Purines. LII. Synthesis and Biological Evaluation of 8-Methylguanine 7-Oxide and Its 9-Arylmethyl Derivatives
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概要
- 論文の詳細を見る
The synthesis of 8-methylguanine 7-oxide (3) was accomplished via a "phenacylamine route", which started from condensation of α-(4-methoxybenzylamino)propiophenone (6), prepared by coupling of α-bromopropiophenone (4) and 4-methoxybenzylamine (5), with 2-amino-6-chloro-5-nitro-4(3H)-pyrimidinone (7) and proceeded through cyclization of the resulting phenacylaminopyrimidinone (8) and removal of the 4-methoxybenzyl group. The N-oxide 3 and its 9-arylmethyl derivatives 9 and 11 showed only very weak antileukemic activity and no antimicrobial activity.
- 社団法人日本薬学会の論文
- 1992-05-25
著者
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斎藤 徹
Faculty Of Pharmaceutical Sciences Kanazawa University
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藤井 澄三
Faculty Of Pharmaceutical Sciences Kanazawa University
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小川 和男
Research Institute, Taiho Pharmaceutical Co., Ltd.
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小川 和男
Faculty Of Pharmaceutical Sciences Kanazawa University
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板谷 泰助
Faculty of Pharmaceutical Sciences, Kanazawa University
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稲垣 甚一郎
Research Laboratories, Ikeda Mohando Co., Ltd.,
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野原 富士夫
Research Laboratories, Ikeda Mohando Co., Ltd.,
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西井 正廣
Research Laboratories, Ikeda Mohando Co., Ltd.,
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板谷 泰助
金沢大学薬学部
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Saito T
Research And Development Headquarters Hokurikit Seiyaku Co. Ltd.
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稲垣 甚一郎
Research Laboratories Ikeda Mohando Co. Ltd.
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Ogawa K
Showa Pharmaceutical University
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Inagaki J
Graduate School Of Pharmaceutical Sciences Hokkaido University
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Nohara F
Research Laboratories Ikeda Mohando Co. Ltd.
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野原 富士夫
Research Laboratories Ikeda Mohando Co. Ltd.
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西井 正廣
Research Laboratories Ikeda Mohando Co. Ltd.
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藤井 澄三
Shinshu Univ. Nagano Jpn
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