Role of Tyrosine and Tryptophan in Chemically Modified Serum Albumin on Its Tissue Distribution(Biopharmacy)
スポンサーリンク
概要
- 論文の詳細を見る
To investigate the effect of functional groups in bovine serum albumin (BSA) on its tissue distribution characteristics, tyrosine (Tyr) or tryptophan (Trp) residues of BSA were chemically modified by tetranitromethane (TNM) and 2-hydroxy-5-nitrobenzyl bromide (HNB), respectively. BSA was successfully modified with each reagent depending on the amount of the reagent added to the reaction mixture, and TNM- and HNB-modified BSA derivatives with different degrees of modification were obtained. Circular dichroism measurements showed that slight secondary and large tertiary changes were detectable as the degree of modification increased. After intravenous injection into mice, all synthetic BSA derivatives were eliminated very slowly from the systemic circulation. However, ^<111>In-TNM_<6.6>- and ^<111>In-HNB_<2.0>-BSA, derivatives with a high degree of modification, showed a slightly faster disappearance from the systemic circulation and slightly higher accumulation in the liver than ^<111>In-unmodified BSA. Pharmacokinetic analyses also demonstrated that the modification of Tyr or Trp residues on BSA had only marginal effects on tissue distribution. These results indicate that the Tyr and Trp residues have little effect on the tissue distribution characteristics of serum albumins, and that the specific modification of these residues may be a promising approach to designing sustained drug delivery systems using serum albumins.
- 公益社団法人日本薬学会の論文
- 2006-09-01
著者
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Yamashita Fumiyoshi
第一三共 葛西研究開発センター
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Yamashita Fumiyoshi
Department Of Drug Delivery Research Graduate School Of Pharmaceutical Sciences Kyoto University
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Yamashita Fumiyoshi
Departments Of Drug Delivery Research Graduate School Of Pharmaceutical Sciences Kyoto University
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Yamashita Fumiyoshi
Graduate School Of Pharmaceutical Sciences Kyoto University
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Hashida Mitsuru
第一三共 葛西研究開発センター
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Hashida Mitsuru
Department Of Basic Pharmaceutics Faculty Of Pharmaceutical Sciences Kyoto University
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Hashida Mitsuru
京都大学 薬学研究科病態情報薬学
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Hashida Mitsuru
Dep. Of Drug Delivery Res. Graduate School Of Pharmaceutical Sciences Kyoto Univ. 46-29 Yoshidashimo
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Hashida Mitsuru
Inst. Of Integrated Cell-material Sciences (icems) Kyoto Univ.
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Yamashita Fumiyoshi
Dep. Of Drug Delivery Res. Graduate School Of Pharmaceutical Sciences Kyoto Univ. 46-29 Yoshidashimo
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Ma Shen-feng
Department Of Drug Delivery Research Graduate School Of Pharmaceutical Sciences Kyoto University
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YABE Yoshiyuki
Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University
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NISHIKAWA Makiya
Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University
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Yabe Yoshiyuki
Department Of Drug Delivery Research Graduate School Of Pharmaceutical Sciences Kyoto University
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Hashida M
Department Of Drug Delivery Research Graduate School Of Pharmaceutical Sciences Kyoto University
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Hashida Mitsuru
Graduate School Of Pharmaceutical Sciences Kyoto University
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YAMASHITA Fumiyoshi
京大院薬
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HASHIDA Mitsuru
京大院薬
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Nishikawa Makiya
Department Of Biopharmaceutics And Drug Metabolism Graduate School Of Pharmaceutical Science Kyoto U
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Nishikawa Makiya
京都大学 薬学研究科病態情報薬学
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Yamashita Fumiyoshi
Dep. Of Drug Delivery Res. Graduate School Of Pharmaceutical Sciences Kyoto Univ.
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Nishikawa Makiya
Department Of Biopharmaceutics And Drug Metabolism Graduate School Of Pharmaceutical Sciences Kyoto
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