRUGS WITH DIFFERENT PHYSICOCHEMICAL PROPERTIES
- Analysis of Drug Penetration through Skin Considering Donor Concentration Decrease
- EFFECTS OF MITOMYCIN C, 5-FLUOROURACIL AND CYCLOPHOSPHAMIDE ON DRUG ABSORPTION, ENZYME ACTIVITIES AND MUCOSAL LIPID COMPOSITION OF INTESTINE
- BIOPHARMACEUTICAL STUDIES ON ANTITUMOR DRUG-INDUCED GASTROINTESTINAL DAMAGES
- Role of Tyrosine and Tryptophan in Chemically Modified Serum Albumin on Its Tissue Distribution(Biopharmacy)
- Control of Plasma Cholesterol-Lowering Action of Probucol with Various Lipid Carrier Systems
- Exogenous Expression of Interferon-β in Cultured Brain Microvessel Endothelial Cells(Biochemistry/Molecular Biology)
- Expression and Visualization of a Human Interferon-β-Enhanced Green Fluorescent Protein Chimeric Molecule in Cultured Cells (Biochemistry/Molecular Biology)
- Cationic Liposome-Mediated Efficient Induction of Type I Interferons by a Low Dose of Poly I:Poly C in Mouse Cell Lines
- Transport Characteristics of Ebastine and Its Metabolites across Human Intestinal Epithelial Caco-2 Cell Monolayers
- Cellular Interaction and in Vitro Antitumor Activity of Lipophilic Mitomycin C Prodrugs(Pharmaceutical)
- Key Physiological Phenomena Governing Transgene Expression Based on Tissue Pressure-Mediated Transfection in Mice
- EVALUATION OF DRUG DISPOSITION IN BRAIN BY MOMENT ANALYSIS (II)
- Enhanced Gene Transfection in Macrophages by Histidine-Conjugated Mannosylated Cationic Liposomes
- Relationship between Drug Release of DE-310, Macromolecular Prodrug of DX-8951f, and Cathepsins Activity in Several Tumors(Biopharmacy)
- Hydrogen peroxide-mediated nuclear factor κB activation in both liver and tumor cells during initial stages of hepatic metastasis
- Influence of Cholesterol Composition on the Association of Serum Mannan-Binding Proteins with Mannosylated Liposomes(Analytical Biochemistry)
- Tissue-specific in vivo gene transfer characteristics following direct injection of plasmid DNA
- IMMUNOLOGICAL CONTROL OF DRUG ABSORPTION FROM THE GASTROINTESTINAL TRACT : EFFECT OF LOCAL ANAPHYLAXIS ON THE INTESTINAL ABSORPTION OF LOW MOLECULAR WEIGHT DRUGS IN THE RAT
- DRUG ABSORPTION FROM THE GASTROINTESTINAL TRACT AND IMMUNITY : THE MECHANISM OF THE DECREASED ABSORPTION OF SALICYLIC ACID DURING SYSTEMIC ANAPHYLAXIS. II
- DRUG ABSORPTION FROM THE GASTROINTESTINAL TRACT AND IMMUNITY : THE MECHANISM OF THE DECREASED ABSORPTION OF SALICYLIC ACID DURING SYSTEMIC ANAPHYLAXIS.I
- Deconvolution Analysis for Absorption and Metabolism of Aspirin in Microcapsules
- Effect of Vehicle Properties on Skin Penetration of Emedastine
- Molecular and Pharmacokinetic Properties of 222 Commercially Available Oral Drugs in Humans
- Nonviral Approaches Satisfying Various Requirements for Effective in Vivo Gene Therapy
- Tissue Distribution of ^In-Labeled Uricase Conjugated with Charged Dextrans and Polyethylene Glycol
- CONTROL OF IN VIVO FATE OF PROTEIN DRUGS USING CHEMICAL MODIFICATION WITH SUGARS
- INTESTINAL ABSORPTION OF HAPTENS IN RATS IMMUNIZED WITH PROTEIN-HAPTEN CONJUGATE : COMPARISON OF SULFANILIC ACID WITH P-AMINOBENZOIC ACID
- EVALUATION OF ABSORPTIVE BARRIER TO PEPTIDES AND IMPROVEMENT OF MUCOSAL ABSORPTION OF PEPTIDES BY VARIOUS APPROACHES
- Design and Evaluation of Monoclonal Antibody-Antitumor Agent Conjugate
- Cellular Interaction and in Vitro Antitumor Effect of Various Mitomycin C Prodrugs in Mitomycin C-Resistant L1210 Leukemia Cell Lines(Pharmaceutical)
- EFFECT OF TEMPERATURE ON INTESTINAL TRANSFER AND TISSUE UPTAKE OF SULFANILAMIDE AND AMINOPROPYRON IN VITRO
- CELLULAR INTERACTION AND ANTITUMOR ACTIVITY OF MITOMYCIN C PRODRUGS
- URINARY EXCRETION CHARACTERISTICS OF A POLYMERIC PRODRUG OF MITOMYCIN C, MITOMYCIN C-DEXTRAN CONJUGATE
- ENHANCED LYMPHATIC DELIVERY OF MIYOMYCIN C BY POLYMERIC MODIFICATION
- Effect of Polycyclic Aromatic Hydrocarbons on Generation and Efflux of Glutathione Conjugates in Primary Cultured Alveolar Epithelial Cells
- In Silico Approaches for Predicting ADME Properties of Drugs
- Biodistribution Characteristics of Surface Charge Improved Lysine Dendrimers after Intravenous Injection in Mice
- ANTITUMOR ACTIVITY OF LIPOPHILIC PRODRUGS OF MITOMYCIN C ENTRAPPED IN LIPOSOME OR O/W EMULSION
- DEVELOPMENT OF LIPOPHILIC MITOMYCIN C PRODRUGS AND THEIR APPLICATION TO LIPID DISPERSION SYSTEMS
- Bovine Serum Albumin as a Lyoprotectant for Preparation of DNA Dry Powder Formulations Using the Spray-Freeze Drying Method
- Evaluation of Long-Term Gene Expression in Mouse Liver Using PhiC31 Integrase and Hydrodynamic Injection
- Combination of Bubble Liposomes and High-Intensity Focused Ultrasound (HIFU) Enhanced Antitumor Effect by Tumor Ablation
- Sedative Effects of Inhaled Benzylacetone and Structural Features Contributing to Its Activity
- Factors Influencing the Surface Modification of Mesenchymal Stem Cells with Fluorescein-Pegylated Lipids