Quinolizidines. XXVII. Racemic and chiral syntheses of the Neisosperma and Ochrosia alkaloid ochropposinine

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概要

• 論文の詳細を見る

• The first total synthesis of ochropposinine (1), a Neisosperma and Ochrosia alkaloid, has been accomplished in the form of a racemic modification by means of an initial coupling of the lactim ether (±)-3 with 5 and succeeding steps proceeding through the intermediates (±)-7,(±)-8,(±)-9,(±)-10,and (±)-11. A parallel synthetic route starting with (+)-3 produced the chiral target molecule (-)-1 via the intermediates (+)-7,(+)-8,(+)-9,10,and (-)-11. As a result, the absolute configuration of ochropposinine has been unequivocally established to be that represented by formula (-)-1.

• 公益社団法人日本薬学会の論文
• 1990-05-25

著者

• 宮嶋 久栄

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 藤井 澄三

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 大場 正志

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 大場 正志

  Kanazawa Univ. Ishikawa Jpn

• Ohba M

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 藤井 澄三

  Shinshu Univ. Nagano Jpn

• 立浪 毅

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 宮嶋 久栄

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 立浪 毅

  Faculty Of Pharmaceutical Sciences Kanazawa University

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