Pharmacokinetic analysis of ^<123>I-labeled medium chain fatty acid as a radiopharmaceutical for hepatic function based on beta-oxidation
スポンサーリンク
概要
著者
-
Saji Hideo
Department Of Patho-functional Bioanalysis Graduate School Of Pharmaceutical Sciences Kyoto Universi
-
Yamashita Fumiyoshi
Department Of Drug Delivery Research Graduate School Of Pharmaceutical Sciences Kyoto University
-
Hashida Mitsuru
Department Of Basic Pharmaceutics Faculty Of Pharmaceutical Sciences Kyoto University
-
Hashida Mitsuru
Department Of Drug Delivery Research Graduate School Of Pharmaceutical Sciences Kyoto University
-
MAGATA Yasuhiro
Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto Univer
-
Magata Yasuhiro
Department Of Nuclear Medicine Graduate School Of Medicine
-
YAMAMURA Norio
Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences
-
Yamamura Norio
Department Of Drug Metabolism And Pharmacokinetics Kawanishi Pharma Research Institute Nippon Boehri
-
Yamamura Norio
Department Of Patho-functional Bioanalysis Graduate School Of Pharmaceutical Sciences
-
Saji Hideo
Department Of Patho-functional Bioanalysis Graduate School Of Pharmaceutical Sciences
-
Saji Hideo
Department Of Cardiology Matsushita Memorial Hosipital
関連論文
- Noninvasive Evaluation of Regional Myocardial Perfusion with Positron Emission Computed Tomography : PANEL DISCUSSION ON PROGRESS IN NONINVASIVE CARDIAC DIAGNOSIS
- Biliary Excretion of Mitomycin C Dextran Conjugates in Relation of Physicochemical Characteristics of Carrier Dextran
- Development of a Radiolabeled Probe for Detecting Membrane Type-1 Matrix Metalloproteinase on Malignant Tumors
- Prominent Lectin-Like Oxidized Low Density Lipoprotein (LDL) Receptor-1 (LOX-1) Expression in Atherosclerotic Lesions Is Associated with Tissue Factor Expression and Apoptosis in Hypercholesterolemic Rabbits(Analytical Biochemistry)
- Distribution Profiles of Membrane Type-1 Matrix Metalloproteinase (MT1-MMP), Matrix Metalloproteinase-2 (MMP-2) and Cyclooxygenase-2 (COX-2) in Rabbit Atherosclerosis : Comparison with Plaque Instability Analysis(Analytical Biochemistry)
- Chemical Control of Biological Activity and Biodistribution of Metal Compounds : Drug Design of Metal Complexes with Biological Activity and Target-Specific Biodistribution
- PJ-071 Expression of Lectin-like Oxidized LDL Receptor-1 in Atherosclerotic lesions : Comparison with Tissue Factor Expression and Apoptosis in WHHLMI Rabbits(Atherosclerosis, basic-8, The 71st Annual Scientific Meeting of the Japanese Circulation Society
- Performance assessment of O-18 water purifier
- Mechanisms of [2,3-Butanedione Bis(N^4-Dimethylthiosemicarbazone)] zinc(Zn-ATSM_2)-Induced Protection of Cultured Hippocampal Neurons Against N-Methyl-_D-Aspartate Receptor-Mediated Glutamate Cytotoxicity
- Formulation and pharmacokinetic evaluation of tetracycline-loaded solid lipid nanoparticles for subcutaneous injection in mice
- Intracellular Trafficking Is the Important Process That Determines the Optimal Charge Ratio on Transfection by Galactosylated Lipoplex in HepG2 Cells(Biopharmacy)
- Effect of the Particle Size of Galactosylated Lipoplex on Hepatocyte-Selective Gene Transfection after Intraportal Administration(Biopharmacy)
- Effect of Low-Molecular-Weight β-Cyclodextrin Polymer on Release of Drugs from Mucoadhesive Buccal Film Dosage Forms(Biopharmacy)
- Lipid Carrier Systems for Targeted Drug and Gene Delivery
- Analysis of Hepatic Disposition of Native and Galactosylated Polyethylenimine Complexed with Plasmid DNA in Perfused Rat Liver
- Assessment of coronary vasodilator reserve by N-13 ammonia PET using the microsphere method and Patlak plot analysis
- 5-[^I]Iodo-A-85380 : assessment of pharmacological safety, radiation dosimetry and SPECT imaging of brain nicotinic receptors in healthy human subjects
- Relation of Change in Wall Motion and Glucose Metabolism After Coronary Artery Bypass Grafting : Assessment with positron emission tomography : 54th Annual Scientific Session of the Japanese Circulation Society
- Formulation and Pharmacokinetic Evaluation of Tetracycline-Loaded Solid Lipid Nanoparticles for Subcutaneous Injection in Mice
- Effect of Co-administration of Cationic Macromolecules on the In Vivo Disposition and situ Renal Disposition Characteristics of rhIL-11
- Hepatic Disposition Characteristics of Recombinant Human Interleukin-11 (rhIL-11) in the Perfused Rat Liver
- Development of the inclusive evaluation method for the percutaneous absorption III : Prediction of human dermal concentration of chemicals in various vehicles
- Prediction of skin permeability of compounds from their molecular structure
- 2D- and 3D-QSAR of carrier-mediated transport of beta-lactam antibiotics in Caco-2 cells
- Prediction of Human Skin Permeability Using a Combination of Molecular Orbital Calculations and Artificial Neural Network
- QSPR analysis on inhibition of recombinant CYP3A4 activity by structurally diverse compounds using genetic algorithm combined partial least squares method
- Theoretical Analysis of the Effect of Cutaneous Metabolism on Skin Permeation of Parabens Based on a Two-Layer Skin Diffusion/Metabolism Model
- Pharmacokinetic analysis of ^I-labeled medium chain fatty acid as a radiopharmaceutical for hepatic function based on beta-oxidation
- Effect of Medium-Chain Glycerides on the Membrane Transport of D-Glucose and Sulfanilic Acid in the Intestinal Brush-Border Membrane Vesicles
- EFFECT OF MEDIUM-CHAIN GLYCERIDES (MGK^[○!R]) ON THE INTESTINAL ABSORPTION AND THE HEPATOBILIARY TRANSPORT OF BROMTHYMOL BLUE
- Pharmacokinetic considerations regarding non-viral cancer gene therapy
- Pharmacokinetic Evaluation of Biodistribution Data Obtained with Radiolabeled Proteins in Mice
- Pharmacokinetic Analysis of the in Vivo Disposition of Chemically Modified Proteins in Rats : Effect of Radiolabeling Method
- STUDY ON THE ACTION OF PERCUTANEOUS PENETRATION ENHANCERS : EFFECT ON VARIOUS DRUGS WITH DIFFERENT PHYSICOCHEMICAL PROPERTIES
- Analysis of Drug Penetration through Skin Considering Donor Concentration Decrease
- EFFECTS OF MITOMYCIN C, 5-FLUOROURACIL AND CYCLOPHOSPHAMIDE ON DRUG ABSORPTION, ENZYME ACTIVITIES AND MUCOSAL LIPID COMPOSITION OF INTESTINE
- BIOPHARMACEUTICAL STUDIES ON ANTITUMOR DRUG-INDUCED GASTROINTESTINAL DAMAGES
- In Vivo Measurement of Presynaptic Zn^ Release during Forebrain Ischemia in Rats(Pharmacology)
- Role of Tyrosine and Tryptophan in Chemically Modified Serum Albumin on Its Tissue Distribution(Biopharmacy)
- Control of Plasma Cholesterol-Lowering Action of Probucol with Various Lipid Carrier Systems
- Radioimmunodetection of Membrane Type-1 Matrix Metalloproteinase Relevant to Tumor Malignancy with a Pre-targeting Method
- Beneficial Effects of Reperfusion Therapy in Elderly or Super-Elderly Patients with Acute Myocardial Infarction(Acute Myocardial Infarction, Clinical (Diagnosis/Treatment) 8 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Exogenous Expression of Interferon-β in Cultured Brain Microvessel Endothelial Cells(Biochemistry/Molecular Biology)
- Expression and Visualization of a Human Interferon-β-Enhanced Green Fluorescent Protein Chimeric Molecule in Cultured Cells (Biochemistry/Molecular Biology)
- Cationic Liposome-Mediated Efficient Induction of Type I Interferons by a Low Dose of Poly I:Poly C in Mouse Cell Lines
- Brain Extraction of 4-(4-Chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]pyridinium Ion (HPP^+), a Neurotoxic Metabolite of Haloperidol : Studies Using [^3H]HPP^+
- Ginseng Pretreatment Protects against Transient Global Cerebral Ischemia in the Rat : Measurement of Local Cerebral Glucose Utilization by [^C]Deoxyglucose Autoradiography
- Transport Characteristics of Ebastine and Its Metabolites across Human Intestinal Epithelial Caco-2 Cell Monolayers
- Cellular Interaction and in Vitro Antitumor Activity of Lipophilic Mitomycin C Prodrugs(Pharmaceutical)
- Key Physiological Phenomena Governing Transgene Expression Based on Tissue Pressure-Mediated Transfection in Mice
- EVALUATION OF DRUG DISPOSITION IN BRAIN BY MOMENT ANALYSIS (II)
- FRS-015 The Feasibility of ^Tc-Annexin V to Evaluate the Anti-atherosclerotic Therapy by HMG-CoA Reductase Inhibitor Pravastatin in Cholesterol-fed Rabbits(Topics in Nuclear Cardiology(I),Featured Research Session,The 72nd Annual Scientific Meeting o
- Enhanced Gene Transfection in Macrophages by Histidine-Conjugated Mannosylated Cationic Liposomes
- Protective Effect of Zinc Against Ischemic Neuronal Injury in a Middle Cerebral Artery Occlusion Model
- Relationship between Drug Release of DE-310, Macromolecular Prodrug of DX-8951f, and Cathepsins Activity in Several Tumors(Biopharmacy)
- Hydrogen peroxide-mediated nuclear factor κB activation in both liver and tumor cells during initial stages of hepatic metastasis
- Influence of Cholesterol Composition on the Association of Serum Mannan-Binding Proteins with Mannosylated Liposomes(Analytical Biochemistry)
- Tissue-specific in vivo gene transfer characteristics following direct injection of plasmid DNA
- Population pharmacokinetics of epinastine, a histamine H_1 receptor antagonist, in adults and children
- IMMUNOLOGICAL CONTROL OF DRUG ABSORPTION FROM THE GASTROINTESTINAL TRACT : EFFECT OF LOCAL ANAPHYLAXIS ON THE INTESTINAL ABSORPTION OF LOW MOLECULAR WEIGHT DRUGS IN THE RAT
- DRUG ABSORPTION FROM THE GASTROINTESTINAL TRACT AND IMMUNITY : THE MECHANISM OF THE DECREASED ABSORPTION OF SALICYLIC ACID DURING SYSTEMIC ANAPHYLAXIS. II
- DRUG ABSORPTION FROM THE GASTROINTESTINAL TRACT AND IMMUNITY : THE MECHANISM OF THE DECREASED ABSORPTION OF SALICYLIC ACID DURING SYSTEMIC ANAPHYLAXIS.I
- The Diagnostic Impact of ^Tc-Tetrofosmin Myocardial SPECT on Angiogenesis Between Bone Marrow-and Peripheral Blood-derived Mononuclear Cells in Ischemia-Reperfusion Model(Nuclear Cardiology 9 (I), The 69th Annual Scientific Meeting of the Japanese Ci
- The Feasibility of ^Tc-Annexin V to Quantitatively Evaluate Cardioprotective Effect of Erythropoietin in an Acute Ischemia-reperfusion Rat Model(Advances in Nuclear Cardiology (I), The 69th Annual Scientific Meeting of the Japanese Circulation Societ
- Deconvolution Analysis for Absorption and Metabolism of Aspirin in Microcapsules
- Effect of Vehicle Properties on Skin Penetration of Emedastine
- Molecular and Pharmacokinetic Properties of 222 Commercially Available Oral Drugs in Humans
- Nonviral Approaches Satisfying Various Requirements for Effective in Vivo Gene Therapy
- Tissue Distribution of ^In-Labeled Uricase Conjugated with Charged Dextrans and Polyethylene Glycol
- CONTROL OF IN VIVO FATE OF PROTEIN DRUGS USING CHEMICAL MODIFICATION WITH SUGARS
- INTESTINAL ABSORPTION OF HAPTENS IN RATS IMMUNIZED WITH PROTEIN-HAPTEN CONJUGATE : COMPARISON OF SULFANILIC ACID WITH P-AMINOBENZOIC ACID
- EVALUATION OF ABSORPTIVE BARRIER TO PEPTIDES AND IMPROVEMENT OF MUCOSAL ABSORPTION OF PEPTIDES BY VARIOUS APPROACHES
- Design and Evaluation of Monoclonal Antibody-Antitumor Agent Conjugate
- Cellular Interaction and in Vitro Antitumor Effect of Various Mitomycin C Prodrugs in Mitomycin C-Resistant L1210 Leukemia Cell Lines(Pharmaceutical)
- EFFECT OF TEMPERATURE ON INTESTINAL TRANSFER AND TISSUE UPTAKE OF SULFANILAMIDE AND AMINOPROPYRON IN VITRO
- CELLULAR INTERACTION AND ANTITUMOR ACTIVITY OF MITOMYCIN C PRODRUGS
- URINARY EXCRETION CHARACTERISTICS OF A POLYMERIC PRODRUG OF MITOMYCIN C, MITOMYCIN C-DEXTRAN CONJUGATE
- ENHANCED LYMPHATIC DELIVERY OF MIYOMYCIN C BY POLYMERIC MODIFICATION
- Effect of Polycyclic Aromatic Hydrocarbons on Generation and Efflux of Glutathione Conjugates in Primary Cultured Alveolar Epithelial Cells
- In Silico Approaches for Predicting ADME Properties of Drugs
- Biodistribution Characteristics of Surface Charge Improved Lysine Dendrimers after Intravenous Injection in Mice
- ANTITUMOR ACTIVITY OF LIPOPHILIC PRODRUGS OF MITOMYCIN C ENTRAPPED IN LIPOSOME OR O/W EMULSION
- DEVELOPMENT OF LIPOPHILIC MITOMYCIN C PRODRUGS AND THEIR APPLICATION TO LIPID DISPERSION SYSTEMS
- Relationship between Pharmacokinetic Parameters and Occurrence of Adverse Events in Clinical Trials Performed in Europe and United States for an Angiotensin II Receptor Antagonist, Telmisartan
- Pharmacokinetic Comparison of an Angiotensin II Receptor Antagonist, Telmisartan, in Japanese and Western Hypertensive Patients Using Population Pharmacokinetic Method
- Population Pharmacokinetics of an Angiotensin II Receptor Antagonist, Telmisartan, in Healthy Volunteers and Hypertensive Patients
- Resolution of Evolutionary Conflict : a General Theory and Its Applications
- Optimal strategy of plant antiherbivore defense : Implications for apparency and resource-availability theories
- Evaluation of [^I]IPOS as a molecular imaging probe for hypoxia-inducible factor-1-active regions in a tumor : Comparison among single-photon emission computed tomography/X-ray computed tomography imaging, autoradiography, and immunohistochemistry
- In Vivo Tumor Accumulation of Arginine-Rich Cell-penetrating Peptides and Anticancer Drug Delivery
- Development of membrane type-1 matrix metalloproteinase-specific activatable fluorescent probe for malignant tumor detection
- Bovine Serum Albumin as a Lyoprotectant for Preparation of DNA Dry Powder Formulations Using the Spray-Freeze Drying Method
- Evaluation of Long-Term Gene Expression in Mouse Liver Using PhiC31 Integrase and Hydrodynamic Injection
- In Vivo Evaluation of a Radiogallium-Labeled Bifunctional Radiopharmaceutical, Ga-DOTA-MN2, for Hypoxic Tumor Imaging
- Combination of Bubble Liposomes and High-Intensity Focused Ultrasound (HIFU) Enhanced Antitumor Effect by Tumor Ablation
- Sedative Effects of Inhaled Benzylacetone and Structural Features Contributing to Its Activity