Effects of N-[2-(1-Azabicyclo[3,3,0]octan-5-yl)ethyl]2-nitroaniline Fumarate (SK-946), a Novel Cognition Activator, on Learning and Memory in Rodent Models

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概要

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• We examined the effects of N-[2-(1-azabicyclo[3,3,0] octan-5-yl)ethyl]2-nitroaniline fumarate (SK-946) on cognition in various rodent models. SK-946 slightly suppressed spontaneous motor activity, but had no effect on scopolamine-induced motor facilitation. SK-946 ameliorated scopolamine-, pirenzepine-, cycloheximide- and electric shock-induced passive avoidance deficits in rodents when administered before acquiring the training. In an active avoidance test, SK-946 accelerated avoidance acquisition in the later half of training without a marked increase in lever-pressing. In more reliable models of cognitive disorders, i.e. an AF64A intracerebroventricular infusion model using the step-through passive avoidance test, an aged rat model using the step-down passive avoidance test and methylazoxymethanol (MAM)-induced microencephalic rat model using the Morris water maze test, SK-946 ameliorated impaired learning and memory. These results suggest an ability of SK-946 to enhance cognitive functions.

• 公益社団法人日本薬学会の論文
• 1998-07-15

著者

• 斎藤 徹

  Faculty Of Pharmaceutical Sciences Kanazawa University

• Suzuki T

  Drug Discovery Research Laboratory Sanwa Kagaku Kenkyusho Co. Ltd.

• 鈴木 徳治

  千葉大 薬

• Suzuki T

  Laboratory Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Chiba University

• Saito Takako

  Research And Development Laboratories Maruho Co. Ltd.

• Suzuki Toshikazu

  Discovery Research Laboratory Tanabe Seiyaku Co. Ltd.

• Kanda Kazumi

  Pharmaceutical Laboratory Sanwa Kagaku Kenkyusho Co. Ltd.

• Suzuki T

  Research Unit Of Pharmaceutics College Of Pharmacy Nihon University

• SUZUKI Tsunemasa

  Pharmaceutical Laboratory, Sanwa Kagaku Kenkyusho Co., Ltd.,

• HIROOKA Kiyotaka

  Pharmaceutical Laboratory, Sanwa Kagaku Kenkyusho Co., Ltd.,

• HIROOKA Hiroko

  Pharmaceutical Laboratory, Sanwa Kagaku Kenkyusho Co., Ltd.,

• FURUSAWA Kenichi

  Pharmaceutical Laboratory, Sanwa Kagaku Kenkyusho Co., Ltd.,

• Suzuki Tsunemasa

  Pharmaceutical Laboratory Sanwa Kagaku Kenkyusho Co. Ltd.

• Kanda K

  Pharmaceutical Laboratory Sanwa Kagaku Kenkyusho Co. Ltd.

• Furusawa K

  Pharmaceutical Laboratory Sanwa Kagaku Kenkyusho Co. Ltd.

• HIROOKA Kiyotaka

  Central Research Laboratory, Sanwa Kagaku Kenkyusho, Co., Ltd.,

• Hirooka Kiyotaka

  Central Research Laboratory Sanwa Kagaku Kenkyusho Co. Ltd.

• Hirooka Hiroko

  Pharmaceutical Laboratory Sanwa Kagaku Kenkyusho Co. Ltd.

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