Purines. LXXIX. Synthesis and Hydrolysis of 3-Methoxyadenine and Its N^6-Benzyl Derivative Leading to the Corresponding 2-Hydroxyadenines

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概要

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• Methylation of adenine 3-oxide (8a) with MeI in AcNMe_2 afforded 3-emthoxyadenine (9a) in 44% yield. This compound (9a) underwent hydroxide-ion attack at the 2-position to give 2-hydroxyadenine (isoguanine) (10a) in 38% yield. A parallel reaction sequence starting from N^6-benzyladenine 3-oxide (8c) and proceeding through N^6-benzyl-3-methoxyadenine (9c) provided N^6-benzyl-2-hydroxyadenine (10c) in 29% overall yield, together with a small amount of N^6-benzyladenine (11c).

• 公益社団法人日本薬学会の論文
• 1999-04-15

著者

• 藤井 澄三

  金沢大学薬学部

• Itaya T

  Faculty Of Pharmaceutical Sciences Kanazawa University

• KANEKO Masafumi

  Faculty of Pharmaceutical Sciences, Kyushu University

• ITAYA Taisuke

  Faculty of Pharmaceutical Sciences, Kanazawa University

• KANAI Tae

  Faculty of Pharmaceutical Sciences, Kanazawa University

• Kanai T

  Faculty Of Pharmaceutical Sciences Kanazawa University

• Kanai Tae

  Faculty Of Pharmaceutical Sciences Kanazawa University

• Kaneko M

  Faculty Of Pharmaceutical Sciences Kyushu University

• Itaya Taisuke

  Faculty Of Pharmaceutical Sciences Kanazawa University

• TAKADA Yasutaka

  Faculty of Pharmaceutical Sciences, Kanazawa University

• KANEKO Miki

  Faculty of Pharmaceutical Sciences, Kanazawa University

• YASUHARA Kensuke

  Faculty of Pharmaceutical Sciences, Kanazawa University

• FUJII Tozo

  Faculty of Pharmaceutical Sciences, Kanazawa University

• Fujii Tozo

  Faculty Of Pharmaceutical Sciences Kanazawa University

• Takada Y

  Rikkyo Univ. Tokyo Jpn

• Takada Yasutaka

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 藤井 澄三

  Shinshu Univ. Nagano Jpn

• Yasuhara Kensuke

  Faculty Of Pharmaceutical Sciences Kanazawa University

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