Synthesis of (1-Azabicyclo[3.3.0]octanyl)methyl-Substituted Aromatic Heterocycles and Their Muscarinic Activity

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概要

• 論文の詳細を見る

• In our development of srugs effective against Alzheimer's disease, we have researched a series of aromatic compounds having a characteristic cyclic amine, 1-azabicyclo[3.3.0]octane ring.In this report, we descride synthesis of a series of aromatic heterocycles with the 1-azabicyclo[3.3.0]octane ring and their pharmacological evaluation. 3-Amino-5-(1-azabicyclo[3.3.0]octan-5-yl)methyl-1,2,4-oxadiazole(2b) showed the highest M_1 selectivity.

• 社団法人日本薬学会の論文
• 1999-06-15

著者

• 斎藤 徹

  Faculty Of Pharmaceutical Sciences Kanazawa University

• Ikami T

  Miki Corp. Nishinomiya Jpn

• Suzuki T

  Drug Discovery Research Laboratory Sanwa Kagaku Kenkyusho Co. Ltd.

• SUZUKI Tomoo

  Drug Discovery Research Department, Sanwa Kagaku Kenkyusho Co., Ltd.,

• IKAMI Takao

  Drug Discovery Research Department, Sanwa Kagaku Kenkyusho Co., Ltd.,

• HAMAJIMA Hitoshi

  Drug Discovery Research Laboratory, Sanwa Kagaku Kenkyusho Co. Ltd.,

• 鈴木 徳治

  千葉大 薬

• Suzuki T

  Laboratory Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Chiba University

• UESAKA Hiroshi

  Drug Development Laboratory, Sanwa Kagaku Kenkyusho Co., Ltd.,

• Saito T

  Research And Development Headquarters Hokurikit Seiyaku Co. Ltd.

• Saito Takako

  Research And Development Laboratories Maruho Co. Ltd.

• Ikami Takao

  Drug Discovery Research Department Sanwa Kagaku Kenkyusho Co. Ltd.

• Suzuki Toshikazu

  Discovery Research Laboratory Tanabe Seiyaku Co. Ltd.

• Uesaka H

  Drug Development Laboratory Sanwa Kagaku Kenkyusho Co. Ltd.

• Suzuki T

  Research Unit Of Pharmaceutics College Of Pharmacy Nihon University

• Sugihara T

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Saito T

  Research And Development Laboratories Maruho Co. Ltd.

• Hamajima Hitoshi

  Drug Discovery Research Laboratory Sanwa Kagaku Kenkyusho Co. Ltd.

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