Lactams. XX. Decarboxylation of Unsaturated Acids incorporated into Six-Membered Lactam Systems

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概要

• 論文の詳細を見る

• The thermal decarboxylation of some unsaturated acids (1,5,6,8,and 9) incorporated into six-membered lactams was examined. Although 8 and 9 did not undergo decarboxylation when heated neat at 175-180℃ and 240-245℃, respectively, for 2 h, 1,5,and 6 were decarboxylated in 1,1,2,2-tetrachloroethane at 135℃. The relative ease of the reaction was in the order of 1≥6≫5. In the case of 1,the rate-decreasing effects observed on dilution and on the addition of trichloroacetic acid suggest the reaction to be a dimeric intermolecular process.

• 公益社団法人日本薬学会の論文
• 1981-11-25

著者

• 藤井 澄三

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 大場 正志

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 植田 祐子

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 大場 正志

  Kanazawa Univ. Ishikawa Jpn

• 古源 寛

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 古源 寛

  Faculty Of Pharmaceutical Sciences Kanazawa University

• Ohba M

  Faculty Of Pharmaceutical Sciences Kanazawa University

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