Decalcification of Calcium Polycarbophil in Rats
スポンサーリンク
概要
- 論文の詳細を見る
The in vivo decalcification of calcium polycarbophil was examined. The decalcification ratio of [^<43>Ca]calcium polycarbophil in the stomach after oral dosing to rats was more than 70% at each designated time and quite closely followed the in vitro decalcification curve, indicating that hte greater part of the calcium ion is released from calcium polycarbophil under normal gastric acidic conditions. The residual radioactivity in rat gastrointestine was nearly equal to that after oral administration of either [^<45>Ca]calcium chloride or [^<45>Ca]calcium chloride+polycarbophil. The serum level of radioactivity was nearly equal to that after oral dosing of [^<45>Ca]calcium lactate. These results indicate that the greater part of orally administered calcium polycarbophil released calcium ions to produce polycarbophil in vivo.
- 公益社団法人日本薬学会の論文
- 1997-03-15
著者
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斎藤 徹
Faculty Of Pharmaceutical Sciences Kanazawa University
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Tsuji Akira
金沢大学 薬
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Tsuji Akira
富山化学工業綜合研究所
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Tsuji A
Kanazawa Univ. Ishikawa Jpn
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Nagata O
Pharmaceutical Research Laboratory Hokuriku Seiyaku Co. Ltd.
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Tamai I
Tokyo Univ. Sci. Tokyo Jpn
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Tamai Ikumi
Meiji Seika Kaisha Ltd. Pharmaceutical Research Center:department Of Surgery Kawasaki City Ida Hospi
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Tamai Ikumi
Department Of Membrane Transport And Pharmacokinetics Faculty Of Pharmacy Institute Of Medical Pharm
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Tamai Ikumi
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kanazawa University
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Tamai Ikumi
Department Of Membrane Transport And Pharmacokinetics Faculty Of Pharmaceutical Sciences Tokyo Unive
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Tamai Ikumi
Faculty Of Pharmaceutical Sciences And Hospital Pharmacy Kanazawa University
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Tsuji Akira
Department Of Pediatrics:hospital Pharmacy:and Faculty Of Pharmaceutical Sciences University Of Kana
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Suzuki T
Drug Discovery Research Laboratory Sanwa Kagaku Kenkyusho Co. Ltd.
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Nagata Osamu
Research And Development Division Hokuriku Seiyaku Co. Ltd.
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Suzuki T
Laboratory Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Chiba University
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SAITO Takaharu
Research and Development Headquarters, Hokurikit Seiyaku, Co., Ltd.
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TAKAHARA Eiji
Research Division, Hokuriku Seiyaku Co., Ltd.
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YAMADA Takehisa
Research and Development Division, Hokuriku Seiyaku, Co., Ltd.
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Saito T
Research And Development Headquarters Hokurikit Seiyaku Co. Ltd.
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Saito Takako
Research And Development Laboratories Maruho Co. Ltd.
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YAMADA Tatsuhiko
Pharmaceutical Laboratories, Kissei Pharmaceutical Co., Ltd.,
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Suzuki Toshikazu
Discovery Research Laboratory Tanabe Seiyaku Co. Ltd.
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Tsuji Akira
Department Of Molecular Pharmaceutics Graduate School Of Natural Science And Technology Kanazawa Uni
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Yamada T
Department Of Radiopharmacy Tohoku Pharmaceutical University
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Nagata O
Narch
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Takahara E
Research Division Hokuriku Seiyaku Co. Ltd.
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Takahara Eiji
Research Division Hokuriku Seiyaku Co. Ltd.
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Suzuki T
Research Unit Of Pharmaceutics College Of Pharmacy Nihon University
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Yamada Takehisa
Research And Development Division Hokuriku Seiyaku Co. Ltd.
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