Protective Effect of Zinc Against Ischemic Neuronal Injury in a Middle Cerebral Artery Occlusion Model
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概要
- 論文の詳細を見る
In this study, we investigated the effect of vesicular zinc on ischemic neuronal injury. In cultured neurons, addition of a low concentration (under 100 μM) of zinc inhibited both glutamate-induced calcium influx and neuronal death. In contrast, a higher concentration (over 150 μM) of zinc decreased neuronal viability, although calcium influx was inhibited. These results indicate that zinc exhibits biphasic effects depending on its concentration. Furthermore, in cultured neurons, co-addition of glutamate and CaEDTA, which binds extra-cellular zinc, increased glutamate-induced calcium influx and aggravated the neurotoxicity of glutamate. In a rat transient middle cerebral artery occlusion (MCAO) model, the infarction volume, which is related to the neurotoxicity of glutamate, increased rapidly on the intracerebral ventricular injection of CaEDTA 30 min prior to occlusion. These results suggest that zinc released from synaptic vesicles may provide a protective effect against ischemic neuronal injury.
- 社団法人 日本薬理学会の論文
- 2006-02-20
著者
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Saji H
Graduate School Of Pharmaceutical Sciences Kyoto University
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Saji Hideo
明治鍼灸大学
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Saji Hideo
Department Of Patho-functional Bioanalysis Graduate School Of Pharmaceutical Sciences Kyoto Universi
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Saji Hideo
茨城県立医療大学 放射線技術科学
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石井 靖
福井医科大学放射線部
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Saji Hideo
Graduate School Of Pharmaceutical Sciences Kyoto University
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IIDA Yasuhiko
Department of Bioimaging Information Analysis, Gunma University Graduate School of Medicine
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Kitamura Youji
Department Of Pharmaceutical Sciences Graduate School Of Medicine And Dentistry And Pharmaceutical S
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Saito Yutaka
Department Of Pharmaceutical Sciences Graduate School Of Medicine And Dentistry And Pharmaceutical S
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KITAMURA Youji
Graduate School of Medicine and Dentistry and Pharmaceutical Sciences, Okayama University
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ISHII Yasushi
Department of Radiology
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UEDA Masashi
Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto Univer
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Saito Y
Department Of Pharmaceutical Sciences Graduate School Of Medicine And Dentistry And Pharmaceutical S
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Ida Yuko
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Universit
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Ishii Yasushi
Third Division Dept. Of Internal Medicine And Nuclear Medicine
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Kasuya F
Faculty Of Pharmaceutical Sciences And High Technology Research Center Kobe Gakuin University
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Kasuya Fumiyo
Department Of Toxicology Pharmaceutical Sciences Kobegakuin University
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Kasuya Fumiyo
Laboratory Of Biochemical Toxicology Faculty Of Pharmaceutical Sciences Kobegakuin University
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Iida Y
Department Of Bioimaging Medical Sciences Gunma University
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Iida Yasuhiko
Department Of Bioimaging Medical Sciences Gunma University
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Iida Yasuhiko
Department Of Radiopharmaceutical Chemistry Faculty Of Pharmaceutical Sciences Kyoto University
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Igarashi Kazuo
Department Of Chemistry Virginia Polytechnic Institute And State University
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Igarashi K
Faculty Of Pharmaceutical Sciences And High Technology Research Center Kobe Gakuin University
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Sakahara H
Department Of Radiology Hamamatsu University School Of Medicine
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Ohta Masayuki
Department Of Surgery I Oita University Faculty Of Medicine
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Ohta Masayuki
Department Of Toxicology Pharmaceutical Sciences Kobegakuin University
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ABE Jun
Department of Patho-functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto Univer
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MIFUNE Masaki
Graduate School of Medicine and Dentistry and Pharmaceutical Sciences, Okayama University
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SAITO Yutaka
Graduate School of Medicine and Dentistry and Pharmaceutical Sciences, Okayama University
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Mifune Masaki
Department Of Pharmaceutical Sciences Graduate School Of Medicine And Dentistry And Pharmaceutical S
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Saji Hideo
Dep. Of Patho-functional Bioanalysis Graduate School Of Pharmaceutical Sciences Kyoto Univ.
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Kuge Yuji
Department Of Patho-functional Bioanalysis Graduate School Of Pharmaceutical Sciences Kyoto Universi
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Ueda Masashi
Department Of Patho-functional Bioanalysis Graduate School Of Pharmaceutical Sciences Kyoto Universi
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Kitamura Youji
Department Of Patho-functional Bioanalysis Graduate School Of Pharmaceutical Sciences Kyoto Universi
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Sakahara H
Kyoto Univ. School Of Medicine
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Kasuya Fumiyo
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Ueda Masashi
Department Of Anesthesiology And Reanimatology Faculty Of Medical Sciences University Of Fukui
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Saji Hideo
Department Of Cardiology Matsushita Memorial Hosipital
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Abe Jun
Department Of Biology Faculty Of Science Kobe University
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Ohta Masayuki
Department Of Neuropsychiatry Hyogo College Of Medicine
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Abe Jun
Department Of Patho-functional Bioanalysis Graduate School Of Pharmaceutical Sciences Kyoto Universi
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Abe Jun
Department Of Allergy And Immunology National Research Institute For Child Health And Development
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Abe Jun
Department Of Agricultural And Environmental Biology Graduate School Of Agricultural And Life Scienc
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Ohta Masayuki
Department of Applied Chemistry, Graduate School of Engineering, Nagoya University
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Saito Yutaka
Department of Pharmaceutical Sciences, Graduate School of Medicine and Dentistry and Pharmaceutical Sciences, Okayama University
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Mifune Masaki
Department of Pharmaceutical Sciences, Graduate School of Medicine and Dentistry and Pharmaceutical Sciences, Okayama University
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