Effect of Carboxyl-Group of D-Glutamic Acid or γ-Carboxy-D-glutamic Acid as N-Terminal Amino Acid of ^<111>In-Diethylenetriaminepentaacetic Acid-Octreotide on Accumulation of Radioactivity in Kidney(Miscellaneous)
スポンサーリンク
概要
- 論文の詳細を見る
To establish a strategy for developing ^<111>In-diethylenetriaminepentaacetic acid (^<111>In-DTPA)-octreotide, a diagnostic radiopharmaceutical agent for tumors, with reduced non-specific renal radio-accumulation, the compounds having D-glutamic acid (Glu) or γ-carboxy-D-glutamic acid (carboxy-Glu) as the N-terminal amino acid were examined for in vivo radio-distribution. Compounds carrying Glu and carboxy-Glu containing one and two negative charges, respectively, showed lower renal radio-accumulation than that carrying D-phenylalanine. It was revealed that the introduction of a negative charge reduces the renal radio-accumulation independently from the number of negative charges. The present result can be a clue for the development of ^<111>In-DTPA-octreotides with reduced the renal radio-accumulation.
- 公益社団法人日本薬学会の論文
- 2007-11-01
著者
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Saji H
Graduate School Of Pharmaceutical Sciences Kyoto University
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Saji Hideo
明治鍼灸大学
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Saji Hideo
茨城県立医療大学 放射線技術科学
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Saji Hideo
Graduate School Of Pharmaceutical Sciences Kyoto University
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Kitamura Youji
Department Of Pharmaceutical Sciences Graduate School Of Medicine And Dentistry And Pharmaceutical S
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Saito Yutaka
Department Of Pharmaceutical Sciences Graduate School Of Medicine And Dentistry And Pharmaceutical S
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Saito Y
Department Of Pharmaceutical Sciences Graduate School Of Medicine And Dentistry And Pharmaceutical S
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Saito M
Tsukuba Research Drug Safety Research Laboratories Eisai Co. Ltd.
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Saito Mariko
Department Of Pharmacology Toho University School Of Pharmaceutical Sciences
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Arano Y
Graduate School Of Pharmaceutical Sciences Chiba University
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Arano Yasushi
Graduate School Of Pharmaceutical Sciences Chiba University
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Sakahara H
Department Of Radiology Hamamatsu University School Of Medicine
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SAITO Madoka
Faculty of Pharmaceutical Sciences, Mukogawa Women's University
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TSUKAMOTO Ikuko
Faculty of Medicine, Kagawa University
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MIFUNE Masaki
Department of Pharmaceutical Sciences, Graduate School of Medicine and Dentistry and Pharmaceutical
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AKIZAWA Hiromichi
Graduate School of Pharmaceutical Sciences, Chiba University
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OHKURA Tatsuya
Department of Pharmaceutical Chemistry, Graduate School of Natural Science and Technology, Okayama U
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SHIMIZU Takaya
Department of Pharmaceutical Sciences, Graduate School of Medicine and Dentistry and Pharmaceutical
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Mifune Masaki
Department Of Pharmaceutical Sciences Graduate School Of Medicine And Dentistry And Pharmaceutical S
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Saji Hideo
Dep. Of Patho-functional Bioanalysis Graduate School Of Pharmaceutical Sciences Kyoto Univ.
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Kuge Yuji
Department Of Patho-functional Bioanalysis Graduate School Of Pharmaceutical Sciences Kyoto Universi
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Ohkura Tatsuya
Department Of Pharmaceutical Chemistry Graduate School Of Natural Science And Technology Okayama Uni
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Shimizu Takaya
Department Of Pharmaceutical Sciences Graduate School Of Medicine And Dentistry And Pharmaceutical S
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Kitamura Youji
Department Of Patho-functional Bioanalysis Graduate School Of Pharmaceutical Sciences Kyoto Universi
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Sakahara H
Kyoto Univ. School Of Medicine
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Tsukamoto Ikuko
Faculty Of Medicine Kagawa University
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Akizawa Hiromichi
Graduate School Of Pharmaceutical Sciences Chiba University
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Saito Yutaka
Department Of Endoscopy National Cancer Center Hospital
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Saji Hideo
Graduate School Of Pharmaceutical Sciences Kyoto Univ.
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Saito Madoka
Faculty of Pharmaceutical Sciences, Mukogawa Women's University
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Saito Yutaka
Department of Pharmaceutical Sciences, Graduate School of Medicine and Dentistry and Pharmaceutical Sciences, Okayama University
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Mifune Masaki
Department of Pharmaceutical Sciences, Graduate School of Medicine and Dentistry and Pharmaceutical Sciences, Okayama University
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Saito Yutaka
Department of Chemistry, Nagaoka University of Technology
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