Aminopropyl-Silica Gel Modified with Nickel(II)-Phthalocyanine for Separation of π-Electron Rich Compounds by High Performance Liquid Chromatography

概要

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Aminopropyl-silica gels modified with a nickel(II)-phthalocyanine derivative (Ni-PCS_D) were evaluated as HPLC-stationary phases for the separation of π-electron rich compounds such as polyaromatic hydrocarbons (PAHs) and mutagens. A column packed with Ni-PCS_D retains some π-electron rich compounds longer than a column packed with copper(II)-phthalocyanine derivatives (Cu-PCS_D), suggesting that a π-π electron interaction and an additional interaction between Ni-PCS and the compound. On the basis of the retention data of fourring PAHs, anthracene derivatives and heterocyclic aromatic hydrocarbons, we propose that the additional interaction would be due to an interference of the π- or n-electrons would interact and with the d-orbital of the Ni atom in Ni-PCS. Further, the Ni-PCS_D column is expected to be superior to the Cu-PCS_D column for the separations of drugs, mutagens and pollutants which have both π-electrons and ligand atom(s).
公益社団法人日本薬学会の論文
1999-03-15