Purines. LVIII. A Synthesis of 7-Alkyl-1-methyladenines from Adenosine by Regioselective Alkylation : Uilization of a 1-Methoxy Group as a Control Synthon
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概要
- 論文の詳細を見る
A general synthetic route to 7-alkyl-1-methyladenine (8) from N^6-methoxy-1-methyladenosine (5) in three steps [hence from adenosine (1) in seven steps] has been established. The route started with alkylation of 5,readily obtainable from 1 in four steps according to previously reported procedures, and proceeded through glycosidic methanolysis of the resulting 7-alkylated nucleoside (6) and removal of the N^6-methoxy group by catalytic hydrogenolysis.
- 公益社団法人日本薬学会の論文
- 1993-11-15
著者
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斎藤 徹
Faculty Of Pharmaceutical Sciences Kanazawa University
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藤井 澄三
Faculty Of Pharmaceutical Sciences Kanazawa University
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藤井 澄三
金沢大学薬学部
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伊井 陵子
Faculty of Pharmaceutical Sciences, Kanazawa University
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山本 清美
Faculty of Pharmaceutical Sciences, Kanazawa University
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山本 清美
Faculty Of Pharmaceutical Sciences Kanazawa University
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藤井 澄三
Shinshu Univ. Nagano Jpn
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伊井 陵子
Faculty Of Pharmaceutical Sciences Kanazawa University
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